Discover new swine flu virus

[Tonka]

Not much info on this....

http://www.elpais.com.uy/130108/ultmo-687124/ultimo-momento/descubren-nuevo-virus-de-gripe-porcina/

Spanish-English translation

Discover new swine flu virus
Tags: - flu - Health - researchers - swine - UNAM

A new swine flu virus that can jump the species barrier and infect humans was found by researchers at the National Autonomous University of Mexico (UNAM).

By isolation techniques and molecular biology, researchers at the Faculty of Veterinary Medicine of Mexico pigs sampled from various parts of the country to isolate virus and potential pathogenic mutations or recombinations with different species as man.

Iván Sánchez, head of the Department of Medicine and Animal Science faculty Pig reported new swine viruses were isolated that potentially can affect humans. The researchers will conduct studies to know them better and see what are the real possibilities of risk to humans.

OTHER CASES. Since 2009 virus have been found in pigs with human flu genes and other birds from the United States.

Experts say that even some migratory birds such as herons and ducks come from Canada and the U.S. and Mexican lagoon reach areas, carry most of the "subtypes" of viruses found.

Currently circulating in pigs three subtypes of influenza virus (flu): HIN1, H3N2 and recombination of both: H1N2.

[Tonka]

Re: Discover new swine flu virus

http://www.eluniversal.com.mx/primera/41172.html

Spanish-English translation

Discovery of a new influenza virus
Found in pigs, the strain was isolated by researchers at UNAM.
IPN develops antiviral against A/H1N1



VACCINE. Researchers at the National School of Biological Sciences, National Polytechnic Institute developed an antiviral against human influenza viruses. The patent is already pending. (Photo: UNIVERSAL ARCHIVE)

Tuesday January 8, 2013
Nurit Carballo Martinez | The Universal

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nurit.martinez @ eluniversal.com.mx

While at the National Autonomous University of Mexico (UNAM) announced the isolation and monitoring of a new influenza virus in pigs that may infect humans, the National Polytechnic Institute (IPN) was developed against the virus antiviral human influenza, three years caused alarm in Mexico for his appearance.

The researcher Blanca Lilia Romero Barron, National School of Biological Sciences (ENCB), Thomas Drive, explained that the antiviral is based on the identification of important regions in the viral protein hemagglutinin (HA) antigenic glycoprotein found in the surface of the influenza virus and responsible for binding the virus to the infected cell, which is essential for the initiation of viral infection.
In the laboratory of Virology ENCB analyzed 16 different types of viral hemagglutinin, highly conserved regions were sought between different types of this protein with similar physicochemical properties, which were obtained from several small peptides (less of 20 amino acids) that could block the function of the original protein, because they compete against it as recognition sites, the researcher explained polytechnic.

Romero Barron reported that currently there are two groups of said virus antiviral, one of these is amantadine and its derivatives, which prevent successfully enter into the cell, although in recent years it has been found that most strains of global influenza are resistant to the antiviral group, as such was not used in the pandemic of three years ago.
Noted that the other group of antiviral are oseltamivir and zanamivir, which act by inhibiting a viral enzyme that is important for outputting new viruses such as the neuraminidase (NA), an enzyme present in the envelope of the virus capsid flu.
The report on the results and peptide sequences were submitted to the Institute of Science and Technology of the Federal District (ICyTDF), which granted funding for the project in 2009 after the pandemic, in order to shape the antiviral. The research is ready and pending patent application.
"So far there is only one type of antiviral useful in combating infections caused by influenza A virus, and are the neuraminidase inhibitors, for this reason my work has focused on the production of new options to fight elsewhere virus and thus, through combination therapies against different viral targets, reducing the generation of drug-resistant strains, "he explained.

Research of the UNAM

Meanwhile, in the UNAM Jos? Iv?n S?nchez Betancourt, head of the Department of Medicine and Animal Science, Faculty of Pigs Veterinary Medicine (FMVZ) reported that was isolated, and are monitored and also, new influenza viruses in these animals, which potentially could infect humans.

With samples from different Mexican states, like Queretaro, Guanajuato, Michoac?n, Jalisco, Mexico State, Oaxaca, Chiapas, Puebla, Veracruz, Tlaxcala, Morelos and the Federal District, was identified by viral isolation techniques and molecular biology, the existence of a virus in circulation and detect mutations in these, or recombination between the different subtypes reported in other species.
From 2009 to date, virus found in pigs, which have certain genes of human influenza, and some that come from birds, which was detected as in other countries, such as America.
One of the main problems is that migratory waterfowl, such as ducks and herons ranging from Canada to the American Union, and become Mexican lagoons are the main carriers of most subtypes reported.

[Tonka]

Re: Discover new swine flu virus

http://www.proceso.com.mx/?p=329767

Spanish-English translation

Virus detected in pigs one thousand 200 potential transmission to humans
DRAFTING
JANUARY 7, 2013 ? 3 COMMENTS
NATIONAL
MEXICO, DF (Ap). - New virus mutations detected in pigs-a thousand 200 -, capable of infecting humans, such as H1N1, have been discovered in different states by researchers at the Faculty of Medicine, Veterinary and Husbandry (FMVZ) of the UNAM.

According to studies, so far only these viruses are among the pig population, but if they mutated with other subtypes have the capacity to infect humans.

And worse: antivirals available, such as those used in the 2009 pandemic, would not work for tolerance to drugs, warns Jos? Iv?n S?nchez Betancourt, head of the Department of Medicine and Animal Science of the FMVZ Pigs.

According to the scholar, since 2009 when it registered the pandemic H1N1 virus, to date, they have collected 200 thousand samples to identify new pathogens with potential for transmission to other species.

He explained that the Department of Medicine and Animal Science of the FMVZ Pigs, obtained samples of Quer?taro, Guanajuato, Michoac?n, Jalisco, Mexico State, Oaxaca, Chiapas, Puebla, Veracruz, Tlaxcala, Morelos and the Federal District, among others, to identify for viruses in circulation and detect mutations in these or recombinations between different viral subtypes reported in other species.

In winter, he says, is common to increase cases of flu among the pig population and the UNAM has been made to isolate and monitor influenza viruses in pigs potentially transmissible to humans.

From 2009 to date virus found in pigs that have certain genes of human influenza and other bird coming. Cases like these have been detected in the United States.

Migratory waterfowl, such as ducks and herons ranging from Canada to the American Union, and sometimes Mexican lagoons are the main carriers of most subtypes reported.

Betancourt S?nchez, states that currently circulate in pigs three viral subtypes: H1N1, H3N2 and recombination of these two, which is the hemagglutinin 1 with neuraminidase 2 (H1N2), a third viral subtype.

He adds that some of the currently circulating have a new amino acid mutations in the neuraminidase gene, "which makes them resistant to the antiviral used in the pandemic of 2009."

If any of them were to mutate with other subtypes, warns, "may be able to infect humans, and available antivirals not work for tolerance to drugs."

Therefore indicates that one of the objectives is to provide timely FMVZ health authorities in Mexico to prevent possible outbreaks.

According to the researcher, to identify the likelihood of the virus being transmitted from pigs to humans, it is important to find out if there have antibodies for viral genes that share the subtypes of swine and human.

Explain that a pandemic like that of 2009, is required to observe three premises: "The virus has never infected humans, so they have no defenses (antibodies) that has the ability to replicate, and that has the potential to spread among this population. "

For example, concerns, waterfowl may have more than 100 viral subtypes, with potential risk to other species, including humans.