J Med Virol . SARS-CoV-2 variants and vulnerability at the global level

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J Med Virol


. 2022 Mar 11.
doi: 10.1002/jmv.27717. Online ahead of print.
SARS-CoV-2 variants and vulnerability at the global level


Vivek P Chavda ¹ , Aayushi B Patel ² , Darsh D Vaghasiya ²



Affiliations

• PMID: 35277864
• DOI: 10.1002/jmv.27717

Abstract

Numerous variants of "the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)" pandemic have evolved. Concerning viral variants may evolve with harmful susceptibility to the immunity established with the existing COVID-19 vaccination. These variations are more transmissible, induce relatively extreme illness, have evasive immunological features, decrease neutralization using antibodies from vaccinated persons, and are more susceptible to re-infection. "The centre for disease control and prevention (CDC)" has categorized SARS-CoV-2 mutations as variants of interest (VOI), variants of concern (VOC), and variants of high consequence (VOHC). At the moment, four variants of concern and many variants of interest have been defined and are required for constant observation. This review article summarizes various variants of SARS-CoV-2 surfaced with special emphasis on VOCs that are spreading across the world, as well as several viral mutational impacts and how these modifications alter the properties of the virus. This article is protected by copyright. All rights reserved.

Keywords: Delta Plus variant; Delta variant; Omicron Variant; SARS-CoV-2; mutation; vaccination; viral variant.