China: 2019nCov - Cases, Outbreak News and Information Week 8 (February 16 - February 22, 2020)

[Shiloh]

Source: http://m.stnn.cc/pcarticle/717824

Wuhan Virus Institute responds to 6 rumors
2020-02-19 20:01

On the evening of February 19th, the Wuhan Institute of Virology of the Chinese Academy of Sciences issued a "letter to all staff and graduate students", in response to six recent rumors, such as "new crown virus originated from artificial synthesis", "the virus was leaked from P4", "military Fang took over P4, "a researcher died because of a virus leak," "a graduate student is 'Patient Zero'," "a researcher's real-name reporting agency leader," and so on.

Wuhan Virus Institute reviewed the work done since the outbreak, such as quickly determining the entire genome sequence of the new crown virus, isolating the virus strain, and submitting the virus sequence to the WHO, etc., and said "looking back at the hard work of the past month or so, We have a clear conscience. "

Earlier, the Jiangsu Internet Police issued a message saying that the recent rumored account login IP is overseas. Please open your eyes and beware of being misled by others!

WeChat picture_20200219200045

The following is the full text of the open letter--

All staff and graduate students:

Since the outbreak of the new crown pneumonia epidemic, party members, cadres, workers, and graduate students of the institute have resolutely implemented the Party's central decision-making and the deployment of academic party groups, strictly guarded against the epidemic, and took the initiative to undertake scientific and technological research. But recently, Internet rumors have involved some rumors of our institute, such as "new crown virus originated from artificial synthesis", "the virus was leaked from P4", "the military took over P4", "a researcher died because of a virus leak", "a graduate student is 'Zero' Patients', "a researcher's real-name report to the leadership of the institute", etc., have caused continuous attention from all walks of life, causing great harm to our research staff who adhere to the front line of scientific research, and also seriously interfered with the emergency scientific research that I undertook during the "epidemic" task.

Since the outbreak, our institute has gone all out to carry out scientific research. Our colleagues and classmates responded to the call of the institute and took the initiative to abandon the Spring Festival holiday to overcome many difficulties, strictly implement the provisions of epidemic prevention and control and laboratory biosafety management, and race against time and night. Struggle in the front line of the "epidemic", and fulfill the responsibilities and responsibilities of scientific and technological workers in "innovating science and technology, serving the country and serving the people." The high-level biosafety cluster platform of our institute adheres to the purpose of opening up to domestic and foreign countries, and also provides a strong support for the relevant scientific research of New Coronaviruses at home and abroad.

On the evening of December 30, 2019, after receiving samples of unexplained pneumonia from the Jinyintan Hospital of Wuhan, our institute organized the forces overnight to tackle the problem for 72 consecutive hours. On January 2, 2020, the whole genome sequence of the new crown virus was determined. The virus strain was isolated on May 5. The national virus resource bank was put into storage and standardized preservation on January 9. As one of the designated agencies of the National Health Commission, the virus sequence was submitted to the World Health Organization on January 11. At the same time, a lot of work has been carried out in the areas of pathogen identification, virus traceability, pathogen detection, antiviral drugs and vaccine development, animal model establishment, etc., and good progress has been made.

In addition, as one of the designated institutions in Wuhan, our institute has participated in the pathogenic testing of new crown virus pneumonia. Since January 26, a total of about 4,000 throat swab samples have been detected from patients with suspected new crown pneumonia. A team of staff and graduate students supports the detection of pathogens in Huanggang City and contributes to epidemic prevention and control.

Looking back on the hard work of the past month or so, we have a clear conscience!

Epidemic situation At present, scientific and technological research is the front line of fighting the "epidemic". Let us closely unite around the Party Central Committee with Comrade Xi Jinping at its core, resolutely respond to the call of the Party Central Committee, and give full play to the role of the fighting fortress of Party organizations at all levels and the exemplary role of Party members and cadres in the scientific research frontline! I ask everyone to strengthen their confidence, eliminate interference, unite, and do a good job in scientific and technological research and epidemic prevention and control. Use solid results to reflect the mission and responsibilities of the "national team" in science and technology. Powerful technology support!

At present, China is cheering! Come on in Wuhan! Our Wuhan Virus Institute must also refuel!

All members of the leadership team of Wuhan Institute of Virology, Chinese Academy of Sciences

February 19, 2020

[Treyfish]

Coronavirus: Chief Physician of another Wuhan hospital infected

19 February, 2020 17:31
The chief physician at the Eighth Hospital in Wuhan has been tested positive for coronavirus and hospitalized, her condition assessed as critical.

Beijing Bao writes that a woman named Wang Ping is in the intensive care unit of the Jintan People's Hospital in Wuhan...https://report.az/en/other-countries...ital-infected/

[Treyfish]

New virus points out possibility of Chinese health authorities 'aerosol' infection

February 19, 2020 23:32China's health authorities have issued new guidelines on the new coronavirus, which, in addition to droplet and dense contact infections, which have previously been identified as the main routes of transmission, have been exposed to prolonged, high concentrations in closed environments. He pointed out that exposure to "aerosols" could result in "aerosol" transmission.

China's health authority, the National Board of Health and Health, released new guidelines on how to diagnose and treat the new coronavirus on the 19th....https://www3.nhk.or.jp/news/html/202..._news-main_001

[Treyfish]

On May 19, the Chinese government partially revised and announced the treatment policy for new types of pneumonia for the domestic market. Under certain conditions, it has been specified for the first time that infection can also be due to fine particulate "aerosols" floating in the air. Aerosol infection is considered to occur easily during medical procedures such as tracheal intubation, and further caution is required to prevent hospital-acquired infections..https://www.chunichi.co.jp/s/article...901002186.html

[Shiloh]

Wuhan coronavirus could cause male infertility: Chinese study
Chinese study finds Wuhan coronavirus could do heavy damage to male reproductive system
By Keoni Everington, Taiwan News, Staff Writer
2020/02/19 15:31

AIPEI (Taiwan News) — As scientists race to unravel the mysteries of the Wuhan coronavirus in an effort to stem its spread, a Chinese study has found the disease could lead to male infertility.

Fan Caibin, a urologist at Nanjing Medical University Affiliated Suzhou Hospital, on Feb. 12 posted the results of a scientific research project which found that the disease not only damages the lungs, but also the kidneys and testes, potentially leading to male infertility. The team summarized the clinical data of three previous studies, which included six patients, 41 patients, and 99 patients, respectively.,,,

Read more: https://www.taiwannews.com.tw/en/news/3878295

[Shiloh]

Source: https://www.upi.com/Top_News/World-N...3591582127195/

Mass animal die-off in China due to disinfectants, authorities say
By
Elizabeth Shim

Feb. 19 (UPI) -- China is using all available measures to stop the spread of the new strain of coronavirus that has killed more than 2,000 people, but some of the state's policies are provoking backlash and unintended consequences...

...The Chongqing Forestry Bureau said the 135 wild animals, representing 17 species, included wild boar, weasels, blackbirds and other bird species.

Following sampling and tests, Chinese authorities said some of the animals appeared to have been poisoned. Disinfectants may have been the cause of the deaths, they said. Authorities also ruled out the possibility the animals died from diseases, including COVID-19, bird flu or Newcastle disease...

[sharon sanders]

hat tip Shiloh to the change

hat tip to a FluTracker for the translation


Apparently diagnostic criteria for Hubei province changed again. 3rd change in 12 days.

Link to 6th version:
http://www.gov.cn/zhengce/zhengceku/...nt_5480948.htm


from page 4 of the attached pdf at the link above


SUSPECTED CASE - either fulfills one of the criteria under epidemiology and 2 under clinical; or no epidemiological evidence but fulfills all 3 of clinical signs

1 EPIDEMIOLOGY up to 14 days before symptom onset, has
1) history of travel to Wuhan or other places with reported cases, or reside in such areas
2) contact with confirmed case, by RT-PCR
3) contact with patients with fever or respiratory symptoms from Wuhan and adjacent areas or other areas with confirmed cases
4) part of a cluster with other confirmed cases

2 CLINICAL SIGNS
1) fever and/or respiratory symptoms
2) radiological evidence of coronavirus infection
3) normal or low white cell counts in early stage of illness, with low lymphocytes

CONFIRMED CASE

suspected case, plus either RT-PCR or genome sequence confirmation.

[Pathfinder]

Translation Google

Interpretation of "New Coronavirus Pneumonia Diagnosis and Treatment Scheme (Trial Version 6)"

Published: 2020-02-19Source : Medical Administration and Hospital Authority

On February 19, 2020, the National Health and Health Commission issued the "Diagnosis and Treatment of New Coronavirus Pneumonia (Trial Version 6)" (hereinafter referred to as the "Sixth Version"). The interpretation is as follows.
　　I. Route of
　　transmission The route of transmission is changed from "Respiratory droplets and contact transmission is the main transmission route" to "Respiratory droplets and close contact transmission is the main transmission route." The word "close" is added before "contact". Increase "the possibility of aerosol transmission in long-term exposure to high concentrations of aerosols in a relatively closed environment."
　　Second, the clinical manifestations of
　　patients with severe illness in addition to "rapidly progressing to acute respiratory distress syndrome, sepsis In addition to shock, difficult to correct metabolic acidosis and coagulopathy, "multi-organ failure" can also occur.
　　Laboratory tests, stressing that "in order to improve nucleic acid testing positive rate of sputum specimens is recommended as far as possible, intubating patients with lower respiratory tract secretions collection, submission as soon as possible after sample collection."
　　Third, the diagnostic criteria for
　　the sixth edition of the diagnostic criteria Cancel The difference between Hubei Province and Hubei Province. They are divided into two categories: "suspected cases" and "confirmed cases".
　　There are two cases of suspected cases. The first is "have any one of the epidemiological history, and meet any two of the clinical manifestations (fever and / or respiratory symptoms; with the imaging characteristics of the pneumonia mentioned above; the total number of white blood cells in the early stage of disease is normal or decreased, and the lymphocyte count is reduced). The second is "without a clear epidemiological history and conforms to 3 of the clinical manifestations (fever and / or respiratory symptoms; with the aforementioned imaging characteristics of pneumonia; the total number of white blood cells in the early stage of disease is normal or decreased, and the lymphocyte count is reduced).
　　Confirmed cases need to have a positive result of pathogenic evidence (real-time fluorescent RT-PCR detection of new coronavirus nucleic acid positive; or viral gene sequencing, highly homologous to known new coronavirus).
　　Fourth, the clinical classification is
　　still divided into "light, ordinary, heavy and critical", the arterial blood oxygen partial pressure (PaO ₂ ) / oxygen concentration (FiO ₂) ≤300mmHg (1mmHg = 0.133kPa) increased "Pao ₂ / FiO _{2 should} be corrected according to the following formula in high altitude (above 1000 meters) : PaO ₂ / FiO ₂  ? [Atmospheric Pressure (mmHg) / 760]".
　　"Pulmonary imaging showed significant progression of lesions> 50% within 24-48 hours" was managed as heavy.
　　V. Differential diagnosis: Differential diagnosis of
　　related diseases based on mild coronavirus infection and new coronavirus pneumonia.
　　For example, the mild manifestation of new coronavirus infection needs to be distinguished from other upper respiratory tract infections caused by other viruses; new coronavirus pneumonia is mainly distinguished from other known viral pneumonia and mycoplasma pneumoniae infections such as influenza virus, adenovirus, and respiratory syncytial virus.
　　It emphasizes that "for suspected cases, methods such as rapid antigen detection and multiplex PCR nucleic acid detection should be adopted as far as possible to detect common respiratory pathogens."
　　6. Case discovery and reporting
　　Delete "About Hubei Province's requirements for the treatment of clinically diagnosed cases".
　　The "suspected case" exclusion criterion was deleted, and the de-isolation criteria for suspected cases were consistent with the "de-isolation criteria".
　　Seven, treatment
　　1. Determine the treatment place according to the condition. Delete "suspected and confirmed cases" and replace it with "should be treated in isolated hospitals with effective isolation and protection conditions, and confirmed cases may be admitted to the same ward."
　　2. Antiviral therapy: Delete "No effective anti-coronavirus treatment is currently confirmed." In the trial drugs, add "chloroquine phosphate (500mg for adults, twice daily) and Abidol (200mg for adults, daily 3 times) "two drugs. Ribavirin is recommended in combination with interferon or lopinavir / ritonavir. The duration of trial of the drug is less than 10 days. It is recommended to further evaluate the efficacy of the currently tested drugs in clinical applications. It is not recommended to use 3 or more antiviral drugs at the same time, and the use of related drugs should be stopped when there are intolerable side effects.
　　3. Treatment of severe and critical cases. Add "Plasma Treatment for Rehabilitated Patients", which is recommended for patients with rapid disease progression, severe and critically ill patients. For usage and dosage, please refer to "Clinical Treatment Plan for Recovery Period of New Coronary Pneumonia Rehabilitation Patients (Trial Version)".
　　4. Other treatment measures: For critically ill patients with high inflammatory response, "extracorporeal blood purification technology can be considered if possible." Amended to "conditional can be considered using plasma exchange, adsorption, perfusion, blood / plasma filtration, etc. Extracorporeal blood purification technology. "
　　5. About traditional Chinese medicine treatment. Based on the in-depth observation and treatment of patients, on the basis of summarizing and analyzing TCM diagnosis and treatment programs throughout the country, combing and screening TCM treatment experience and effective prescriptions, combined with the issued "Recommendation for the use of traditional Chinese and western medicine in the treatment of pneumonitis infected by new coronavirus" Notice of Qingfei Paidu Decoction "," Diagnosis and Treatment of New Coronary Virus Pneumonia Severe and Critical Cases (Trial Version 2) "and" Specifications for the Management of Mild and Common Cases of New Coronavirus Pneumonia "etc. The pneumonia diagnosis and treatment plan (trial version of the fifth trial) was adjusted and supplemented. Continuing the staging of the entire process of the disease in the previous edition, the TCM treatment was divided into the medical observation period and the clinical treatment period (confirmed cases), and the clinical treatment period was divided into light, ordinary, heavy, critical, and recovery periods. The use of proprietary Chinese medicines is recommended during the medical observation period. The general prescription "Qingfei Paidu Decoction" is recommended during the clinical treatment period, and the light, common, heavy, critical, and recovery periods are explained from three aspects: clinical manifestations, recommended prescriptions and dosages, and administration methods. At the same time, specific usages of Chinese patent medicines (including traditional Chinese medicine injections) that are suitable for heavy and critical cases have been added to the plan. Different regions can refer to the recommended scheme for dialectical treatment according to the condition, local climate characteristics, and different physical conditions.
　　Eight, precautions after de-isolation and discharge The
　　criteria for de-isolation must meet the following 4 conditions:
　　1. The body temperature has returned to normal for more than 3 days;
　　2. The respiratory symptoms have improved significantly;
　　3. The pulmonary imaging shows that the acute exudative lesions have significantly improved absorption ;
　　4. nucleic twice respiratory specimens tested negative for (at least 1 day sampling interval).
　　Add "Post-discharge notes":
　　1. The designated hospitals should make contact with the primary medical institutions where the patients live, share medical records, and promptly push the discharged patients' information to the patient's jurisdiction or the residential committees and primary medical institutions.
　　2. After the patient is discharged from the hospital, due to the low immune function in the recovery period and the risk of infection with other pathogens, it is recommended that the self-health monitoring should be continued for 14 days, wearing a mask, and living in a well-ventilated single room conditionally to reduce the relationship with the family. Keep close contact, share meals and meals, do good hand hygiene, and avoid going out.
　　3. It is recommended to follow up and return to the hospital in the 2nd and 4th week after discharge.


 

 

Related Links: Notice on Issuing a New Coronavirus Pneumonia Diagnosis and Treatment Plan (Trial Version 6)

http://www.nhc.gov.cn/yzygj/s7652m/2...9bf637e9.shtml

[Shiloh]

Source: https://bingepost.com/a-beijing-dist...fection/36347/

A Beijing district govt quarantines 69 staff after one confirmed coronavirus an infection
Published 2 seconds ago
on February 19, 2020
By Team BingePost


A Beijing district official confirmed on Tuesday that one in all its authorities staff has been contaminated with the novel coronavirus (COVID-19), inflicting 69 extra in quarantine, however denied rumors that the an infection case has led to a shutdown of the district authorities.

The contaminated authorities worker was recognized with COVID-19 in delicate circumstances after he resumed work from the Spring Competition vacation when he traveled again to his hometown in North China’s Hebei Province to go to members of the family, Solar Shuo, head of the Xicheng district authorities, stated at a press convention on COVID-19 epidemic management in Beijing on Tuesday.

The worker confirmed no apparent symptom and his temperature remained regular when he obtained again to work on the frontline of preventive and management in opposition to the epidemic within the district till he was notified that one in all his kinfolk in his hometown was confirmed with COVID-19 an infection on February 11, Solar stated...

[Pathfinder]

Translation Google

[Wuhan Pneumonia] Absolutely not like flu! A picture to understand the new coronavirus is unusual

health
Written by: Heho Health
2020-02-19 07:24
Last updated:2020-02-19 12:48

The outbreak of Wuhan Pneumonia International is getting worse. Recently, there is a saying that "Wuhan pneumonia is almost the same as flu." Former Zhang Nanyi, a professor at the Institute of Microbiology and Immunology of Yangming University in Taiwan, disagreed. He pointed out that the characteristics of the new coronavirus are different In the previous SARS and MERS, how can it be compared with influenza viruses with completely different genes.

Professor Zhang Nanzhang, a former dean of the Machu Medical College in Taiwan, said that the new coronavirus that causes Wuhan pneumonia belongs to the RNA (+) virus, which is easily mutated in the host. Once a person is infected, it is difficult to recover. Many people need to be rescued. Of patients is enough to paralyze a city or even a country, so don’t mistake Wuhan pneumonia “it doesn’t seem to really kill a lot of people”, just think it ’s not as deadly as the flu, but it ’s not a fear; in fact it It's definitely not the same thing as the flu.
...
The number of people diagnosed with pneumonia in Wuhan is “moving upwards”, and the large patient population will bring down medical units.

Zhang Nanzhang pointed out that as of (15/2), there have been more than 60,000 patients with Wuhan pneumonia in the world. When the normal distribution curve rises, the number of deaths will increase, so the number of deaths has now reached more than 1368. People.

"But you will find that the most serious problem is that the number of people recovering has been very small, only a few thousand people have accumulated, but it has been more than 4 weeks, and the number of people in the continuous treatment of intermediate illness is still more than 50,000. We and I don't know how long this time will be delayed. "

These people may need a respirator or even Ye Kemian. Regardless of the respirator, the number of patients alone is so large. It is conceivable that even beds are not enough. How can they be treated carefully? "If the number of cases in Taipei suddenly increases due to a community infection, it will paralyze the entire city like Wuhan," Zhang said. "It is difficult for us to imagine the urgent situation in Wuhan now."

Professor Zhang Nanxuan emphasized that the most serious thing in the course of the disease is that the patients are stuck in the "ill" state. Except that the patients themselves are very distressed, the manpower and medical expenses required are huge. Just as Wuhan has now built two hospitals and even dispatched troops, the factories have stopped working. "The most difficult thing to solve is" panic ". The sick panic and the caregivers panic. The panic makes everyone rush to grab supplies and masks."
...
Next Zhang Nanzheng analyzed the possible normal distribution of the course of the flu. The total number of illnesses in the flu is high. Although the mortality rate is low, it still kills a lot of lives. In just two weeks, almost all people who are sick in the middle will move to the right and become fully recovered.
...
"The reason why we don't feel anything is because the disease is coming and going fast on the individual. After just 2 weeks, the patient will recover to health and return to work. The curve of the number of people who are cured will move to the right instead of stagnation like Wuhan pneumonia Don't move forward, "Zhang Nanxun pointed out.

He said with emotion, although it was said to stabilize the people and avoid panic, doctors can't claim that Wuhan pneumonia is similar to the flu. The severity is extraordinary. "

Zhang Nanxun said that it is not yet known whether the disease can be completely cured in the future. If the epidemic is prolonged, the death toll will continue to rise and the consequences will be serious. In addition, a coronavirus infection will have permanent damage to the body. As long as the lungs are inflamed, they will leave traces for a lifetime, unlike flu, which is unlikely to have sequelae. Therefore, Professor Zhang Nanxun appealed that Wuhan pneumonia must not be underestimated.

https://www.hk01.com/%E5%81%A5%E5%BA%B7/436254/%E6%AD%A6%E6%BC%A2%E8%82%BA%E7%82%8E-%E7%B5%95%E5%B0%8D%E4%B8%8D%E5%83%8F%E6%B5%81%E6%84%9F-%E4%B8%80%E5%BC%B5%E5%9C%96%E7%9C%8B%E6%87%82%E6%96%B0%E5%86%A0%E7%8B%80%E7%97%85%E6%AF%92%E4%B8%8D%E5%B0%8B%E5%B8%B8

[Shiloh]

Source: http://wjw.hubei.gov.cn/fbjd/dtyw/20..._2141274.shtml
Epidemic Situation of New Crown Pneumonia in Hubei Province on February 19, 2020
2020-02-20 06:33 | Hubei Provincial Health Committee

From 04:00 to 24:00 on February 19, 2020, 349 new cases of new coronary pneumonia were confirmed in the province, including: 615 in Wuhan, 5 in Xiantao, 3 in Shiyan, 3 in Suizhou, 2 in Xiangyang, and Huanggang City reduction of 5 cases, Ezhou reduction of 5 cases, Enshi Prefecture reduction of 5 cases, Tianmen City reduction of 13 cases, Xiaogan City reduction of 15 cases, Huangshi City reduction of 16 cases, Yichang City reduction of 16 cases, Jingzhou City reduction of 31 cases, Xianning City reduction 66 cases, 107 cases of nuclear reduction in Jingmen City.

There were 108 new deaths in the province, including 88 in Wuhan, 7 in Xiaogan, 2 in Huanggang, 2 in Yichang, 2 in Jingzhou, 1 in Huangshi, 1 in Xiangyang, and 1 in Ezhou. 1 case in Jingmen City, 1 case in Suizhou City, 1 case in Qianjiang City, and 1 case in Tianmen City.

There were 1209 new hospital discharges in the province, including 553 in Wuhan, 101 in Xiaogan, 90 in Huanggang, 64 in Xiangyang, 60 in Tianmen, 54 in Suizhou, 49 in Ezhou, and 43 in Xianning. There were 42 cases in Jingzhou, 37 cases in Huangshi City, 35 cases in Xiantao City, 23 cases in Shiyan City, 23 cases in Yichang City, 20 cases in Jingmen City, 9 cases in Qianjiang City, and 6 cases in Enshi Prefecture.

As of 24:00 on February 19, 2020, Hubei Province has reported a total of 62,013 new crown pneumonia cases, including: 45027 in Wuhan, 3329 in Xiaogan, 2839 in Huanggang, 1510 in Jingzhou, 1338 in Ezhou, and 1283 in Suizhou. Cases, 1167 cases in Xiangyang City, 967 cases in Huangshi City, 891 cases in Yichang City, 794 cases in Jingmen City, 766 cases in Xianning City, 641 cases in Shiyan City, 567 cases in Xiantao City, 473 cases in Tianmen City, 244 cases in Enshi Prefecture, Qianjiang City There were 185 cases and 10 cases in Shennongjia forest area.

A total of 10,337 cases were discharged from the hospital. The province has accumulated 2,029 deaths, including: 1585 cases in Wuhan, 89 cases in Xiaogan City, 87 cases in Huanggang City, 40 cases in Jingzhou City, 38 cases in Ezhou City, 34 cases in Jingmen City, 27 cases in Suizhou City, 27 cases in Yichang City, There were 26 cases in Huangshi City, 23 cases in Xiangyang City, 19 cases in Xiantao City, 12 cases in Tianmen City, 10 cases in Xianning City, 7 cases in Qianjiang City, 3 cases in Enshi Prefecture, and 2 cases in Shiyan City.

At present, 43,745 cases are still being treated in the hospital, of which 9128 cases are critically ill and 2050 cases are critically ill. They are all under isolation treatment at designated medical institutions. There were 3456 suspected cases, 880 were newly added on that day, 872 were excluded on that day, and 3334 were concentrated and isolated. A total of 214,093 close contacts were tracked, and 65,525 people are still undergoing medical observation.

[Ronan Kelly]

Epidemic Situation of New Crown Pneumonia in Hubei Province on February 19, 2020
Release time: 2020-02-20 06:35 Source: Hubei Provincial Health Committee [Font: Tai Zhong small ]
From 04:00 to 24:00 on February 19, 2020, 349 new cases of new coronary pneumonia were confirmed in the province, including: 615 in Wuhan, 5 in Xiantao, 3 in Shiyan, 3 in Suizhou, 2 in Xiangyang, and Huanggang City reduction of 5 cases, Ezhou reduction of 5 cases, Enshi Prefecture reduction of 5 cases, Tianmen City reduction of 13 cases, Xiaogan City reduction of 15 cases, Huangshi City reduction of 16 cases, Yichang City reduction of 16 cases, Jingzhou City reduction of 31 cases, Xianning City 66 cases, 107 cases of nuclear reduction in Jingmen City.

There were 108 new deaths in the province, including 88 in Wuhan, 7 in Xiaogan, 2 in Huanggang, 2 in Yichang, 2 in Jingzhou, 1 in Huangshi, 1 in Xiangyang, and 1 in Ezhou. 1 case in Jingmen City, 1 case in Suizhou City, 1 case in Qianjiang City, and 1 case in Tianmen City.

There were 1209 new hospital discharges in the province, including 553 in Wuhan, 101 in Xiaogan, 90 in Huanggang, 64 in Xiangyang, 60 in Tianmen, 54 in Suizhou, 49 in Ezhou, and 43 in Xianning. There were 42 cases in Jingzhou City, 37 cases in Huangshi City, 35 cases in Xiantao City, 23 cases in Shiyan City, 23 cases in Yichang City, 20 cases in Jingmen City, 9 cases in Qianjiang City, and 6 cases in Enshi Prefecture.

As of 24:00 on February 19, 2020, Hubei Province has reported a total of 62,013 new crown pneumonia cases, including: 45027 in Wuhan, 3329 in Xiaogan, 2839 in Huanggang, 1510 in Jingzhou, 1338 in Ezhou, and 1283 in Suizhou. Cases, 1167 cases in Xiangyang City, 967 cases in Huangshi City, 891 cases in Yichang City, 794 cases in Jingmen City, 766 cases in Xianning City, 641 cases in Shiyan City, 567 cases in Xiantao City, 473 cases in Tianmen City, 244 cases in Enshi Prefecture, Qianjiang City There were 185 cases and 10 cases in Shennongjia forest area.

A total of 10,337 cases were discharged from the hospital. The province has accumulated 2,029 deaths, including: 1585 cases in Wuhan, 89 cases in Xiaogan City, 87 cases in Huanggang City, 40 cases in Jingzhou City, 38 cases in Ezhou City, 34 cases in Jingmen City, 27 cases in Suizhou City, 27 cases in Yichang City, There were 26 cases in Huangshi City, 23 cases in Xiangyang City, 19 cases in Xiantao City, 12 cases in Tianmen City, 10 cases in Xianning City, 7 cases in Qianjiang City, 3 cases in Enshi Prefecture, and 2 cases in Shiyan City.

At present, 43,745 cases are still being treated in the hospital, of which 9128 cases are critically ill and 2050 cases are critically ill. They are all under isolation treatment at designated medical institutions. There were 3456 suspected cases, 880 were newly added on that day, 872 were excluded on that day, and 3334 were concentrated and isolated. A total of 214,093 close contacts were tracked, and 65,525 people are still undergoing medical observation.

http://www.hubei.gov.cn/zhuanti/2020/gzxxgzbd/zxtb/202002/t20200220_2141277.shtml

[sharon sanders]

Update on the epidemic situation of new coronavirus pneumonia as of 24:00 on February 19

Published: 2020-02-20Source : Health Emergency Office
　　At 04:00 on February 19, 31 provinces (autonomous regions, municipalities) and the Xinjiang Production and Construction Corps reported 394 new confirmed cases and 114 new deaths (108 in Hubei, Hebei, Shanghai, Fujian, Shandong, and Yunnan). And 1 in Shaanxi), and 1277 suspected cases were newly added.
　　1779 new cases were cured and discharged on the same day, 25,318 close contacts were released from medical observation, and 113 severe cases were reduced.
　　As of 24:00 on February 19, according to reports from 31 provinces (autonomous regions, municipalities) and the Xinjiang Production and Construction Corps, there were 56303 confirmed cases (among which, 11864 were severe cases), a total of 16,155 discharged patients were cured, and a total of 2118 died A total of 74,576 confirmed cases have been reported (one in each case in Jiangxi, Henan, and Yunnan Provinces), and 4,922 suspected cases have been reported. A total of 589,163 close contacts were tracked, and 126,363 close contacts were still in medical observation.
　　There were 349 new confirmed cases in Hubei (including 615 new cases in Wuhan, 13 new cases in 4 cities including Xiantao, and 10 cities and prefectures such as Jingmen, Xianning, etc.). Based on comprehensive analysis, cases with negative nucleic acid test results were subtracted from the confirmed cases, and a total of 279 cases were corrected. 1209 new cases were cured and discharged (553 cases in Wuhan), and 108 new death cases (88 cases in Wuhan). There were 49665 confirmed cases (37994 in Wuhan), of which 11,178 were severe cases (9689 in Wuhan). A total of 10,337 discharged patients were cured (5,448 in Wuhan), a total of 2,029 died (1,585 in Wuhan), and a total of 62,013 confirmed cases (45,027 in Wuhan). There were 880 new suspected cases (483 in Wuhan) and 3456 suspected cases (1940 in Wuhan).
　　A total of 99 confirmed cases were reported in Hong Kong, Macao and Taiwan: 65 cases in Hong Kong Special Administrative Region (5 cases discharged, 2 deaths), 10 cases in Macau Special Administrative Region (6 cases discharged), 24 cases in Taiwan (2 cases discharged, 1 case died ).


 

 

(Note: When quoted by the media, please mark "Information comes from the official website of the National Health and Health Commission.")

http://www.nhc.gov.cn/xcs/yqtb/202002/4dcfcb9b74ea4a408fc1d56d4db61f93.shtml

[Pathfinder]

Translation Google

Wuhan pneumonia is more severe than SARS and MERS! Authoritative expert Zhang Nanxun:
Coronavirus is getting smarter

Heho Health 2020/02/20 09:00 (1 hour ago)

Everyone mentioned new pneumonia, people were still very worried, especially recently, local death cases broke out in Taiwan, to further escalate the epidemic, and most people feel uneasy when walking on the road without wearing a mask. Many people have compared this epidemic with SARS 17 years ago, but Zhang Nanzhang, a professor of immunology in Taiwan, said that this new crown pneumonia is probably more serious than SARS and MERS.

Former Professor Yang Nanming of the Institute of Microbiology and Immunology of Yangming University said in an exclusive interview with HEHO Health that coronaviruses are "increasingly smarter." He compared the three most notorious coronaviruses since 2000, namely SARS, MERS, and this time nCoV-19 (new coronary pneumonia virus).

SARS AND MERS ARE BOTH LIMITED BECAUSE OF THEIR HIGH LETHALITY

"We always think that SARS is terrible, but looking at this picture, in the 8 months that SARS really raged, only 8098 people were attacked, and the fatalities were only 774. The fatality rate was as high as 9.6%, but it The total number of real deaths is not as high as we think. "

Then, Professor Zhang Nanzhang analyzed MERS with a fatality rate of 34.4%. From the perspective of transmission, MERS is probably not a too clever virus, because it kills its host too quickly, and it cannot increase the infection rate. Therefore, the scope of influence has been limited to the Middle East, and the total number of diagnosed people is only 2494.

NEW CORONAVIRUSES ARE GETTING SMARTER! DECREASING LETHALITY IS EVEN MORE TERRIFYING

Looking back at this new coronavirus, it can be found that its lethality is much lower than the other two. But it's especially scary because it doesn't look that deadly.

Professor Zhang Nanxun explained that the virus will become more and more intelligent. It now understands that letting its host die too quickly is not good for its own transmission and survival. Therefore, the new coronavirus reduces the lethality, increases the infectivity and speed, and makes it more Many people become their hosts.

IMPACT SURPASSES SARS AND MERS , NEW PNEUMONIA CONTINUES TO MUTATE IN THE HOST

How effective is this strategy? You can take a peek at the data. As of February 18, there were 72,530 cases worldwide with 1,870 deaths. According to the School of Public Health of Taiwan University, the fatality rate was about 3.02%.

"This is official data. There may be no cases that have not been checked out, so it should be underestimated. In any case, this number (1870) now exceeds the sum of MERS plus SARS fatalities (1632).

Moreover, so many people use the virus as a "lab", and the virus can mutate in it, be smarter to wait for change, and then upgrade to a new variant virus.

"Maybe its lethality will drop to as low as the flu in the future, but it will never become the flu." Professor Zhang pointed directly. Coronavirus is not like flu, leaving no traces after healing; it is not only difficult to heal, but also damages the lungs, causing the lungs to lose self-healing function. "Once you get the new coronavirus, you may still need to suffer from symptoms such as pulmonary fibrosis, osteonecrosis, or osteoporosis," Professor Zhang Nanyi pointed out.

Text / Lin Yizhang / He Yiting

https://times.hinet.net/news/22792817

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Authoritative Interview ｜ Academician Zhang Gaiping: How to detect new crown virus infection in two or three minutes


Zhang Gaiping is a member of the Chinese Academy of Engineering and the president of Henan Agricultural University. Since the outbreak of the new crown pneumonia epidemic, Zhang Gaiping led the team to focus on advantageous resources such as Henan Agricultural University, Zhengzhou University, and Henan Key Laboratory of Animal Immunology, and immediately launched research work on new coronavirus vaccines and detection technologies. The current project progress Smooth, and achieved the results of phased research.

成果 What are the results of these periodic studies? How accurate is the test strip that can quickly detect the new crown virus in three minutes? How effective is the animal test for the new crown virus vaccine antigen? When can I promote the application? On these issues, a reporter from Xinhua News Agency interviewed Academician Zhang Gaiping on February 18.

Q: What is the progress of the team you are currently leading in the development of new crown virus detection technology and vaccine development? What phase results have been achieved?

改 Zhang Gaiping: Since the infection of the new crown virus in Wuhan, we have always attached great importance to it. With the progress of this epidemic, we think we should do something because we have so many laboratories, have such good conditions, and have such a large team, so we decided to make some testing reagents and vaccines, because the testing reagents and vaccines Vaccines are important technical support and means in the prevention and control of viral diseases and infections.

上 We have made four kinds of detection reagents, namely PCR detection reagents, fluorescent quantitative PCR detection reagents, gene detection test strips (ie, nucleic acid detection test strips) and antibody detection test strips.

We have made three structural designs for the vaccine. The first structurally designed vaccine has been immunized (animal experiments) on February 8. The second and third vaccines will be available the day after tomorrow ( (February 20) I am going to (do) immunization (animal experiments), so the current effect after immunization has to be determined by our blood collection antibodies.

Q: What are the working principles of the two detection reagents, ordinary PCR detection reagents and fluorescent quantitative PCR detection reagents? What are the characteristics?

Zhang Gaiping: The so-called PCR, which is called polymerase chain reaction, is actually a gene amplification reaction. Because when you do diagnosis and monitoring, the amount of this virus is very small, if you want to be able to see it, you must expand it and increase its amount. Because genes have this advantage, you can see them by increasing their amount.

Therefore, the quantitative PCR and ordinary PCR are both detected by the amount of amplified genes, but the final method is to use the naked eye to judge, the results are different. Ordinary PCR requires running a gel to run the gel in order to see the bands. For fluorescent quantitative PCR, it is usually a special fluorescent quantitative PCR instrument, which is viewed by the machine. These are two different (detection reagents).

The precision of real-time PCR is higher, and the precision of ordinary PCR is not as high as that of real-time PCR.

Q: What are the working principles of the two test strips, nucleic acid test strips and antibody test strips? What are the advantages?

Zhang Gaiping: We have developed two kinds of test strips, one is a nucleic acid (test) test strip, a new type of coronavirus nucleic acid (detection) test strip, and the other is a new coronavirus antibody (detection) test strip.

Nucleic acid (detection) test paper, which is used to detect the nucleic acid of a virus. The presence of nucleic acid means that there is a virus. What is nucleic acid? Nucleic acids are the genes of viruses. Everyone talks about nucleic acids, and nucleic acids are the genes of viruses. Therefore, if a virus-specific gene is detected, it means that there is a virus.

Antibody test strips are used to detect antibodies produced in human blood after the virus infects people, so they are called new coronavirus antibody test strips. Then as long as you detect this specificity is the antibody against (new) coronavirus, it means that (new) coronavirus is infected, at least once.

比 Compared with the previous and existing detection methods, these two test strips have one thing in common. How to say it, use a few words.

One is 'fast', which means that the detection speed is fast. At present, the real-time PCR used in our hospitals basically takes one and a half hours, two hours, and (general) PCR may take several hours. Well, you like this nucleic acid test strip (required) for 20 minutes, which includes 2 to 3 minutes of reaction on the test strip, and this antibody test strip only takes 2-3 minutes.

Another 'Jane' is simple, and everything is simple. Basically, people who do not need professional technical knowledge can look at the instructions and simply look at the instructions to be able to operate. However, because this is a virus test, we recommend that you operate under the guidance of a doctor. In addition, 'Jane' also includes, not only easy operation, but also does not require special equipment.

The third is to say 'quasi', so it is more sensitive. Like this nucleic acid test strip, which can detect viruses with less than 10 copies, it is very, very sensitive. These PCRs (detection reagents) are currently used in hospitals and generally detect hundreds or 1,000 copies. Test strips (is it specific)? Because we need an evaluation control, the positive serum that we currently give to our hospital is 100% consistent.

Q: It only takes two or three minutes to detect the new crown virus infection. What does the successful development of this test strip mean? What's the positive point?

改 Zhang Gaiping: As you can see, in many places, especially Wuhan, there is a large backlog of suspected patients after the diagnosis is confirmed in Hubei, but if we have this antibody test strip, it will greatly speed up the process of diagnosis.

Especially the more you go down, the (local hospital) its conditions are not enough, the more it needs these detection reagents quickly and easily. Even if it is at the top (upper-level hospital), there is a problem of quantity at the top. He cannot detect it. At the bottom (low-level hospital), there is a problem that cannot be detected.

So with this test strip, you can, in many cases, greatly speed up the test process, greatly reduce the difficulty of the test, and even (make) the test more popular.

Q: Can the newly developed test strips achieve large-scale promotion and application under current conditions?

改 Zhang Gaiping: Because we have done some, you see, we have also done some clinical tests, and we have found that it is very good at present, and it is in full compliance with the clinical test results. Then the country generally produces (in large quantities). Scientific research institutions and universities will not apply for batch numbers for production, so companies are required to pick them up. They can go to the State Drug Administration to apply for batch numbers for production. The problem is that this application takes time.

Q: Can individuals perform the detection of the new crown virus? Still have to go to a professional agency?

Zhang Gaiping: If you say 'check' (using a test strip), anyone can check it, and anyone can operate it. This means that anyone can operate it technically. The recommendation is under the guidance of a doctor.

Q: How do you see the development trend of the new crown pneumonia epidemic in the next step?

Zhang Gaiping: Judging from the current measures, I think it is okay. Controlling the disease is okay. It wo n’t take too long, it wo n’t take too long. Why, because there are three main principles to control the spread of infectious diseases The three major principles of disease: control the source of infection, cut off the route of transmission, and protect vulnerable groups. Actually the first article is finished, the others are incidental, you have no source of infection, you have isolated the source of infection, and all are under control, it does not spread new viruses.

One more point, that is to say, our country has undergone 40 years of reform and development, because various aspects have greatly improved, including our scientific and technological response capabilities, drug response capabilities, and vaccine response capabilities if needed. This control is okay and will not take too long.



Reporter: Jiang Liang and Yuan Yueming

Editor: Hao Guangpeng Liu Yuxuan

Production by Audio and Video Department of Xinhua News Agency

http://www.xinhuanet.com/2020-02/20/c_1125602445.htm