Eurosurv. Tracking SARS-CoV-2 lineage B.1.1.7 dissemination: insights from nationwide spike gene target failure (SGTF) and spike gene late detection (SGTL) data, Portugal, week 49 2020 to week 3 2021

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Tracking SARS-CoV-2 lineage B.1.1.7 dissemination: insights from nationwide spike gene target failure (SGTF) and spike gene late detection (SGTL) data, Portugal, week 49 2020 to week 3 2021

V?tor Borges^1,2 , Carlos Sousa^2,3 , Lu?s Menezes⁴ , Ant?nio Maia Gon?alves⁵ , Miguel Pic?o⁶ , Jos? Pedro Almeida⁷ , Margarida Vieita⁷ , Rafael Santos⁷ , Ana Rita Silva³ , Mariana Costa³ , Lu?s Carneiro³ , Pedro Casaca⁸ , Pedro Pinto-Leite⁸ , Andr? Peralta-Santos⁸ , Joana Isidro¹ , S?lvia Duarte⁹ , Lu?s Vieira⁹ , Raquel Guiomar¹⁰ , Susana Silva¹¹ , Baltazar Nunes¹¹ , Jo?o P Gomes

We show that the SARS-CoV-2 B.1.1.7 lineage is highly disseminated in Portugal, with the odds of B.1.1.7 proportion increasing at an estimated 89% (95% confidence interval: 83?95%) per week until week 3 2021. RT-PCR spike gene target late detection (SGTL) can constitute a useful surrogate to track B.1.1.7 spread, besides the spike gene target failure (SGTF) proxy. SGTL/SGTF samples were associated with statistically significant higher viral loads, but not with substantial shift in age distribution compared to non-SGTF/SGTL cases.


full article

https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2021.26.10.2100130#html_fulltext