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Posted January 04, 2024.
doi: https://doi.org/10.1101/2024.01.03.574008
Lai Wei, Shuiqing Liu, Shanshan Lu, Shengdong Luo, Xiaoping An, Huahao Fan, Weiwei Chen, Erguang Li, Yigang Tong, Lihua Song
Abstract
SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) can cause 100% mortality in human ACE2-transgenic mice, potentially attributable to late-stage brain infection. This underscores a spillover risk of GX_P2V into humans and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2-related viruses.
https://www.biorxiv.org/content/10.1...008v1.full.pdf
doi: https://doi.org/10.1101/2024.01.03.574008
Lai Wei, Shuiqing Liu, Shanshan Lu, Shengdong Luo, Xiaoping An, Huahao Fan, Weiwei Chen, Erguang Li, Yigang Tong, Lihua Song
Abstract
SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) can cause 100% mortality in human ACE2-transgenic mice, potentially attributable to late-stage brain infection. This underscores a spillover risk of GX_P2V into humans and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2-related viruses.
https://www.biorxiv.org/content/10.1...008v1.full.pdf