Viruses . Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2

[tetano]

Viruses


. 2022 Feb 17;14(2):418.
doi: 10.3390/v14020418.
Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2


Emily Clayton ¹ , Jacob Ackerley ¹ , Marianne Aelmans ¹ , Noor Ali ¹ , Zoe Ashcroft ¹ , Clara Ashton ¹ , Robert Barker ¹ , Vakare Budryte ¹ , Callum Burrows ¹ , Shanshan Cai ¹ , Alex Callaghan ¹ , Jake Carberry ¹ , Rebecca Chatwin ¹ , Isabella Davies ¹ , Chloe Farlow ¹ , Samuel Gamblin ¹ , Aida Iacobut ¹ , Adam Lambe ¹ , Francesca Lynch ¹ , Diana Mihalache ¹ , Amani Mokbel ¹ , Santosh Potamsetty ¹ , Zara Qadir ¹ , Jack Soden ¹ , Xiaohan Sun ¹ , Alexandru Vasile ¹ , Otto Wheeler ¹ , Mohammed A Rohaim ¹ , Muhammad Munir ¹



Affiliations

• PMID: 35216011
• DOI: 10.3390/v14020418

Free article

Abstract

The emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the importance of possible animal-to-human (zoonotic) and human-to-animal (zooanthroponotic) transmission and potential spread within animal species. A range of animal species have been verified for SARS-CoV-2 susceptibility, either in vitro or in vivo. However, the molecular bases of such a broad host spectrum for the SARS-CoV-2 remains elusive. Here, we structurally and genetically analysed the interaction between the spike protein, with a particular focus on receptor binding domains (RBDs), of SARS-CoV-2 and its receptor angiotensin-converting enzyme 2 (ACE2) for all conceivably susceptible groups of animals to gauge the structural bases of the SARS-CoV-2 host spectrum. We describe our findings in the context of existing animal infection-based models to provide a foundation on the possible virus persistence in animals and their implications in the future eradication of COVID-19.

Keywords: ACE2; SARS-CoV-2; eradication; transmission; zoonotic.