Tweet
World J Radiol
. 2021 Jan 28;13(1):1-18.
doi: 10.4329/wjr.v13.i1.1.
Exploration of sex-specific and age-dependent COVID-19 fatality rate in Bangladesh population
Md Abdul Alim Al-Bari, Showna Hossain 1 , Md Kudrat-E Zahan 2
Affiliations
- PMID: 33574990
- PMCID: PMC7852349
- DOI: 10.4329/wjr.v13.i1.1
Abstract
Coronavirus disease-2019 (COVID-19), a respiratory tract infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global health emergency and a threat the entire world. The COVID-19 shows a wide spectrum of clinical presentations, severity, and fatality rates. Although the fatal outcomes of the COVID-19 pandemic are evident in all age groups, the most devastating impact on the health consequences and death from COVID-19 are associated with older adults, especially older men. COVID-19 pandemic is affecting different countries in the world especially in the 65+ years age male group. In fact, several genes involved into the regulation of the immune system are strategically placed on the X-chromosome and trigger a gendered mediated antiviral fight. The aim of this study is to explore and exploit whether a relationship exists between male sex and COVID-19 mortality and the relationship is age dependent. Herein we discuss the possible role of physiological and immunological sex differences into the higher morbidity and mortality of SARS-CoV-2 between females and males. Deciphering gender differences in COVID-19 offers a window into the principles of immunity against SARS-CoV-2 infection and this information on ageing dependent gender disparity might contribute to our current understanding of COVID-19 infection and disease treatment.
Keywords: Angiotensin-converting enzyme 2; COVID-19; Gender; Sex hormones; TLR7; TMPRSS2.