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80% Of Adult Cattle Still Protected Against Schmallenbergvirus After 24 Months

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  • 80% Of Adult Cattle Still Protected Against Schmallenbergvirus After 24 Months

    Schmallenberg virus antibody persistence in adult cattle after natural infection and decay of maternal antibodies in calves

    BMC Veterinary Research 2014, 10:103 doi:10.1186/1746-6148-10-103

    Published: 1 May 2014


    Abstract (provisional)

    Background
    Schmallenberg virus (SBV) has swept through the major part of Europe in the period 2011-2013. A vaccine against SBV has been developed and may be a possible preventive instrument against infection. Presently, there is no data available to refute the assumption that natural SBV infection results in long-term immunity. In that respect, it is of interest to know how long (protecting) virus-neutralizing antibodies are present in naturally infected animals. New-born calves acquire passive immunity from their dams by ingestion and absorption of antibodies present in colostrum, which can block the production of serum antibodies when vaccine is administered to calves with maternally derived antibodies. In that respect, it is useful to know how long it takes for maternal antibodies against SBV to disappear in young animals born from infected dams.

    Results
    Longitudinal whole-herd serological monitoring using virus neutralization test (VNT) indicated that 80% of adult dairy cows still had measurable antibodies against SBV at least 24 months after the estimated introduction of the virus into the herd. Median 2 Log VNT titer of the adult dairy cows (>=1 year) dropped from 8.6 to 5.6 in a period of 17 months. Median 2 Log VNT maternal antibodies titers of calves sampled within 30 days after birth was 8. Calves lost their maternally-derived antibodies after 5-6 months. There was a definite positive relationship between the VNT titer of the dam and the VNT titer of the corresponding calf (age <= 30 days) of dam-calf combinations sampled on the same day: the higher the VNT titer of the dam, the higher the VNT titer (maternal antibodies) of the calf.

    Conclusions
    Our field data support the assumption that natural SBV infection in adult cows results in persistence of specific antibodies for at least two years. Based on the observed decay of maternally-derived antibodies in calves, it is presumed safe to vaccinate calves against SBV at an age of approximately 6 months.

    Full PDF document
    “Addressing chronic disease is an issue of human rights – that must be our call to arms"
    Richard Horton, Editor-in-Chief The Lancet

    ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~
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