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Influenza Other Respir Viruses
. 2024 Nov;18(11):e70021.
doi: 10.1111/irv.70021. Trends in COVID-19-Attributable Hospitalizations Among Adults With Laboratory-Confirmed SARS-CoV-2-COVID-NET, June 2020 to September 2023
Christopher A Taylor 1 , Michael Whitaker 1 , Monica E Patton 1 2 , Michael Melgar 1 , Pam Daily Kirley 3 , Breanna Kawasaki 4 , Kimberly Yousey-Hindes 5 , Kyle P Openo 6 7 8 , Patricia A Ryan 9 , Sue Kim 10 , Kathryn Como-Sabetti 11 , Dominic Solhtalab 12 , Grant Barney 13 , Brenda L Tesini 14 , Nancy E Moran 15 , Melissa Sutton 16 , H Keipp Talbot 17 , Kristen Olsen 18 , Fiona P Havers 1 2
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Background: Screening for SARS-CoV-2 infection among hospital admissions made interpretation of COVID-19 hospitalization data challenging as SARS-CoV-2-positive persons with mild or asymptomatic infection may be incorrectly identified as COVID-19-associated hospitalizations. The study objective is to estimate the proportion of hospitalizations likely attributable to COVID-19 among SARS-CoV-2-positive hospitalized patients.
Methods: A sample of laboratory-confirmed SARS-CoV-2-positive hospitalizations from the COVID-19-Associated Hospitalization Surveillance Network (COVID-NET) from June 2020 to September 2023 was analyzed, with a focus on July 2022 to September 2023. Likely COVID-19-attributable hospitalizations were defined as hospitalizations among SARS-CoV-2-positive non-pregnant adults ages ≥ 18 years with COVID-19-related presenting complaint, treatment, or discharge diagnosis.
Results: Among 44,816 sampled hospitalizations, 90% met the definition of likely COVID-19-attributable. Among the 9866 admissions occurring during July 2022 to September 2023, 86% were likely COVID-19-attributable; 87% had a COVID-19-related presenting complaint, 64% received steroids or COVID-19-related treatment, 47% had respiratory- and 10% had coagulopathy-related discharge diagnoses, and 39% had COVID-19 as the principal discharge diagnosis code. More than 70% met ≥ 2 criteria. Compared with likely COVID-19-attributable hospitalizations, SARS-CoV-2-positive patients who did not meet the case definition were more likely to be ages 18-49 years (27% vs. 13%), have no underlying medical conditions (14% vs. 4%), or be asymptomatic for COVID-19 upon admission (46% vs. 10%) (all p < 0.05).
Conclusions: Most hospitalizations among SARS-CoV-2-positive adults in a recent period were likely attributable to COVID-19. COVID-19-attributable hospitalizations are less common among younger SARS-CoV-2-positive hospitalized adults but still account for nearly three quarters of all admissions among SARS-CoV-2-positive adults in this age group.
Keywords: COVID‐19; epidemiology; hospitalizations; population‐based surveillance.
. 2024 Nov;18(11):e70021.
doi: 10.1111/irv.70021. Trends in COVID-19-Attributable Hospitalizations Among Adults With Laboratory-Confirmed SARS-CoV-2-COVID-NET, June 2020 to September 2023
Christopher A Taylor 1 , Michael Whitaker 1 , Monica E Patton 1 2 , Michael Melgar 1 , Pam Daily Kirley 3 , Breanna Kawasaki 4 , Kimberly Yousey-Hindes 5 , Kyle P Openo 6 7 8 , Patricia A Ryan 9 , Sue Kim 10 , Kathryn Como-Sabetti 11 , Dominic Solhtalab 12 , Grant Barney 13 , Brenda L Tesini 14 , Nancy E Moran 15 , Melissa Sutton 16 , H Keipp Talbot 17 , Kristen Olsen 18 , Fiona P Havers 1 2
Affiliations
- PMID: 39496579
- DOI: 10.1111/irv.70021
Background: Screening for SARS-CoV-2 infection among hospital admissions made interpretation of COVID-19 hospitalization data challenging as SARS-CoV-2-positive persons with mild or asymptomatic infection may be incorrectly identified as COVID-19-associated hospitalizations. The study objective is to estimate the proportion of hospitalizations likely attributable to COVID-19 among SARS-CoV-2-positive hospitalized patients.
Methods: A sample of laboratory-confirmed SARS-CoV-2-positive hospitalizations from the COVID-19-Associated Hospitalization Surveillance Network (COVID-NET) from June 2020 to September 2023 was analyzed, with a focus on July 2022 to September 2023. Likely COVID-19-attributable hospitalizations were defined as hospitalizations among SARS-CoV-2-positive non-pregnant adults ages ≥ 18 years with COVID-19-related presenting complaint, treatment, or discharge diagnosis.
Results: Among 44,816 sampled hospitalizations, 90% met the definition of likely COVID-19-attributable. Among the 9866 admissions occurring during July 2022 to September 2023, 86% were likely COVID-19-attributable; 87% had a COVID-19-related presenting complaint, 64% received steroids or COVID-19-related treatment, 47% had respiratory- and 10% had coagulopathy-related discharge diagnoses, and 39% had COVID-19 as the principal discharge diagnosis code. More than 70% met ≥ 2 criteria. Compared with likely COVID-19-attributable hospitalizations, SARS-CoV-2-positive patients who did not meet the case definition were more likely to be ages 18-49 years (27% vs. 13%), have no underlying medical conditions (14% vs. 4%), or be asymptomatic for COVID-19 upon admission (46% vs. 10%) (all p < 0.05).
Conclusions: Most hospitalizations among SARS-CoV-2-positive adults in a recent period were likely attributable to COVID-19. COVID-19-attributable hospitalizations are less common among younger SARS-CoV-2-positive hospitalized adults but still account for nearly three quarters of all admissions among SARS-CoV-2-positive adults in this age group.
Keywords: COVID‐19; epidemiology; hospitalizations; population‐based surveillance.