J Clin Invest . Recent endemic coronavirus infection is associated with less severe COVID-19

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J Clin Invest


. 2020 Sep 30;143380.
doi: 10.1172/JCI143380. Online ahead of print.
Recent endemic coronavirus infection is associated with less severe COVID-19


Manish Sagar ¹ , Katherine Reifler ¹ , Michael Rossi ¹ , Nancy S Miller ² , Pranay Sinha ¹ , Laura White ³ , Joseph P Mizgerd ¹



Affiliations

• PMID: 32997649
• DOI: 10.1172/JCI143380

Abstract

Four different endemic coronaviruses (eCoVs) are etiologic agents for the seasonal "common cold," and these eCoVs share extensive sequence homology with human severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we show that individuals with as compared to without a relatively recent documented eCoV were tested at greater frequency for respiratory infections but had similar rate of SARS-CoV-2 acquisition. Importantly, the patients with a previously detected eCoV had less severe coronavirus disease-2019 (COVID-19) illness. Our observations suggest that pre-existing immune responses against endemic human coronaviruses can mitigate disease manifestations from SARS-CoV-2 infection.

Keywords: Adaptive immunity; COVID-19; Cellular immune response.