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Bangladesh: first human case of H5N1 bird flu - 2008

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  • #31
    Re: Bangladesh: first human case of H5N1 bird flu

    Source: http://www.ipsnews.net/news.asp?idnews=42493

    BANGLADESH: Human Bird Flu Case Deadly for Poultry Industry
    By Farid Ahmed

    DHAKA, May 24 (IPS) - Authorities here have stepped up surveillance against avian influenza after the case of a 16-month-old boy, who took ill in January, was diagnosed as one of infection with the deadly H5N1 virus.

    Bangladesh become the 15th country to report a case of human infection after the Geneva-based World Health Organisation (WHO), citing results from laboratories at the Centres for Disease Control (CDC) in Atlanta, confirmed the infection on Thursday.

    Since 2003, when bird flu first surfaced, 15 countries have reported a total of 382 human cases, with 241 of them turning fatal. WHO has now confirmed human cases in Azerbaijan, Cambodia, China, Djibouti, Egypt, Indonesia, Iraq, Laos, Burma, Nigeria, Pakistan, Thailand, Turkey, Vietnam and Bangladesh.

    Prof. Mahmudur Rahman, a director at Bangladesh?s Institute of Epidemiology, Disease Control and Research (IEDCR), told IPS that although the boy was totally cured well before the confirmation, surveillance has been stepped up across the country.

    Since the H5N1 virus was first detected in Bangladesh, at a state-run poultry farm on the outskirts of the capital, authorities have culled more than two million birds, causing losses estimated at 700 million US dollars.

    With 47 of Bangladesh?s 64 districts affected, the poultry industry, introduced two decades ago to help this impoverished country, is now facing its biggest ever challenge. Affected are more than 1.5 million people employed in one of the world's largest poultry industries that produces producing 220 million chickens and 37 million ducks annually.


    According to the South Asia Enterprise Development Facility, a multi-donor facility managed by the International Finance Corporation of the World Bank Group, the poultry sector supports five million people directly or indirectly through 150,000 poultry farms, constituting 1.6 percent of Bangladesh's gross domestic product (GDP).

    In recent years, the poultry industry has been growing at an annual rate of about 20 percent, recording a turnover of 25 -1.5 billion dollars in 2006. Analysts say the figures for 2007 may fall below that mark thanks to drastic culling.


    Battered by the culling, monsoon floods and a devastating cyclone in November, the country's once booming poultry industry is now seriously threatened. Businessmen say the outbreak has already caused the closure of more than a third of the country?s poultry farms.

    As the virus spread, the state-owned Bangladesh TV and a dozen or so private cable TV channels often broadcast programmes on avian influenza making people aware of the deadly virus, but observers said impact is minimal.

    ??Street vendors are still selling live chickens in Dhaka, although the city corporation authority has imposed a ban on selling live chickens in the open,?? said Dhaka school teacher Sharif Ahmed.

    Without disclosing the identity of the affected boy, Rahman said he lived in a crowded slum in Dhaka. His parents had bought a live chicken from a nearby market which they kept in their house for some days before slaughtering it for a meal.

    The boy was among the more than 3,000 people suspected of being infected with bird flu in Bangladesh, but his was the only case that tested positive, a health department official said.

    After the Bangladesh government was informed of the test results by the WHO, the national advisory committee on avian influenza met on Thursday to step up measures.

    Rahman said IEDCR was already conducting surveillance measures in the districts affected by bird flu and that people who were in direct contact with poultry birds and products were being kept under observation by epidemiologists. As part of the new measures, Bangladesh will set up isolation units in all public hospitals, he said.

    "Right now everything is under control.
    We have trained doctors and readied hospitals to tackle any new detection," Rahman said. ??We also have trained volunteers in the villages.??

    Bangladesh, which has a population of nearly 150 million, is the world's most densely populated country with nearly 1,000 people per sq km. With poultry farms set up everywhere in the country the risk of the virus spreading fast is high.

    Earlier this year, India?s West Bengal state which shares a long border with Bangladesh suffered the neighbouring country?s worst outbreak of the virus among poultry. But no human cases of bird flu have been reported in India, which has also carried out massive poultry culling.

    Bird flu was thought only to infect birds until the first human cases were detected in Hong Kong in 1997. Though rare, humans catch the disease through close contact with infected birds.

    Experts consider vigilance and speedy action such as isolation of human cases important because of a fear that the H5N1 strain could mutate to become capable of human-to-human transmission and set off a deadly pandemic. Densely populated countries like Bangladesh, where people live in close proximity to backyard poultry or keep birds in their homes, are seen as particularly risky.

    (END/2008)

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    • #32
      Re: Bangladesh: first human case of H5N1 bird flu


      Govt gears up bird flu preparedness

      Alpha Arzu

      The government plans to introduce isolation units at 33 district level public hospitals to treat patients infected with avian influenza by June, as the viral infection has already been detected in a child in Dhaka.

      Besides establishing the 33 units with at least four beds each, the government will also start surveillance at 18 more district hospitals with the existing 12 where surveillance started amid the first outbreak of bird flu in March 2007, said Mahmudur Rahman, director of the Institute of Epidemiology, Disease Control and Research.

      The initiatives were taken before detection of the first case of bird flue infection in human body on Wednesday, said director of disease control of the directorate general of health services, Moazzem Hossain. ?Now all the steps will be swift.?

      As part of the preparedness of tackling human infection of H5N1, the government has also stocked up a large number of anti-viral drug and protective equipments, said Mahmudur Rahman.

      The government has already established an 8-bed avian influenza ward at the chest diseases instate and hospital in Mohakhali with artificial ventilation system, and all drugs and facilities to treat such patients.

      To diagnose the infection, the government has established a laboratory with real-time polymerase chain reaction, a rapid method for diagnosis of all kinds of influenza viruses, on the second floor of the IEDCR building at Mohakhali and invited international tenders for procurement of machinery for the laboratory, said an official of the IEDCR.

      Mahmud told New Age on Saturday, ?The PCR is a method for amplifying a small amount of deoxyribonucleic acid or ribonucleic acid into large quantities in a few hours. Real-time PCR lets a scientist view the increase in DNA as it is amplified, and allows rapid screening of samples for diagnosis and disease tracking.?

      The government also ordered installing a Bio Safety Level 3 Laboratory on the IEDCR premises to tackle incidence of influenza and other dangerous pathogens within four to five months. The BSL 3 Lab will be brought in from the Hong Kong.

      With the assistance of international financial institutions and lending agencies, the government has already trained a large number of health professionals and people.

      There are 12-member teams in districts and four-member teams at the upazila level for rapid response that have been working around the country.

      Besides there are about 2,26,100 volunteers at the union that working to raise the awareness of the people. They are visiting the door to door with messages and leaflets, said health officials.

      The first bird flu in human body was detected on May 21. The Centre for Disease Control and Prevention, USA, diagnosed a 16-month-old Bangladeshi child as being infected with H5N1, the virus that causes avian influenza.

      The country?s first bird flu case was detected in March 2007 in poultry. About 287 farms with confirmed H5N1 virus cases were reported in 47 districts till May 21 in 2008, according to the Ministry of Fisheries and Livestock.

      The government has so far exterminated more than 16,37,266 fowl and destroyed about 22 lakh eggs in 505 commercial and 42 backyard farms in the country.

      The symptoms are similar to other types of flu ? fever, malaise, sore throat and coughing. Humans can also develop conjunctivitis because of the virus.

      The World Health Organization confirmed 382 cases of H5N1 in humans in Azerbaijan, Cambodia, China, Djibouti, Egypt, Indonesia, Iraq, Laos, Myanmar, Nigeria, Pakistan, Thailand, Turkey and Vietnam, leading to 241 deaths, between 2003 and April 30, 2008.

      http://www.newagebd.com/front.html#16
      credits Ter
      ?Addressing chronic disease is an issue of human rights ? that must be our call to arms"
      Richard Horton, Editor-in-Chief The Lancet

      ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~

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      • #33
        Re: Bangladesh: first human case of H5N1 bird flu

        Young boy in Bangladesh recovers from bird flu-WHO
        28 May 2008 15:54:27 GMT
        <!-- 28 May 2008 15:54:27 GMT ## for search indexer, do not remove -->Source: Reuters

        <!-- AN5.0 article title end --><SCRIPT language=JavaScript src="/bin/js/article.js"></SCRIPT></SPAN><INPUT id=CurrentSize type=hidden value=13 name=CurrentSize> <!-- Young boy in Bangladesh recovers from bird flu-WHO --><!-- Reuters -->GENEVA, May 28 (Reuters) - An infant in Bangladesh contracted H5N1 bird flu and survived, in the South Asian country's first human infection with the virus, the World Health Organisation (WHO) said on Wednesday.
        In a statement released in Geneva, the United Nations agency said a 16 month-old boy from Komalapur, Dhaka, developed symptoms in late January and then recovered.
        "The case was exposed to live and slaughtered chickens at his home," the WHO said. "Specimens have been collected from his family members and neighbours. All remain healthy to date."
        The H5N1 virus has infected millions of birds in much of Asia, Africa, and some parts of Europe. Public health experts fear it could spark a human pandemic if it mutates into a form that passes easily between people.
        A total of 383 humans are known to have been infected with the virus since 2003, and 241 have died, according to the WHO.
        The Bangladeshi infection was flagged during surveillance activities by the International Centre for Diarrhoeal Disease Research Bangladesh, the WHO said. (Reporting by Laura MacInnis; Editing by Elizabeth Piper)

        The intelligence, technology, and human expertise you need to find trusted answers.

        <!-- news ## for search indexer, do not remove -->

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        • #34
          Re: Bangladesh: first human case of H5N1 bird flu

          28 May 2008 -- </SPAN>The Ministry of Health, Bangladesh has confirmed its first case of human infection with H5N1 avian influenza. The case was identified retrospectively as part of seasonal surveillance activities run by the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDRB).
          The case is a 16-month-old male from Komalapur, Dhaka. He developed symptoms on 27th January 2008 and subsequently recovered. The case was confirmed as being infected with A(H5N1) by the WHO H5 Reference Laboratory, US Centers for Disease Control and Prevention (CDC). The case was exposed to live and slaughtered chickens at his home. Specimens have been collected from his family members and neighbours. All remain healthy to date.

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          • #35
            Re: Bangladesh: first human case of H5N1 bird flu

            [From WHO SEARO Website - IOH]

            29 May 2008 ? Bangladesh

            Outbreaks of Avian Influenza in Indonesia, India, Myanmar and Thailand have been reported among poultry.

            Human cases of Avian Influenza have been reported from Bangladesh, Indonesia, Myanmar and Thailand.

            Thailand has reported 25 cases with 17 deaths since December 2003.
            The last human case in Thailand was reported in September, 2006.

            WHO has reported 133 laboratory confirmed human cases of avian influenza in Indonesia, with 108 deaths since July 2005.

            Bangladesh has confirmed its first case of human infection with H5N1 avian influenza, the case is a 16-month-old male from Komalapur, Dhaka.

            The case is a 16-month-old male from Komalapur, Dhaka. He developed symptoms on 27th January 2008 and subsequently recovered.
            The case was confirmed as being infected with A(H5N1) by the WHO H5 Reference Laboratory, US Centers for Disease Control and Prevention (CDC). The case was exposed to live and slaughtered chickens at his home. Specimens have been collected from his family members and neighbours. All remain healthy to date.

            As of 28 May 2008, the Ministry of Fisheries and Livestock, Government of Bangladesh, reported that culling of poultry has taken place in 547 farms, spread over 47 districts.
            1. Dhaka,
            2. Gazipur,
            3. Narayangonj,
            4. Tangail,
            5. Jamalpur,
            6. Jessore,
            7. Noakhali,
            8. Gaibandha,
            9. Magura,
            10. Rajbari,
            11. Nilfamari,
            12. Dinajpur,
            13. Rangpur,
            14. Joypurhat,
            15. Lalmonirhat,
            16. Thakurgaon,
            17. Naogaon,
            18. Bogra,
            19. Feni,
            20. Pabna,
            21. Kurigram,
            22. Moulvibaza,
            23. Barisal,
            24. Barguna,
            25. Rajshahi,
            26. Natore,
            27. Patuakhali,
            28. Netrokona,
            29. Bhola,
            30. Kulna,
            31. Manikgonj,
            32. Gopalgonj,
            33. Mymensingh,
            34. Sylhet,
            35. Kustia,
            36. Jhinaidah,
            37. Norsingdhi,
            38. Bagerhat,
            39. Chittagong,
            40. Kishoreganj,
            41. Meherpur,
            42. Comilla,
            43. Shariatpur,
            44. Munshiganj
            45. Chandpur,
            46. Satkhira and
            47. B Baria.

            A total of 1,637,266 chickens have been culled.
            -
            World Health Organization South-East Asia provides leadership on health matters, articulates evidence-based policy options, provides technical support to countries and monitors health trends. World Health Organization South-East Asia is working with Bangladesh, Bhutan, Democratic People’s Republic of Korea, India, ​Indonesia, ​Maldives, ​​Myanmar, Nepal, ​​Sri Lanka, ​​Thailand, Timor-Leste to address persisting and emerging epidemiological and demographic challenges.

            ------

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            • #36
              Re: Bangladesh: first human case of H5N1 bird flu

              First human infection with Influenza A H5N1 confirmed in Bangladesh

              The first human case of influenza A H5N1 recognized in Bangladesh and was notified to WHO by Bangladesh Government on 22 May, 2008. The case occurred in a 15 month old child from Dhaka. He developed fever and difficulty breathing, but recovered completely. His likely exposure was to a chicken that was slaughtered in his household. Physicians who see patients with serious respiratory illness should take a history of exposure to sick poultry and contact IEDCR if they suspect highly pathogenic avian influenza.
              We report the first case of human infection with influenza A, H5N1 confirmed in Bangladesh. The case was identified as part of the population based surveillance in urban Dhaka. Upon laboratory confirmation of the case an investigation team re-evaluated the affected child and family and investigated potential sources for the infection.
              The World Health Organization and the Food and Agriculture Organization monitor strains of influenza circulating globally to identify dangerous emerging strains with the hope that early recognition and intervention a high mortality pandemic can be avoided. Strains of Influenza A, H5N1, first identified in Hong Kong in 1997 have been circulating in Asia since 2001. These strains have caused high mortality outbreaks among poultry throughout Asia, and in many countries in Europe and Africa. The H5N1 virus is a adapted to birds, the natural host of influenza viruses. However, these strains occasionally infect humans. Among the 383 human cases of H5N1 recognized and reported to the World Health Organization by 28 May 2008, 241 (63%) had died. If the H5N1 virus develops the capacity to efficiently transmit from person to person, this could cause a deadly pandemic.
              The government of Bangladesh confirmed the presence of influenza A, H5N1 virus in poultry in March 2007 and since then poultry outbreaks of H5N1 have been confirmed in 47 of the 64 districts in Bangladesh. ICDDR,B collaborates with the Government of Bangladesh on human surveillance for influenza under two broad activities, national hospital surveillance in 12 hospitals across the country and population based surveillance in a low income community in urban Dhaka.

              Kamalapur is a densely populated, low-income community in Dhaka city. Since March 2004, approximately 5000 households with children under the age of 5 years are under active surveillance for respiratory illness. Each week a field worker visited participating households and referred children to the clinic who had signs of serious respiratory illness. Participating families were encouraged to bring their children to the clinic if they developed signs or symptoms of illness on days that the field worker did not come to visit them in the home. In the clinic physicians performed a standardized exam, and ordered additional studies based on specific findings. Every fifth child from the surveillance area who met the criteria for acute infectious respiratory illness had a nasopharyngeal wash specimen collected. An aliquot of the nasopharyngeal washes was placed on tissue culture in the Virology Laboratory of ICDDR,B, and incubated. If cytopathic effect was noted, the tissue culture supernatant was collected and a haemagglutination inhibition test conducted using the standard WHO influenza reagent kits for Influenza A (H1N1), Influenza A (H3N2), Influenza B Shanghai and Influenza B/Hong Kong.

              A 15 month old Kamalapur resident developed cough and runny nose on 22 January 2008. By 27 January his breathing was labored. On 29 January his mother brought him to the ICDDR,B clinic in Kamalapur. On examination the child had a temperature of 38.1 ?C, a respiratory rate of 40 breaths per minute, pulse of 124, weight for age was the 78th percentile and there were no abnormal sounds on chest auscultation. Because the child was part of the active surveillance system, a chest radiograph was obtained. The child was also selected as one of the one in every 5 children selected for nasopharyngeal wash and influenza culture.

              The initial clinical impression was enteric fever. The child was treated with amoxicillin. The chest radiograph was later interpreted as showing an alveolar infiltrate. Because the child was in the surveillance system, a field worker visited him daily at his home. He was also seen in the clinic for follow-up on 31 January, 5 February, 10 February and 13 February. Although the mother reported the child had fever at home as late as 7 February, an elevated temperature was not identified after the initial clinic visit. The child completed a 13 day course of amoxicillin. On his last clinic visit on 13 February the child was clinically well. The final clinical diagnosis was upper respiratory tract infection. The child was re-evaluated on 22 May and remained clinically well.

              The culture of the child?s nasopharyngeal wash specimen showed cytopathic effect typical of influenza virus, reacted against antibody to influenza A, but the specimen did not agglutinate with H1 or H3 antisera. The specimen was forwarded to the Centers for Disease Control in Atlanta, Georgia for further characterization. At the Centers for Disease Control the isolate was confirmed as a highly pathogenic Influenza A, H5N1, by anti-sera agglutination and real time PCR. The viral genome was sequenced. It was a clade 2.2 virus.

              The infected child lived with his mother, sister, and father in a one room residence in the Kamalapur community. The child?s father bought a live broiler chicken from a poultry shop located 50 meters from the residence at 11:00 am at some time in January. He kept the chicken near the door of their one room house where the affected child was sleeping. At 12:00 pm, the child?s mother with the help of her next door neighbor slaughtered the chicken inside the bathroom near the tap. While they were slaughtering the chicken, the child was sleeping and immediately after the processing of the chicken, the child awoke. Neither the mother nor the neighbor washed their hands. The mother handed the child to the neighbor. The mother gathered all the entrails, organs and other wastes of the chicken in a polythene bag, tied a knot in that bag and kept it near the main entrance of the house. The waste bag remained there for about two hours.

              The poultry shop where the father bought the chicken sold an average of 15 chickens per day. The owner purchased chickens from the Jatrabari whole sale market in Dhaka. One day during the first three weeks in January he recalled that three of the chickens that he purchased died on the same day. This was quite an unusual event. Poultry wholesalers at the Jatrabari whole sale poultry market report purchasing their poultry mostly from Savar, Gazipur, Norshingdi, Munshigonj, Brahmanbaria, and Commilla outside Dhaka. During January they recalled that deaths among poultry in cages occurred commonly averaging among 5 ? 10% of chickens each day. Fifty outbreaks of H5N1 were confirmed in Bangladesh in January.

              The mother also reported that the child ate a soft boiled egg each day in January. None of the child?s family members reported illness during the time that the index child was ill nor in the following two weeks.

              Reported by:
              Institute for Epidemiology Disease Control and Research (IEDCR), Ministry of Health and Family Welfare, Government of the People?s Republic of Bangladesh


              IEDCR is the national institute for conducting disease surveillance and outbreak investigation. It has been engaged in controlling disease and involved in researches on health events of public health importance.
              Twitter: @RonanKelly13
              The views expressed are mine alone and do not represent the views of my employer or any other person or organization.

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