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Belgium - More patients and hospitals with antibiotic resistant bacteria ( CPE, incl. MCR-1 Colistin-resistant) - "Establishment of CPE in the community" - Eurosurveillance

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  • Belgium - More patients and hospitals with antibiotic resistant bacteria ( CPE, incl. MCR-1 Colistin-resistant) - "Establishment of CPE in the community" - Eurosurveillance

    Eurosurveillance, Volume 22, Issue 19, 11 May 2017
    Surveillance and outbreak report

    INCREASING PROPORTION OF CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE AND EMERGENCE OF A MCR-1 PRODUCER THROUGH A MULTICENTRIC STUDY AMONG HOSPITAL-BASED AND PRIVATE LABORATORIES IN BELGIUM FROM SEPTEMBER TO NOVEMBER 2015

    Carbapenemase-producing Enterobacteriaceae (CPE) strains have been increasingly reported in Belgium. We aimed to determine the proportion of CPE among Enterobacteriaceae isolated from hospitalised patients and community outpatients in Belgium in 2015.

    For the hospitalised patients, the results were compared to a previous similar survey performed in the same hospitals in 2012. Twenty-four hospital-based and 10 private laboratories collected prospectively 200 non-duplicated
    Enterobacteriaceae isolates from clinical specimens. All isolates were screened locally by carbapenem disk diffusion using European Committee on Antimicrobial Susceptibility Testing methodology. Putative CPE strains with inhibition zone diameters below the screening breakpoints were referred centrally for confirmation of carbapenemase production.

    From September to November 2015, we found a proportion of clinical CPE of 0.55% (26/4,705) and of 0.60% (12/1,991) among hospitalised patients and among ambulatory outpatients respectively.
    Klebsiella pneumoniae (26/38) and OXA-48-like carbapenemase (28/38) were the predominant species and enzyme among CPE. One OXA-48-producing Escherichia coli isolated from a hospital was found carrying plasmid-mediated MCR-1 colistin resistance.

    Compared with the 2012 survey, we found a significant increased proportion of clinical CPE (0.55% in 2015 vs 0.25% in 2012; p = 0.02) and an increased proportion of hospitals (13/24 in 2015 vs 8/24 in 2012) with at least one CPE detected.

    The study results confirmed the concerning spread of CPE including a colistin-resistant MCR-1 producer in hospitals and the establishment of CPE in the community in Belgium.



    LINK TO FULL ARTICLE





    “Addressing chronic disease is an issue of human rights – that must be our call to arms"
    Richard Horton, Editor-in-Chief The Lancet

    ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~
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