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Zhonghua Yu Fang Yi Xue Za Zhi. 2020 Feb 17;54(0):E005. doi: 10.3760/cma.j.issn.0253-9624.2020.0005. [Epub ahead of print] [Analysis of the first cluster of cases in a family of novel coronavirus pneumonia in Gansu Province].
[Article in Chinese; Abstract available in Chinese from the publisher]
Bai SL1, Wang JY1, Zhou YQ1, Yu DS2, Gao XM1, Li LL1, Yang F1.
Author information
Abstract
in English, Chinese
The epidemiological history and clinical characteristics of 7 cases of COVID-19 and 1 case of close contact in the first family aggregation epidemic of COVID-19 in Gansu Province were analyzed. The first patient A developed on January 22, 2020, with a history of residence in Wuhan, and confirmed severe cases of NCP on January 24, 2020; patient B, on January 23, 2020, diagnosed on January 31, severe cases; patient C, asymptomatic, diagnosed on January 27; patient D, asymptomatic, diagnosed on January 27; patient E, on January 24, diagnosed on January 28; patient F, asymptomatic, diagnosed on January 31; Patient G was asymptomatic and was diagnosed on January 31. In close contact, H was asymptomatic, PCR test was negative and asymptomatic, and he was discharged early. Among the 7 patients, 1 case died of (B) aggravation, and the other patients' condition was effectively controlled after active treatment. Except for the discharged cases, 5 cases were positive for COVID-19 specific IgM antibody and 1 case was negative. In this clustering outbreak, 4 patients remained asymptomatic, but PCR and IgM antibodies were positive, indicating that asymptomatic patients may be the key point to control the epidemic. Specific IgM antibody screening for patients whose pharyngeal swab nucleic acid test is negative but with ground glass-like lung lesions is very important for early detection and early isolation.
KEYWORDS:
Family cluster; Immunologlobulin M; Novel coronavirus pneumonia; Polymerase chain reaction
PMID: 32064855 DOI: 10.3760/cma.j.issn.0253-9624.2020.0005