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Bangladesh - team to look into 'paracetamol' deaths of 24 children

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  • Bangladesh - team to look into 'paracetamol' deaths of 24 children

    JS team to look into 'paracetamol' deaths of 24 children

    Thu, Jul 23rd, 2009 3:44 pm BdST

    Dhaka, July 23 (bdnews24.com) ? A four-member parliamentary team was formed Thursday to look into the recent deaths of 24 children from kidney failure after reportedly taking a children's paracetamol product.

    The Drug Administration has asked the Rid Pharmaceutical Company to stop production of a paracetamol suspension reportedly containing toxic ingredients.

    The parliamentary standing committee on the health ministry formed the team, headed by MP Nazmul Hasan, which will to visit pharmaceutical factories across the country, committee chairman Sheikh Fazlul Karim Selim told reporters.

    Hassan is himself a managing director of a drugs company, Beximco Pharmaceuticals, and also an adviser to the Bangladesh Association of Pharmaceutical Industries.

    There will be three experts on the committee, who will examine the production facilities of the factories and submit a report in three months, Karim said.

    The standing committee also recommended the government build a modern laboratory to test pharmaceutical products. There are now two laboratories in Dhaka and Chittagong but they lack modern technology.

    Health minister Ruhal Haque attended the meeting.

    Children's deaths

    Dhaka Shishu (Children's) Hospital has seen 19 deaths due to renal failure in the last one and a half months, according to newspaper reports.

    The hospital authorities have said that a total of 26 child patients with renal failure have been admitted to the hospital since the start of June. The unusually high figure reportedly led one doctor to test a suspicious drug product at a private laboratory.

    Five renal failure deaths at BSMMU Hospital have also forced it to form a three-member committee to investigate the issue.

    The Drug Administration on Wednesday ordered the Rid Pharmaceutical Company in Brahmanbaria to suspend manufacture and marketing of their products including vitamin and paracetamol suspensions for children, and to publish an announcement in three daily newspapers.

    Drug Administration officials also visited the factory site and took samples for testing.

    The government has also said a separate seven-member investigation body, formed earlier in the week, has already started collecting samples of Rid's vitamin and paracetamol suspensions from different areas of the country.

    If nothing harmful is found in the products, the company could resume production again, said officials.

    bdnews24.com/krc/su/bd/rah/1536h.

    Bangladesh's largest news publisher by reach - 24/7, bilingual; content opened to public on 23 Oct 2006

  • #2
    Re: Bangladesh - team to look into 'paracetamol' deaths of 24 children

    Dhaka, Jul 26 (bdnews24.com)?A Dhaka University professor has said the toxic chemical compounds, suspected of causing the deaths of at least 25 children in the past month and a half, have a history of use by unscrupulous drug manufacturers in the country.

    "In 1992, many children died when diethylene glycol was mixed with a paracetamol product," Prof Abu Sara Shamsur Rouf, of Dhaka University's pharmaceutical technology department, told bdnews24.com on Sunday.

    He said pharmaceutical factories are known to use ethylene glycol and diethylene glycol as a solvent in certain paracetamol preparations, instead of the approved propylene glycol.

    "These chemicals are cheaper, and smaller amounts of them are required to perform the same task," said Rouf.

    He said at least three times more propylene glycol is required to dissolve paracetamol in water than ethylene glycol or diethylene glycol.

    Rouf also said unscrupulous chemical vendors could adulterate propylene glycol with the more toxic compounds to increase their profit margins.

    "But it is possible for drug manufacturers to determine whether propylene glycol has been adulterated prior to the manufacturing process."

    Rouf said an overdose of the approved propylene glycol can also damage the kidneys, liver and brain.

    The US Food and Drug Administration approves the use of no more than 0.1 percent of propylene glycol in the preparation of medicines, he said.

    Health minister AFM Ruhal Haque, speaking at a press briefing earlier in the day, said diagnostic tests were being carried out by a laboratory on samples taken from a number of children who suffered the suspected poisoning.

    Tests were also being done on samples of a children's paracetamol suspension manufactured by the Rid Pharamaceutical Company, which is suspected of adulteration, he said.

    Haque said he would not confirm the nature of the children's illnesses or comment on the cause until the results had come in.

    He also said a top-level ministerial committee had now been formed to investigate the children's deaths, in addition to a four-member parliamentary team formed on July 23.

    Prof Golam Mainuddin, a paediatric nephrology lecturer at Bangabandhu Sheikh Mujib Medical University and a member of the probe committee, said haemodialysis is required in cases of kidney failure due to glycol intoxication.

    bdnews24.com/mrf/khk/h/am/2359h

    Bangladesh's largest news publisher by reach - 24/7, bilingual; content opened to public on 23 Oct 2006

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