Tweet
Transplant Direct
. 2022 Jan 13;8(2):e1286.
doi: 10.1097/TXD.0000000000001286. eCollection 2022 Feb.
Solid Organ Transplantation From SARS-CoV-2-infected Donors to Uninfected Recipients: A Single-center Experience
Channa R Jayasekera 1 , Holenarasipur R Vikram 2 , Zeeshan Rifat 3 , Josiah Wagler 3 , Keita Okubo 3 , Brandon R Braaksma 3 , Jack W Harbell 3 , Caroline C Jadlowiec 3 , Nitin N Katariya 3 , Amit K Mathur 3 , Adyr Moss 3 , K Sudhakar Reddy 3 , Andrew Singer 3 , Robert Orenstein 2 , Christopher F Saling 2 , Maria T Seville 2 , Girish K Mour 4 , Hugo E Vargas 1 , Thomas J Byrne 1 , Winston R Hewitt Jr 3 , Bashar A Aqel 1
Affiliations
- PMID: 35047665
- PMCID: PMC8759616
- DOI: 10.1097/TXD.0000000000001286
Abstract
Background: The risk of donor-derived severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in solid organ (heart, lung, liver, kidney, pancreas, and intestine) transplant recipients is poorly understood. Since hematogenous transmission of SARS-CoV-2 has not been documented to date, nonlung solid organs might be suitable for transplantation since they likely portend a low risk of viral transmission.
Methods: Abdominal solid organs from SARS-CoV-2-infected donors were transplanted into uninfected recipients.
Results: Between April 18, 2021, and October 30, 2021, we performed transplants of 2 livers, 1 simultaneous liver and kidney, 1 kidney, and 1 simultaneous kidney and pancreas from SARS-CoV-2-infected donors into 5 uninfected recipients. None of the recipients developed SARS-CoV-2 infection or coronavirus disease 2019, and when tested, allograft biopsies showed no evidence of SARS-CoV-2 RNA.
Conclusions: Transplanting nonlung organs from SARS-CoV-2-infected donors into uninfected recipients demonstrated no evidence of virus transmission.