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**HenryN** · May 26, 2009, 07:17 AM

Re: Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

Just a moment...

http://www.sciencemag.org/cgi/data/1176225/DC1/1

**JJackson** · May 26, 2009, 09:00 AM

Re: Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

Originally posted by niman View Post

http://www.sciencemag.org/cgi/data/1176225/DC1/1

Very last plot in this one (blue and green blobs). What am I looking at?

**gsgs** · May 26, 2009, 09:17 AM

Re: Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

thanks.

maybe one of thee is the Thailand pig, I'll check

A/Swine/Chachoengsao/NIAH587/2005(H1N1)
A/Swine/Chonburi/NIAH589/2005(H1N1)
A/Swine/Miyazaki/1/2006(H1N2)

nothing special about the swine

Code:

52 >A/swine-flu/index/2009-02-01(H1N1)                  
  1:177,136,140,483,163,507, 22,188   A/swine/Hong Kong/5190/99(H3N2)
  2:158, 63,170,488,176,506,135,182   A/Texas/UR06-0356/2007(H3N2)
  3:153, 82,164,482,157,503,118,177   A/Russia/WO0200884/72(H3N2)
  4:148,105,165,364,154,509,114,163   A/Japan/305/57(H2N2)
  5:147,105,166,363,150,509,112,157   A/Index/1957(H2N2)
 17: 96,131, 66,468,164,430, 89,291   A/pintail/Alaska/779/2005(H3N8)
 21:151,106,118,484,162,496, 66,302   A/Ck/Germany/n/1949(H10N7)
 22:154,135,116,492,162,500, 80,148   A/fowl/Dobson/1927(H7N7)

 65:177,195,182,152, 99,515,121,128   A/swine/Miyazaki/1/2006(H1N2)
 24:164,145,143,146,166, 92, 42,195   A/swine/Chonburi/NIAH589/2005(H1N1)
 25:163,145,143,146,166, 92, 42,195   A/swine/Chachoengsao/NIAH587/2005(H1N1)

 31:158,127,125,245,158, 80, 49,166   A/swine/Germany/2/1981(H1N1)=1578
 32:153,144,110,358,170,148, 87,158   A/Bar-h Gs/Qinghai/62/05(H5N1)
 33:146,108,105,364,159,134, 71,156   A/Ck/Scotland/1959(H5N1)
 38: 48, 59, 57,250,  0,250,  0,  0   A/swine/Minnesota/SG-00241/2007(H1N1)
 39: 29, 35, 43, 47, 31,505,110, 41   A/Turkey/MO/24093/99(H1N2)
 40: 29, 33, 36,250,  0,250,  0,  0   A/mallard duck/South Dakota/Sg-00125/2007(H3N2)
 41: 32, 37, 43,502, 33,505,123, 34   A/Swine/Texas/4199-2/98(H3N2)
 42: 38, 37, 42,484, 32,505,121, 87   A/swine/Korea/CY04/2007(H3N2)
 43: 47, 50, 57,250,  0,250,  0,  0   A/swine/Minnesota/SG-00240/2007(H1N1)
 44: 46, 49,  0, 63,  0,204,127,  0   A/swine/Ohio/C62006/06(H1N1)
 45: 49, 50, 56, 62, 55,199,120, 54   A/swine/Ohio/24366/07(H1N1)
 46: 49, 50, 56, 61, 54,199,120, 50   A/swine/OH/511445/2007(H1N1)
 47: 48, 50, 56,250,  0,250,  0,  0   A/swine/Illinois/SG-00244/2007(H1N1)
 48: 50, 40, 59, 52, 36,101, 56, 39   A/******-match/1-2/07(H3N2)
 58: 50, 53, 53,250,  0,250,  0,  0   A/swine/Minnesota/SG-00238/2006(H1N1)
 59: 45, 47, 45, 91, 44,200,124, 51   A/Iowa/CEID23/2005(H1N1)
 60: 33, 30, 44, 52, 36,201,119, 43   A/Wisconsin/10/98(H1N1)
 61: 72, 44,182,131, 50,205,123,107   A/swine/Ontario/53518/03(H1N1)
 62:173, 58,190,123, 70,209,130, 98   A/swine/Ontario/23866/04(H1N1)
 71:135,180,157,172,109,162,103,128   A/swine/Jamesburg/1942(H1N1)
 72:141,182,154,167,104,174,106,131   A/swine/Ohio/23/1935(H1N1)
 73:136,182,156,175,112,158,107,131   A/swine/1931(H1N1)
 74:125,176,155,182,120,167, 88,143   A/Brevig Mission/1/1918(H1N1)
 76:145,177,157,216,150,192,110,157   A/Hickox/1940(H1N1)
 77:146,186,164,226,155,192,116,155   A/Denver/57(H1N1)
 78:147,182,165,222,151,192,106,155   A/Index/1977(H1N1)
 81:164,192,171,235,157,216,125,178   A/Kansas/UR06-0068/2007(H1N1)

**gsgs** · May 26, 2009, 11:05 PM

Re: Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

Just a moment...

http://www.sciencemag.org/cgi/rapidpdf/1176225v1.pdf

page 2

> A/Thailand/271/2005 contains genes from both North American and Eurasian
> swine influenza lineages(29) indicating previous reassortment between
> these two swine virus lineages

--------edit---------

that event however is very distant to ****** and has nothing to do with it.

> Since the outbreak began, virologists have wondered how Eurasian genes got into a North American pig.
> Live pigs are moved through the Americas fairly easily, but rarely are legally moved across oceans,
> because they carry diseases. Even a single breeding boar must be tested and quarantined.
> Now that the mixed genes have been found in Asia, it is possible that they came from a
> North American pig that was taken there. There is little flu surveillance of pigs in much of
> the world, and even in the United States it is “not very systematic,” Dr. Cox said.

that conclusion may be right, but "Now that the mixed genes have been found in Asia, "
does not support it.

--------------------------------------

2007: Komadina N; Roque V; Thawatsupha P; Rimando-Magalong J; Waicharoen S; Bomasang E; Sawanpanyalert P; Rivera M; Iannello P; Hurt A C; Barr I G
Genetic analysis of two influenza A (H1) swine viruses isolated from humans in Thailand and the Philippines.
Virus genes 2007;35(2):161-5.

Influenza viruses A/Philippines/341/2004 (H1N2) and A/Thailand/271/2005 (H1N1) were isolated from two males, with mild influenza providing evidence of sporadic human infection by contemporary swine influenza. Both viruses were antigenically and genetically distinct from influenza A (H1N1 and H1N2) viruses that have circulated in the human population. Genetic analysis of the haemagglutinin genes found these viruses to have the highest degree of similarity to the classical swine H1 viruses circulating in Asia and North America. The neuraminidase gene and the internal genes were found to be more closely related to viruses circulating in European swine, which appear to have undergone multiple reassorting events. Although transmission of swine influenza to humans appears to be a relatively rare event, swine have been proposed as the intermediate host in the generation of potential pandemic influenza virus that may have the capacity to cause human epidemics resulting in high morbidity and mortality.

-----------------------------------------------

closest match in HA is A/swine/Tennessee/2/1977(H1N1)

27 years ! The 11 years gap of ******-anchestry surveillance looks small
compared to this. Swine viruses evolve and replicate on some farms
for decades unsurveilled and almost isolated from the rest
of swinefluhood. Thus avoiding these bottlenecks which we see
in human influenza evolution and which limit the diversity in circulating
human strains.
Swine serve as a big genetic reservoir for influenza, from which occasionally
new viruses can emerge and jump to humans.

**beudant** · June 15, 2009, 08:40 PM

Re: Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

Originally posted by gsgs View Post

http://www.sciencemag.org/cgi/rapidpdf/1176225v1.pdf
page 2

> A/Thailand/271/2005 contains genes from both North American and Eurasian
> swine influenza lineages(29) indicating previous reassortment between
> these two swine virus lineages

--------edit---------

that event however is very distant to ****** and has nothing to do with it.

> Since the outbreak began, virologists have wondered how Eurasian genes got into a North American pig.
> Live pigs are moved through the Americas fairly easily, but rarely are legally moved across oceans,
> because they carry diseases. Even a single breeding boar must be tested and quarantined.
> Now that the mixed genes have been found in Asia, it is possible that they came from a
> North American pig that was taken there. There is little flu surveillance of pigs in much of
> the world, and even in the United States it is ?not very systematic,? Dr. Cox said.

that conclusion may be right, but "Now that the mixed genes have been found in Asia, "
does not support it.

I just saw a show on Discovery Channel called "Pig Bomb" that was about the explosion of wild pigs in the U.S. It turns out that someone brought Eurasian wild boars over and released them into the wild in the 1980's or 1990's. The infusion of Eurasian wild boars has made the U.S. wild pigs tougher and they're spreading very quickly.

Could it be that swine flu is not from domestic pigs but from wild pigs in the U.S./Mexico?

**AlaskaDenise** · June 15, 2009, 09:00 PM

Re: Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

It turns out that someone brought Eurasian wild boars over and released them into the wild in the 1980's or 1990's.

Wild boars have been in the US prior to the 80s. I remember them along the California coast in the mid 60s - in the Big Sur area. They might have caught human influenza from contents of the garbage cans they overturned. Nasty large animals.

.

**beudant** · June 16, 2009, 08:39 AM

Re: Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

Originally posted by AlaskaDenise View Post

Wild boars have been in the US prior to the 80s.

Yes, they have been in the U.S. for hundreds of years but only recently has the Eurasian wild boar been introduced, (possibly re-introduced).

From the previous posts...

"Since the outbreak began, virologists have wondered how Eurasian genes got into a North American pig."

...it seemed that there is some mystery as to how the Eurasian genes appeared in North American pigs. I was just suggesting a method of transport.

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Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

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