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The Mold Rush: While many warn of an antibiotic apocalypse, Los Alamos structural biologist Alex Koglin remains hopeful

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  • The Mold Rush: While many warn of an antibiotic apocalypse, Los Alamos structural biologist Alex Koglin remains hopeful


    WE WERE WARNED. The rise of antibiotic resistance is not a surprise.
    In 1945, when Sir Alexander Fleming accepted the Nobel Prize for his discovery
    of penicillin, he suggested that society should be careful with antibiotics and
    that misuse would lead to resistant organisms. He was right, and throughout the
    last 70 years, he was not the only one to sound an alarm.
    Society is now on the brink of losing the ability to fight dangerous
    infections. Bacteria have gained resistance to our arsenal of antibiotics and have
    shared their strategies with each other. The once-revered miracle drug penicillin
    that revolutionized medicine?a compound made by blue-green mold with the
    express purpose of fighting off its enemy bacteria?is now rarely used, and most
    of its derivatives are dropping out of commission one by one.
    However, while negligent use may fuel resistance, the problem is intensified
    by the fact that very few new antibiotics have been approved in the last
    few decades. The high cost of research and clinical trials, coupled with the fact
    that resistance is a natural phenomenon that will inevitably render new drugs
    useless after some period of time, makes their development less profitable. In
    fact, many pharmaceutical companies have not researched new antibiotics since
    the 1990s.
    While many warn of an antibiotic apocalypse, Los Alamos structural
    biologist Alex Koglin remains hopeful. His passion for understanding the
    structures of proteins and enzymes has led him to a novel approach for
    identifying new therapeutics. But that?s not all. Using this technique, he and his
    team mined the genomes of thousands of organisms, and earlier this year they
    discovered two completely new antibiotics.
    Miracle mold...
    _____________________________________________

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    "...there’s an obvious contest that’s happening between different sectors of the colonial ruling class in this country. And they would, if they could, lump us into their beef, their struggle." ---- Omali Yeshitela, African People’s Socialist Party

    (My posts are not intended as advice or professional assessments of any kind.)
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