Re: Canada - FluWatch Pandemic (H1N1) 2009 virus Surveillance Week 6
February 7 to February 13, 2010 (Week 6)
Posted 2010-02-19
Weekly and cumulative numbers of hospitalized cases, ICU admissions and deaths among Pandemic H1N1 2009 confirmed cases, Canada, to February 13, 2010<SUP>?</SUP>
<TABLE class="widthFull fontSize85" cellSpacing=0 cellPadding=2 border=1><TFOOT><TR><TD colSpan=10><SUP id=star>*</SUP>Based on reporting date.
<SUP id=dstar>**</SUP>Based on epidemiological date, hospitalization date, death date and reporting date.
<SUP>1</SUP> Aggregate counts were reported this week.
? Note that due to reporting delays, some PTs reported retrospectively on first and second wave cases.
</TD></TR></TFOOT><TBODY><TR class=alignCenter><TH class=bg-colour-blue scope=col rowSpan=2>Province/
Territory
</TH><TH class=bg-colour-blue scope=colgroup colSpan=3>Week 6
(February 7 to February 13, 2010)*
</TH><TH class=bg-colour-blue scope=colgroup colSpan=3>From August 30, 2009 to
February 13, 2010**
</TH><TH class=bg-colour-blue scope=colgroup colSpan=3>From April 12 to August 29, 2009**</TH></TR><TR class=alignCenter><TH class=bg-colour-blue scope=col>Hospitalized cases</TH><TH class=bg-colour-blue scope=col>ICU admissions</TH><TH class=bg-colour-blue scope=col>Deaths</TH><TH class=bg-colour-blue scope=col>Hospitalized cases</TH><TH class=bg-colour-blue scope=col>ICU admissions</TH><TH class=bg-colour-blue scope=col>Deaths</TH><TH class=bg-colour-blue scope=col>Hospitalized cases</TH><TH class=bg-colour-blue scope=col>ICU admissions</TH><TH class=bg-colour-blue scope=col>Deaths</TH></TR><TR><TH class=bg-colour-blue scope=row>BC<SUP>1,?</SUP></TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD><TD class=alignCenter>1009</TD><TD class=alignCenter>135</TD><TD class=alignCenter>50</TD><TD class=alignCenter>49</TD><TD class=alignCenter>19</TD><TD class=alignCenter>6</TD></TR><TR><TH class=bg-colour-blue scope=row>AB</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1147</TD><TD class=alignCenter>210</TD><TD class=alignCenter>64</TD><TD class=alignCenter>129</TD><TD class=alignCenter>29</TD><TD class=alignCenter>7</TD></TR><TR><TH class=bg-colour-blue scope=row>SK</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>44</TD><TD class=alignCenter>40</TD><TD class=alignCenter>11</TD><TD class=alignCenter>23</TD><TD class=alignCenter>12</TD><TD class=alignCenter>4</TD></TR><TR><TH class=bg-colour-blue scope=row>MB</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>166</TD><TD class=alignCenter>18</TD><TD class=alignCenter>4</TD><TD class=alignCenter>213</TD><TD class=alignCenter>43</TD><TD class=alignCenter>7</TD></TR><TR><TH class=bg-colour-blue scope=row>ON</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1444</TD><TD class=alignCenter>248</TD><TD class=alignCenter>103</TD><TD class=alignCenter>399</TD><TD class=alignCenter>69</TD><TD class=alignCenter>25</TD></TR><TR><TH class=bg-colour-blue scope=row>QC</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>2490</TD><TD class=alignCenter>361</TD><TD class=alignCenter>81</TD><TD class=alignCenter>572</TD><TD class=alignCenter>104</TD><TD class=alignCenter>27</TD></TR><TR><TH class=bg-colour-blue scope=row>NB<SUP>1</SUP></TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>161</TD><TD class=alignCenter>33</TD><TD class=alignCenter>8</TD><TD class=alignCenter>2</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>NS</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>276</TD><TD class=alignCenter>42</TD><TD class=alignCenter>6</TD><TD class=alignCenter>17</TD><TD class=alignCenter>8</TD><TD class=alignCenter>1</TD></TR><TR><TH class=bg-colour-blue scope=row>PE</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>49</TD><TD class=alignCenter>9</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>NL</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>274</TD><TD class=alignCenter>51</TD><TD class=alignCenter>18</TD><TD class=alignCenter>3</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>YT</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>15</TD><TD class=alignCenter>3</TD><TD class=alignCenter>3</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>NT</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>46</TD><TD class=alignCenter>7</TD><TD class=alignCenter>1</TD><TD class=alignCenter>6</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>NU</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>6</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>74</TD><TD class=alignCenter>6</TD><TD class=alignCenter>1</TD></TR><TR><TH class=bg-colour-blue scope=row>Canada</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD><TD class=alignCenter>7127</TD><TD class=alignCenter>1157</TD><TD class=alignCenter>349</TD><TD class=alignCenter>1488</TD><TD class=alignCenter>292</TD><TD class=alignCenter>78</TD></TR></TBODY></TABLE>
Descriptive characteristics of laboratory-confirmed Canadian pandemic H1N1 2009 hospitalized cases, ICU-admitted cases and deaths with core information available, reported to PHAC as of February 13, 2010<SUP><SUP>?</SUP> </SUP>
<TABLE class=fontSize85 cellSpacing=0 cellPadding=2 border=1><TBODY><TR class=alignCenter><TD rowSpan=2></TD><TH class=bg-colour-blue colSpan=3>From April 12 to August 29, 2009</TH><TH class=bg-colour-blue colSpan=3>From August 30, 2009 to February 13, 2010</TH><TH class=bg-colour-blue colSpan=3>Cumulative: From
April 12, 2009 to February 13, 2010
</TH></TR><TR class=alignCenter><TH class=bg-colour-blue>Hospitalized cases (n=1488)</TH><TH class=bg-colour-blue>ICU-admitted
(n=292)
</TH><TH class=bg-colour-blue>Deaths
(n=78)
</TH><TH class=bg-colour-blue>Hospitalized
cases (n=6674)
</TH><TH class=bg-colour-blue>ICU-admitted
(n=1157)
</TH><TH class=bg-colour-blue>Deaths
(n=345)
</TH><TH class=bg-colour-blue>Hospitalized
cases
(n=8162)
</TH><TH class=bg-colour-blue>ICU-admitted
(n=1449)
</TH><TH class=bg-colour-blue>Deaths
(n=423)
</TH></TR><TR><TH class="bg-colour-blue alignLeft">Females, %</TH><TD class=alignCenter>51.3</TD><TD class=alignCenter>57.2</TD><TD class=alignCenter>62.8</TD><TD class=alignCenter>49.7</TD><TD class=alignCenter>49.7</TD><TD class=alignCenter>46.7</TD><TD class=alignCenter>50.0</TD><TD class=alignCenter>51.2</TD><TD class=alignCenter>49.6</TD></TR><TR><TH class="bg-colour-blue alignLeft">Median age</TH><TD class=alignCenter>23.0</TD><TD class=alignCenter>37.0</TD><TD class=alignCenter>51.0</TD><TD class=alignCenter>30.0</TD><TD class=alignCenter>47.0</TD><TD class=alignCenter>54.0</TD><TD class=alignCenter>29.0</TD><TD class=alignCenter>46.0</TD><TD class=alignCenter>53.0</TD></TR><TR><TH class="bg-colour-blue alignLeft">Aboriginal status<SUP>1</SUP>, % </TH><TD class=alignCenter>20.0-27.7</TD><TD class=alignCenter>16.1-21.9</TD><TD class=alignCenter>11.5-17.3</TD><TD class=alignCenter>4.6-6.1</TD><TD class=alignCenter>5.9-7.8</TD><TD class=alignCenter>6.1-8.9</TD><TD class=alignCenter>7.4-10.0</TD><TD class=alignCenter>7.9-10.6</TD><TD class=alignCenter>7.1-10.4</TD></TR><TR><TH class="bg-colour-blue alignLeft">Underlying medical
conditions<SUP>2</SUP>, %
</TH><TD class=alignCenter>47.5
(652/1373)
</TD><TD class=alignCenter>60.2
(162/269)
</TD><TD class=alignCenter>73.3
(55/75)
</TD><TD class=alignCenter>58.4
(1884/3226)
</TD><TD class=alignCenter>72.9
(655/899)
</TD><TD class=alignCenter>84.2
(240/285)
</TD><TD class=alignCenter>55.1
(2536/4599)
</TD><TD class=alignCenter>69.9
(817/1168)
</TD><TD class=alignCenter>81.9
(295/360)
</TD></TR><TR><TH class="bg-colour-blue alignLeft">Pregnancy<SUP>3</SUP>, %</TH><TD class=alignCenter>27.6
(75/272)
</TD><TD class=alignCenter>19.7
(15/76)
</TD><TD class=alignCenter>28.6
(4/14)
</TD><TD class=alignCenter>18.5
(188/1018)
</TD><TD class=alignCenter>8.4
(15/178)
</TD><TD class=alignCenter>0.0
(0/36)
</TD><TD class=alignCenter>20.4
(263/1290)
</TD><TD class=alignCenter>11.8
(30/254)
</TD><TD class=alignCenter>8.0
(4/50)
</TD></TR><TR><TD colSpan=10><SUP>1 </SUP>ince Aboriginal status is not reported by two provinces (which comprise 23% of the Aboriginal population) two methods were used to calculate proportions: one proportion was calculated by including ON and NS cases in the denominator (which is an underestimate of the true proportion); while the other proportion was calculated by excluding ON and NS cases in the denominator (which is an overestimate).
<SUP>2 </SUP>Proportion of cases with at least one underlying medical condition (excluding pregnancy) among those for whom the information was available. Please note that results may differ slightly compared to the previous weeks due to updates in the national database.
<SUP>3 </SUP>Percent of pregnant women among women 15 to 44 years of age.
? All cases admitted to ICU are included in the hospitalization count; however, not all the fatal cases have been hospitalized before dying.
</TD></TR></TBODY></TABLE>
Overall Influenza Summary - Week 6 (February 7 to February 13, 2010)
During week 6, all influenza indicators continued to decline compared to the previous week and were still considerably under the expected level for this time of the year. Only 0.24% of the specimens tested were positive for influenza A. Three out of four (75%) of the positive influenza A subtyped specimens were pandemic H1N1 2009 this week.
In week 6, nineteen regions in BC, AB, MB, ON, QC, NS & NU reported sporadic activity, while thirty-five regions reported no activity in BC, AB, SK, MB, ON, QC, NB, PE, NS, NL, YT & NT. The 5 influenza outbreaks reported this week were all in schools (NS).

<TABLE class=widthFull cellSpacing=0 cellPadding=0><TBODY><TR class=alignCenter><TD colSpan=2>Map of overall Influenza activity level by provinces and territories, Week 6, Canada
</TD></TR><TR class=alignCenter><TD>
</TD><TD><TABLE cellSpacing=0 cellPadding=1 border=0><TBODY><TR><TD align=middle><TABLE class=border-lite cellSpacing=1 cellPadding=1><TBODY><TR align=middle><TD>No Data </TD><TD>
</TD></TR><TR class=alignCenter><TD>No Activity</TD><TD>
</TD></TR><TR class=alignCenter><TD>Sporadic Activity</TD><TD>
</TD></TR><TR align=middle><TD>Localized Activity</TD><TD>
</TD></TR><TR align=middle><TD>Widespread
Activity
</TD><TD>
</TD></TR></TBODY></TABLE></TD></TR></TBODY></TABLE></TD></TR><TR><TD class=fontSize85 colSpan=2>Note: Influenza activity levels, as represented on this map, are assigned and reported by Provincial and Territorial Ministries of Health, based on laboratory confirmations, sentinel ILI rates (see graphs and tables) and reported outbreaks. Please refer to detailed definitions on the last page. For areas where no data is reported, late reports from these provinces and territories will appear on the FluWatch website.
</TD></TR></TBODY></TABLE>
Number of influenza surveillance regions<SUP>?</SUP> reporting widespread or localized influenza activity,
Canada, by report week, 2009-2010 (N=54)


? sub-regions within the province or territory as defined by the provincial/territorial epidemiologist. Graph may change as late returns come in.

Overall Number of Influenza Outbreaks, Canada, by Report Week, 2009-2010


Note that this was the first year that all the provinces and territories were reporting on influenza outbreaks in schools (greater than 10% absenteeism on any day most likely due to ILI) which has increased considerably the total number of outbreaks reported compared to previous years.
ILI consultation rate
During week 6, the national ILI consultation rate was 11 consultations per 1,000 patient visits (see ILI graph) which was similar to the previous weeks and still significantly below the expected range for this time of the year. All provinces and territories had similar ILI consultation rates compared to their respective ILI rates in the previous week. Those under 20 years of age still had the highest consultation rates, with 64 and 13 per 1,000 patient visits among children under 5 years of age and among those 5 to 19 years of age, respectively.
Influenza-like illness (ILI) consultation rates, Canada, by report week,
2009-2010 compared to 1996/97 through to 2008/09 seasons


Note: No data available for mean rate in previous years for weeks 19 to 39 (1996-1997 through 2002-2003 seasons).
Delays in the reporting of data may cause data to change retrospectively.
Paediatric and Adult Influenza Hospitalizations and Deaths
In week 6, no laboratory-confirmed influenza-associated paediatric (under 17 years of age) hospitalizations were reported through the Immunization Monitoring Program Active (IMPACT) network. 1325* hospitalizations have been reported since week 17 (April 26): 97.0% of these hospitalizations were due to pandemic H1N1 2009. Since the beginning of the pandemic, eleven paediatric deaths due to pandemic H1N1 2009 were reported through the IMPACT network among children 16 years of age or under.
*Delays in the reporting of data may cause data to change restrospectively.
During week 6, no report was received from the Canadian Nosocomial Infection Surveillance Program (CNISP) on influenza-associated adult (16 years of age or older) hospitalizations and deaths. Since week 47 (November 22, 2009), 55 hospitalizations and 8 deaths have been reported through CNISP among adults 16 years of age or older. All of these hospitalizations and deaths were due to pandemic H1N1 2009. From June 1, 2009 to February 19, 2010, of the 552 laboratory-confirmed influenza cases among hospitalized adults reported through 27 of CNISP sentinel sites, 70% were pandemic H1N1 2009 cases. For these pandemic H1N1 2009 cases, most were among women (51%), 1.4% presented with influenza-associated bacteremia, 27% were admitted to the ICU, and 5% died (90% of whom had at least one underlying medical condition).
Please note the total number of CNISP reporting sites fluctuates weekly.
Laboratory Surveillance Summary
The proportion of tests that were positive for influenza A was 0.24% during week 6 which remained at a very low level (see Tests table). All provinces had a similar or lower proportion of positive tests for influenza compared to the previous week. During week 6, a total of 6 specimens tested positive for influenza (all A) and 3/4 (75%) of the positive influenza A subtyped specimens were pandemic H1N1 2009. Note that QC reported 44 positive specimens for A/H3N2 and 8 specimens for influenza B and ON reported 6 specimens for influenza B since August 30, 2009. The proportion of specimens positive for respiratory syncytial virus increased to 27.0% during week 6. Positive specimens were reported from all provinces except NB (data not shown). Also, the proportion of positive parainfluenza and adenovirus tests were higher than the proportion of positive tests for influenza.

Influenza tests reported and percentage of tests positive, Canada,
by report week, 2009-2010



Percent positive influenza tests, compared to other respiratory viruses, Canada,
by reporting week, 2009-2010


Weekly & Cumulative numbers of positive influenza specimens, by Provincial Laboratories
<TABLE class=widthFull cellSpacing=0 cellPadding=2 border=1><TFOOT><TR><TD class=fontSize85 colSpan=13>Note: Cumulative data includes updates to previous weeks; due to reporting delays, the sum of weekly report totals do not add up to cumulative totals.
* Not subtyped
</TD></TR></TFOOT><TBODY><TR class=alignCenter><TH class=bg-colour-blue scope=col rowSpan=3>Reporting provinces</TH><TH class="bg-colour-blue fontSize85" scope=colgroup colSpan=6>Weekly (February 7 to February 13, 2010)</TH><TH class="bg-colour-blue fontSize85" scope=colgroup colSpan=6>Cumulative (August 30, 2009 to February 13, 2010)</TH></TR><TR class=alignCenter><TH class="bg-colour-blue fontSize85" scope=colgroup colSpan=5>Influenza A</TH><TH class="bg-colour-blue fontSize85" scope=col>B</TH><TH class="bg-colour-blue fontSize85" scope=colgroup colSpan=5>Influenza A</TH><TH class=bg-colour-blue scope=col>B</TH></TR><TR class=alignCenter><TH class="fontSize85 bg-colour-blue" scope=col>A Total</TH><TH class="fontSize85 bg-colour-blue" scope=col>A(H1)</TH><TH class="fontSize85 bg-colour-blue" scope=col>A(H3)</TH><TH class="fontSize85 bg-colour-blue" scope=col>Pand H1N1</TH><TH class="fontSize85 bg-colour-blue" scope=col>A
(NS)*
</TH><TH class="fontSize85 bg-colour-blue" scope=col>Total</TH><TH class="fontSize85 bg-colour-blue" scope=col>A Total</TH><TH class="fontSize85 bg-colour-blue" scope=col>A(H1)</TH><TH class="fontSize85 bg-colour-blue" scope=col>A(H3)</TH><TH class="fontSize85 bg-colour-blue" scope=col>Pand H1N1</TH><TH class="fontSize85 bg-colour-blue" scope=col>A
(NS)*
</TH><TH class="fontSize85 bg-colour-blue" scope=col>Total</TH></TR><TR><TH class=bg-colour-blue scope=row>BC</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>6370</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD><TD class=alignCenter>5804</TD><TD class=alignCenter>565</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>AB</TH><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD><TD class=alignCenter>5867</TD><TD class=alignCenter>2</TD><TD class=alignCenter>5</TD><TD class=alignCenter>5759</TD><TD class=alignCenter>101</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>SK</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>2598</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD><TD class=alignCenter>2298</TD><TD class=alignCenter>299</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>MB</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1915</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1788</TD><TD class=alignCenter>127</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>ON</TH><TD class=alignCenter>4</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD><TD class=alignCenter>2</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD><TD class=alignCenter>7906</TD><TD class=alignCenter>3</TD><TD class=alignCenter>0</TD><TD class=alignCenter>3552</TD><TD class=alignCenter>4351</TD><TD class=alignCenter>6</TD></TR><TR><TH class=bg-colour-blue scope=row>QC</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>10689</TD><TD class=alignCenter>1</TD><TD class=alignCenter>44</TD><TD class=alignCenter>10644</TD><TD class=alignCenter>0</TD><TD class=alignCenter>8</TD></TR><TR><TH class=bg-colour-blue scope=row>NB</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1856</TD><TD class=alignCenter>1</TD><TD class=alignCenter>1</TD><TD class=alignCenter>1835</TD><TD class=alignCenter>19</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>NS</TH><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>786</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>753</TD><TD class=alignCenter>33</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>PE</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>97</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>96</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>NL</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>951</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>951</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>Canada</TH><TD class=alignCenter>6</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD><TD class=alignCenter>3</TD><TD class=alignCenter>2</TD><TD class=alignCenter>0</TD><TD class=alignCenter>39035</TD><TD class=alignCenter>7</TD><TD class=alignCenter>52</TD><TD class=alignCenter>33480</TD><TD class=alignCenter>5496</TD><TD class=alignCenter>14</TD></TR><TR><TD class=alignCenter scope=row colSpan=13>Specimens from NT, YT, and NU are sent to reference laboratories in other provinces </TD></TR></TBODY></TABLE>
Sale of antivirals (AV) in Canada
Nationally, antiviral prescriptions appear to be at the levels seen prior to the second wave. During week 6, antiviral prescription monitoring demonstrated a levelling-off in antiviral prescriptions in most provinces and territories. An analysis of antiviral data at the Health Region level demonstrated low antiviral prescription rates among the vast majority of Health Regions for the week of February 7 to February 13, 2010. None of the Health Regions reported an antiviral rate greater than 2.5 antivirals/1000 other prescriptions.

Reference: H1N1 Antiviral and OTC Surveillance Weekly Report. CFEZID, PHAC.
Canadian situation
Antigenic Characterization
Since September 1, 2009, the National Microbiology Laboratory (NML) has antigenically characterized 790 pandemic H1N1 2009 viruses and 10 seasonal influenza viruses (2 influenza A/H1N1, 7 H3N2, and 1 B virus) that were received from Canadian laboratories. Of the 790 pandemic H1N1 2009 viruses characterized, 786 (99.5%) were antigenically related to A/California/7/2009, which is the pandemic reference virus selected by WHO for the pandemic H1N1 2009 vaccine. Four viruses (0.5%) tested showed reduced titer with antisera produced against A/California/7/09. Of the seven seasonal influenza A (H3N2) viruses characterized, one was related to A/Brisbane/10/07, which is the influenza A/H3N2 component recommended for the 2009-10 influenza vaccine and six viruses were antigenically related to A/Perth/16/09, which is the WHO recommended influenza A (H3N2) component for the 2010 Southern Hemisphere vaccine.
Antiviral Resistance
NML: Pandemic H1N1 2009 viruses tested so far have been sensitive to zanamivir (981 samples) but resistant to amantadine (1051 samples).
NML/Provinces: Thirteen cases of oseltamivir resistant pandemic H1N1 2009 were reported to date in Canada: one in British Columbia, four in Alberta, one in Manitoba, four in Ontario, two in Quebec, and one in New Brunswick. The 13 resistant cases were associated with oseltamivir treatment/prophylaxis.
International update
Global information
WHO: Worldwide more than 212 countries and overseas territories or communities reported laboratory confirmed cases of pandemic H1N1 2009, including at least 15,292 deaths as of February 7, 2010. In the temperate zone of the Northern hemisphere, overall pandemic influenza activity continued to decline in most countries. The most active areas of transmission continue to be in later peaking areas, particularly Northern Africa, South Asia, and East Asia. In Europe, although pandemic influenza virus continues to circulate widely, particularly across central, southern, and eastern Europe, the overall intensity of pandemic influenza activity has declined substantially from peaks of activity seen earlier during the winter transmission period. In temperate regions of the southern hemisphere, sporadic cases of pandemic H1N1 2009 continued to be reported without evidence of sustained community transmission. Pandemic H1N1 2009 virus continued to be the predominant virus circulating worldwide. In addition to the increasing proportion of seasonal influenza type B viruses recently detected in China, low levels of seasonal H3N2 and type B viruses are circulating in parts of Africa, East and Southeast Asia and are being detected only sporadically in other continents.
<
http://www.who.int/csr/don/2010_02_12/en/index.html> and
<
http://www.who.int/csr/disease/swineflu/laboratory12_02_2010/en/index.html>
Antiviral resistance: To date, 245 pandemic H1N1 2009 isolates worldwide have been found to be resistant to oseltamivir, all with the same H275Y mutation and all remain sensitive to zanamivir.
<
http://www.who.int/csr/disease/swineflu/laboratory12_02_2010/en/index.html>
Geographic update
United States: During week 5 (January 31-February 6, 2010), influenza activity remained at approximately the same levels as last week in the United States. 4.8% of the specimens tested this week were positive for influenza. While no states reported widespread influenza activity, 6 states reported regional influenza activity, Puerto Rico and 11 states reported local activity and the majority of the states reported sporadic influenza activity. The proportion of outpatient visits for influenza-like illness (ILI) was 2.1% which was below the national baseline of 2.3%. Three of 10 regions reported ILI above region-specific baseline levels. The proportion of deaths attributed to pneumonia and influenza decreased slightly over the previous week and remained below the epidemic threshold for this time of the year. Three influenza-associated pediatric deaths were reported during week 5: two deaths were associated with pandemic H1N1 2009 virus infection and one was associated with influenza A virus for which the subtype was undetermined. Of the subtyped influenza A viruses reported to CDC, 100% were pandemic H1N1 2009 viruses.
<
http://www.cdc.gov/flu/weekly/>
Europe: In Europe for week 5/2010 (February 1-7, 2010), the pandemic H1N1 2009 was well past its peak. In eight countries (Austria, Bulgaria, Czech Republic, Germany, Greece, Italy, Malta, Slovakia), local or regional transmission of the pandemic virus continues at low to medium intensity. Elsewhere intensity was low, but sporadic transmission of the pandemic virus was reported in the majority of countries. For the majority of countries that reported age-specific incidence of ILI, the most affected age group was 0?14. The number of reported SARI (severe acute respiratory illness) cases continued to decline. Of the 62 SARI cases reported this week, 30 (48%) were known to have required ICU admission and 16 (24%) needed ventilator support. Of the 39 SARI cases for whom underlying conditions were reported, 9 (23%) had no known underlying condition. Asthma and other chronic lung diseases alone or associated with other conditions were reported in 12 (31%) cases. Of the 910 specimens collected by sentinel physicians, 76 (8.4%) were positive for influenza virus, mainly the pandemic virus; this is consistent with a declining trend. Since their peak in week 01/2010, the total number of respiratory syncytial virus (RSV) detections in 11 countries has been decreasing. However in Austria, Denmark, Estonia, Germany, Latvia and Sweden, the number of RSV positive samples has increased for at least two consecutive weeks. In contrast to the pandemic virus there is currently no evidence of virus circulation due to other influenza A viruses this week, but there is some circulation of influenza B viruses.
<
http://ecdc.europa.eu/en/publications/Publications/100212_EISN_Weekly_Influenza_Surveillance_Overview .pdf>
Asia: In South and Southeast Asia, pandemic influenza virus continues to circulate widely across the region, however, overall activity continues to decrease or remain low in most places. In India, influenza activity continued to decline in all regions of the country, however, the most active areas of transmission are currently in the western states. In Thailand, overall activity remains low, although focal areas of increased ILI activity were reported in central and northern Thailand. In East Asia, pandemic influenza transmission remains geographically widespread across the region, however, overall activity continued to decline. In China, pandemic and seasonal influenza viruses continue to co-circulate, however, over the last several weeks, seasonal influenza type B viruses have been predominant. In Japan, influenza activity continues to decrease towards seasonal baselines, including in Okinawa which is experiencing greater levels of influenza activity than other parts of the country. In Republic of Korea (S. Korea), levels of ILI have decreased substantially to near baseline levels. In addition to the increasing proportion of seasonal influenza type B viruses recently detected in China, low levels of seasonal H3N2 and type B viruses are circulating in parts of East and Southeast Asia.
<
http://www.who.int/csr/don/2010_02_12/en/index.html>
Real-time weekly and cumulative numbers of deaths due to pandemic H1N1 2009, by province/territory, Canada, as of February 18, 2010, 12h00 EDT
<TABLE class="width75 alignCenter" cellSpacing=0 cellPadding=1 border=1><TBODY><TR class=bg-colour-blue><TH scope=col>Province/ Territory</TH><TH scope=col>New Deaths
(from February 11 to 18, 2010 12h00 EDT)
</TH><TH scope=col>Cumulative deaths</TH></TR><TR><TD class=alignCenter>BC</TD><TD class=alignCenter>1</TD><TD class=alignCenter>56</TD></TR><TR><TD class=alignCenter>AB</TD><TD class=alignCenter>0</TD><TD class=alignCenter>71</TD></TR><TR><TD class=alignCenter>SK</TD><TD class=alignCenter>0</TD><TD class=alignCenter>15</TD></TR><TR><TD class=alignCenter>MB</TD><TD class=alignCenter>0</TD><TD class=alignCenter>11</TD></TR><TR><TD class=alignCenter>ON</TD><TD class=alignCenter>0</TD><TD class=alignCenter>128</TD></TR><TR><TD class=alignCenter>QC</TD><TD class=alignCenter>0</TD><TD class=alignCenter>108</TD></TR><TR><TD class=alignCenter>NB</TD><TD class=alignCenter>0</TD><TD class=alignCenter>8</TD></TR><TR><TD class=alignCenter>NS</TD><TD class=alignCenter>0</TD><TD class=alignCenter>7</TD></TR><TR><TD class=alignCenter>PE</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD></TR><TR><TD class=alignCenter>NL</TD><TD class=alignCenter>0</TD><TD class=alignCenter>18</TD></TR><TR><TD class=alignCenter>YT</TD><TD class=alignCenter>0</TD><TD class=alignCenter>3</TD></TR><TR><TD class=alignCenter>NT</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD></TR><TR><TD class=alignCenter>NU</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD></TR><TR><TD class=alignCenter>Canada</TD><TD class=alignCenter>1</TD><TD class=alignCenter>427</TD></TR></TBODY></TABLE>
February 7 to February 13, 2010 (Week 6)
Posted 2010-02-19
Weekly and cumulative numbers of hospitalized cases, ICU admissions and deaths among Pandemic H1N1 2009 confirmed cases, Canada, to February 13, 2010<SUP>?</SUP>
<TABLE class="widthFull fontSize85" cellSpacing=0 cellPadding=2 border=1><TFOOT><TR><TD colSpan=10><SUP id=star>*</SUP>Based on reporting date.
<SUP id=dstar>**</SUP>Based on epidemiological date, hospitalization date, death date and reporting date.
<SUP>1</SUP> Aggregate counts were reported this week.
? Note that due to reporting delays, some PTs reported retrospectively on first and second wave cases.
</TD></TR></TFOOT><TBODY><TR class=alignCenter><TH class=bg-colour-blue scope=col rowSpan=2>Province/
Territory
</TH><TH class=bg-colour-blue scope=colgroup colSpan=3>Week 6
(February 7 to February 13, 2010)*
</TH><TH class=bg-colour-blue scope=colgroup colSpan=3>From August 30, 2009 to
February 13, 2010**
</TH><TH class=bg-colour-blue scope=colgroup colSpan=3>From April 12 to August 29, 2009**</TH></TR><TR class=alignCenter><TH class=bg-colour-blue scope=col>Hospitalized cases</TH><TH class=bg-colour-blue scope=col>ICU admissions</TH><TH class=bg-colour-blue scope=col>Deaths</TH><TH class=bg-colour-blue scope=col>Hospitalized cases</TH><TH class=bg-colour-blue scope=col>ICU admissions</TH><TH class=bg-colour-blue scope=col>Deaths</TH><TH class=bg-colour-blue scope=col>Hospitalized cases</TH><TH class=bg-colour-blue scope=col>ICU admissions</TH><TH class=bg-colour-blue scope=col>Deaths</TH></TR><TR><TH class=bg-colour-blue scope=row>BC<SUP>1,?</SUP></TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD><TD class=alignCenter>1009</TD><TD class=alignCenter>135</TD><TD class=alignCenter>50</TD><TD class=alignCenter>49</TD><TD class=alignCenter>19</TD><TD class=alignCenter>6</TD></TR><TR><TH class=bg-colour-blue scope=row>AB</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1147</TD><TD class=alignCenter>210</TD><TD class=alignCenter>64</TD><TD class=alignCenter>129</TD><TD class=alignCenter>29</TD><TD class=alignCenter>7</TD></TR><TR><TH class=bg-colour-blue scope=row>SK</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>44</TD><TD class=alignCenter>40</TD><TD class=alignCenter>11</TD><TD class=alignCenter>23</TD><TD class=alignCenter>12</TD><TD class=alignCenter>4</TD></TR><TR><TH class=bg-colour-blue scope=row>MB</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>166</TD><TD class=alignCenter>18</TD><TD class=alignCenter>4</TD><TD class=alignCenter>213</TD><TD class=alignCenter>43</TD><TD class=alignCenter>7</TD></TR><TR><TH class=bg-colour-blue scope=row>ON</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1444</TD><TD class=alignCenter>248</TD><TD class=alignCenter>103</TD><TD class=alignCenter>399</TD><TD class=alignCenter>69</TD><TD class=alignCenter>25</TD></TR><TR><TH class=bg-colour-blue scope=row>QC</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>2490</TD><TD class=alignCenter>361</TD><TD class=alignCenter>81</TD><TD class=alignCenter>572</TD><TD class=alignCenter>104</TD><TD class=alignCenter>27</TD></TR><TR><TH class=bg-colour-blue scope=row>NB<SUP>1</SUP></TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>161</TD><TD class=alignCenter>33</TD><TD class=alignCenter>8</TD><TD class=alignCenter>2</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>NS</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>276</TD><TD class=alignCenter>42</TD><TD class=alignCenter>6</TD><TD class=alignCenter>17</TD><TD class=alignCenter>8</TD><TD class=alignCenter>1</TD></TR><TR><TH class=bg-colour-blue scope=row>PE</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>49</TD><TD class=alignCenter>9</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>NL</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>274</TD><TD class=alignCenter>51</TD><TD class=alignCenter>18</TD><TD class=alignCenter>3</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>YT</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>15</TD><TD class=alignCenter>3</TD><TD class=alignCenter>3</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>NT</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>46</TD><TD class=alignCenter>7</TD><TD class=alignCenter>1</TD><TD class=alignCenter>6</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>NU</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>6</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>74</TD><TD class=alignCenter>6</TD><TD class=alignCenter>1</TD></TR><TR><TH class=bg-colour-blue scope=row>Canada</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD><TD class=alignCenter>7127</TD><TD class=alignCenter>1157</TD><TD class=alignCenter>349</TD><TD class=alignCenter>1488</TD><TD class=alignCenter>292</TD><TD class=alignCenter>78</TD></TR></TBODY></TABLE>
Descriptive characteristics of laboratory-confirmed Canadian pandemic H1N1 2009 hospitalized cases, ICU-admitted cases and deaths with core information available, reported to PHAC as of February 13, 2010<SUP><SUP>?</SUP> </SUP>
<TABLE class=fontSize85 cellSpacing=0 cellPadding=2 border=1><TBODY><TR class=alignCenter><TD rowSpan=2></TD><TH class=bg-colour-blue colSpan=3>From April 12 to August 29, 2009</TH><TH class=bg-colour-blue colSpan=3>From August 30, 2009 to February 13, 2010</TH><TH class=bg-colour-blue colSpan=3>Cumulative: From
April 12, 2009 to February 13, 2010
</TH></TR><TR class=alignCenter><TH class=bg-colour-blue>Hospitalized cases (n=1488)</TH><TH class=bg-colour-blue>ICU-admitted
(n=292)
</TH><TH class=bg-colour-blue>Deaths
(n=78)
</TH><TH class=bg-colour-blue>Hospitalized
cases (n=6674)
</TH><TH class=bg-colour-blue>ICU-admitted
(n=1157)
</TH><TH class=bg-colour-blue>Deaths
(n=345)
</TH><TH class=bg-colour-blue>Hospitalized
cases
(n=8162)
</TH><TH class=bg-colour-blue>ICU-admitted
(n=1449)
</TH><TH class=bg-colour-blue>Deaths
(n=423)
</TH></TR><TR><TH class="bg-colour-blue alignLeft">Females, %</TH><TD class=alignCenter>51.3</TD><TD class=alignCenter>57.2</TD><TD class=alignCenter>62.8</TD><TD class=alignCenter>49.7</TD><TD class=alignCenter>49.7</TD><TD class=alignCenter>46.7</TD><TD class=alignCenter>50.0</TD><TD class=alignCenter>51.2</TD><TD class=alignCenter>49.6</TD></TR><TR><TH class="bg-colour-blue alignLeft">Median age</TH><TD class=alignCenter>23.0</TD><TD class=alignCenter>37.0</TD><TD class=alignCenter>51.0</TD><TD class=alignCenter>30.0</TD><TD class=alignCenter>47.0</TD><TD class=alignCenter>54.0</TD><TD class=alignCenter>29.0</TD><TD class=alignCenter>46.0</TD><TD class=alignCenter>53.0</TD></TR><TR><TH class="bg-colour-blue alignLeft">Aboriginal status<SUP>1</SUP>, % </TH><TD class=alignCenter>20.0-27.7</TD><TD class=alignCenter>16.1-21.9</TD><TD class=alignCenter>11.5-17.3</TD><TD class=alignCenter>4.6-6.1</TD><TD class=alignCenter>5.9-7.8</TD><TD class=alignCenter>6.1-8.9</TD><TD class=alignCenter>7.4-10.0</TD><TD class=alignCenter>7.9-10.6</TD><TD class=alignCenter>7.1-10.4</TD></TR><TR><TH class="bg-colour-blue alignLeft">Underlying medical
conditions<SUP>2</SUP>, %
</TH><TD class=alignCenter>47.5
(652/1373)
</TD><TD class=alignCenter>60.2
(162/269)
</TD><TD class=alignCenter>73.3
(55/75)
</TD><TD class=alignCenter>58.4
(1884/3226)
</TD><TD class=alignCenter>72.9
(655/899)
</TD><TD class=alignCenter>84.2
(240/285)
</TD><TD class=alignCenter>55.1
(2536/4599)
</TD><TD class=alignCenter>69.9
(817/1168)
</TD><TD class=alignCenter>81.9
(295/360)
</TD></TR><TR><TH class="bg-colour-blue alignLeft">Pregnancy<SUP>3</SUP>, %</TH><TD class=alignCenter>27.6
(75/272)
</TD><TD class=alignCenter>19.7
(15/76)
</TD><TD class=alignCenter>28.6
(4/14)
</TD><TD class=alignCenter>18.5
(188/1018)
</TD><TD class=alignCenter>8.4
(15/178)
</TD><TD class=alignCenter>0.0
(0/36)
</TD><TD class=alignCenter>20.4
(263/1290)
</TD><TD class=alignCenter>11.8
(30/254)
</TD><TD class=alignCenter>8.0
(4/50)
</TD></TR><TR><TD colSpan=10><SUP>1 </SUP>ince Aboriginal status is not reported by two provinces (which comprise 23% of the Aboriginal population) two methods were used to calculate proportions: one proportion was calculated by including ON and NS cases in the denominator (which is an underestimate of the true proportion); while the other proportion was calculated by excluding ON and NS cases in the denominator (which is an overestimate).
<SUP>2 </SUP>Proportion of cases with at least one underlying medical condition (excluding pregnancy) among those for whom the information was available. Please note that results may differ slightly compared to the previous weeks due to updates in the national database.
<SUP>3 </SUP>Percent of pregnant women among women 15 to 44 years of age.
? All cases admitted to ICU are included in the hospitalization count; however, not all the fatal cases have been hospitalized before dying.
</TD></TR></TBODY></TABLE>
Overall Influenza Summary - Week 6 (February 7 to February 13, 2010)
During week 6, all influenza indicators continued to decline compared to the previous week and were still considerably under the expected level for this time of the year. Only 0.24% of the specimens tested were positive for influenza A. Three out of four (75%) of the positive influenza A subtyped specimens were pandemic H1N1 2009 this week.
In week 6, nineteen regions in BC, AB, MB, ON, QC, NS & NU reported sporadic activity, while thirty-five regions reported no activity in BC, AB, SK, MB, ON, QC, NB, PE, NS, NL, YT & NT. The 5 influenza outbreaks reported this week were all in schools (NS).

<TABLE class=widthFull cellSpacing=0 cellPadding=0><TBODY><TR class=alignCenter><TD colSpan=2>Map of overall Influenza activity level by provinces and territories, Week 6, Canada
</TD></TR><TR class=alignCenter><TD>

</TD><TD><TABLE cellSpacing=0 cellPadding=1 border=0><TBODY><TR><TD align=middle><TABLE class=border-lite cellSpacing=1 cellPadding=1><TBODY><TR align=middle><TD>No Data </TD><TD>
</TD></TR><TR class=alignCenter><TD>No Activity</TD><TD>
</TD></TR><TR class=alignCenter><TD>Sporadic Activity</TD><TD>
</TD></TR><TR align=middle><TD>Localized Activity</TD><TD>
</TD></TR><TR align=middle><TD>WidespreadActivity
</TD><TD>
</TD></TR></TBODY></TABLE></TD></TR></TBODY></TABLE></TD></TR><TR><TD class=fontSize85 colSpan=2>Note: Influenza activity levels, as represented on this map, are assigned and reported by Provincial and Territorial Ministries of Health, based on laboratory confirmations, sentinel ILI rates (see graphs and tables) and reported outbreaks. Please refer to detailed definitions on the last page. For areas where no data is reported, late reports from these provinces and territories will appear on the FluWatch website. </TD></TR></TBODY></TABLE>
Number of influenza surveillance regions<SUP>?</SUP> reporting widespread or localized influenza activity,
Canada, by report week, 2009-2010 (N=54)


? sub-regions within the province or territory as defined by the provincial/territorial epidemiologist. Graph may change as late returns come in.

Overall Number of Influenza Outbreaks, Canada, by Report Week, 2009-2010


Note that this was the first year that all the provinces and territories were reporting on influenza outbreaks in schools (greater than 10% absenteeism on any day most likely due to ILI) which has increased considerably the total number of outbreaks reported compared to previous years.
ILI consultation rate
During week 6, the national ILI consultation rate was 11 consultations per 1,000 patient visits (see ILI graph) which was similar to the previous weeks and still significantly below the expected range for this time of the year. All provinces and territories had similar ILI consultation rates compared to their respective ILI rates in the previous week. Those under 20 years of age still had the highest consultation rates, with 64 and 13 per 1,000 patient visits among children under 5 years of age and among those 5 to 19 years of age, respectively.
Influenza-like illness (ILI) consultation rates, Canada, by report week,
2009-2010 compared to 1996/97 through to 2008/09 seasons


Note: No data available for mean rate in previous years for weeks 19 to 39 (1996-1997 through 2002-2003 seasons).
Delays in the reporting of data may cause data to change retrospectively.
Paediatric and Adult Influenza Hospitalizations and Deaths
In week 6, no laboratory-confirmed influenza-associated paediatric (under 17 years of age) hospitalizations were reported through the Immunization Monitoring Program Active (IMPACT) network. 1325* hospitalizations have been reported since week 17 (April 26): 97.0% of these hospitalizations were due to pandemic H1N1 2009. Since the beginning of the pandemic, eleven paediatric deaths due to pandemic H1N1 2009 were reported through the IMPACT network among children 16 years of age or under.
*Delays in the reporting of data may cause data to change restrospectively.
During week 6, no report was received from the Canadian Nosocomial Infection Surveillance Program (CNISP) on influenza-associated adult (16 years of age or older) hospitalizations and deaths. Since week 47 (November 22, 2009), 55 hospitalizations and 8 deaths have been reported through CNISP among adults 16 years of age or older. All of these hospitalizations and deaths were due to pandemic H1N1 2009. From June 1, 2009 to February 19, 2010, of the 552 laboratory-confirmed influenza cases among hospitalized adults reported through 27 of CNISP sentinel sites, 70% were pandemic H1N1 2009 cases. For these pandemic H1N1 2009 cases, most were among women (51%), 1.4% presented with influenza-associated bacteremia, 27% were admitted to the ICU, and 5% died (90% of whom had at least one underlying medical condition).
Please note the total number of CNISP reporting sites fluctuates weekly.
Laboratory Surveillance Summary
The proportion of tests that were positive for influenza A was 0.24% during week 6 which remained at a very low level (see Tests table). All provinces had a similar or lower proportion of positive tests for influenza compared to the previous week. During week 6, a total of 6 specimens tested positive for influenza (all A) and 3/4 (75%) of the positive influenza A subtyped specimens were pandemic H1N1 2009. Note that QC reported 44 positive specimens for A/H3N2 and 8 specimens for influenza B and ON reported 6 specimens for influenza B since August 30, 2009. The proportion of specimens positive for respiratory syncytial virus increased to 27.0% during week 6. Positive specimens were reported from all provinces except NB (data not shown). Also, the proportion of positive parainfluenza and adenovirus tests were higher than the proportion of positive tests for influenza.

Influenza tests reported and percentage of tests positive, Canada,
by report week, 2009-2010



Percent positive influenza tests, compared to other respiratory viruses, Canada,
by reporting week, 2009-2010


Weekly & Cumulative numbers of positive influenza specimens, by Provincial Laboratories
<TABLE class=widthFull cellSpacing=0 cellPadding=2 border=1><TFOOT><TR><TD class=fontSize85 colSpan=13>Note: Cumulative data includes updates to previous weeks; due to reporting delays, the sum of weekly report totals do not add up to cumulative totals.
* Not subtyped
</TD></TR></TFOOT><TBODY><TR class=alignCenter><TH class=bg-colour-blue scope=col rowSpan=3>Reporting provinces</TH><TH class="bg-colour-blue fontSize85" scope=colgroup colSpan=6>Weekly (February 7 to February 13, 2010)</TH><TH class="bg-colour-blue fontSize85" scope=colgroup colSpan=6>Cumulative (August 30, 2009 to February 13, 2010)</TH></TR><TR class=alignCenter><TH class="bg-colour-blue fontSize85" scope=colgroup colSpan=5>Influenza A</TH><TH class="bg-colour-blue fontSize85" scope=col>B</TH><TH class="bg-colour-blue fontSize85" scope=colgroup colSpan=5>Influenza A</TH><TH class=bg-colour-blue scope=col>B</TH></TR><TR class=alignCenter><TH class="fontSize85 bg-colour-blue" scope=col>A Total</TH><TH class="fontSize85 bg-colour-blue" scope=col>A(H1)</TH><TH class="fontSize85 bg-colour-blue" scope=col>A(H3)</TH><TH class="fontSize85 bg-colour-blue" scope=col>Pand H1N1</TH><TH class="fontSize85 bg-colour-blue" scope=col>A
(NS)*
</TH><TH class="fontSize85 bg-colour-blue" scope=col>Total</TH><TH class="fontSize85 bg-colour-blue" scope=col>A Total</TH><TH class="fontSize85 bg-colour-blue" scope=col>A(H1)</TH><TH class="fontSize85 bg-colour-blue" scope=col>A(H3)</TH><TH class="fontSize85 bg-colour-blue" scope=col>Pand H1N1</TH><TH class="fontSize85 bg-colour-blue" scope=col>A
(NS)*
</TH><TH class="fontSize85 bg-colour-blue" scope=col>Total</TH></TR><TR><TH class=bg-colour-blue scope=row>BC</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>6370</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD><TD class=alignCenter>5804</TD><TD class=alignCenter>565</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>AB</TH><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD><TD class=alignCenter>5867</TD><TD class=alignCenter>2</TD><TD class=alignCenter>5</TD><TD class=alignCenter>5759</TD><TD class=alignCenter>101</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>SK</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>2598</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD><TD class=alignCenter>2298</TD><TD class=alignCenter>299</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>MB</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1915</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1788</TD><TD class=alignCenter>127</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>ON</TH><TD class=alignCenter>4</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD><TD class=alignCenter>2</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD><TD class=alignCenter>7906</TD><TD class=alignCenter>3</TD><TD class=alignCenter>0</TD><TD class=alignCenter>3552</TD><TD class=alignCenter>4351</TD><TD class=alignCenter>6</TD></TR><TR><TH class=bg-colour-blue scope=row>QC</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>10689</TD><TD class=alignCenter>1</TD><TD class=alignCenter>44</TD><TD class=alignCenter>10644</TD><TD class=alignCenter>0</TD><TD class=alignCenter>8</TD></TR><TR><TH class=bg-colour-blue scope=row>NB</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1856</TD><TD class=alignCenter>1</TD><TD class=alignCenter>1</TD><TD class=alignCenter>1835</TD><TD class=alignCenter>19</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>NS</TH><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>786</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>753</TD><TD class=alignCenter>33</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>PE</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>97</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>96</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>NL</TH><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>951</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD><TD class=alignCenter>951</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD></TR><TR><TH class=bg-colour-blue scope=row>Canada</TH><TD class=alignCenter>6</TD><TD class=alignCenter>1</TD><TD class=alignCenter>0</TD><TD class=alignCenter>3</TD><TD class=alignCenter>2</TD><TD class=alignCenter>0</TD><TD class=alignCenter>39035</TD><TD class=alignCenter>7</TD><TD class=alignCenter>52</TD><TD class=alignCenter>33480</TD><TD class=alignCenter>5496</TD><TD class=alignCenter>14</TD></TR><TR><TD class=alignCenter scope=row colSpan=13>Specimens from NT, YT, and NU are sent to reference laboratories in other provinces </TD></TR></TBODY></TABLE>
Sale of antivirals (AV) in Canada
Nationally, antiviral prescriptions appear to be at the levels seen prior to the second wave. During week 6, antiviral prescription monitoring demonstrated a levelling-off in antiviral prescriptions in most provinces and territories. An analysis of antiviral data at the Health Region level demonstrated low antiviral prescription rates among the vast majority of Health Regions for the week of February 7 to February 13, 2010. None of the Health Regions reported an antiviral rate greater than 2.5 antivirals/1000 other prescriptions.

Reference: H1N1 Antiviral and OTC Surveillance Weekly Report. CFEZID, PHAC.
Canadian situation
Antigenic Characterization
Since September 1, 2009, the National Microbiology Laboratory (NML) has antigenically characterized 790 pandemic H1N1 2009 viruses and 10 seasonal influenza viruses (2 influenza A/H1N1, 7 H3N2, and 1 B virus) that were received from Canadian laboratories. Of the 790 pandemic H1N1 2009 viruses characterized, 786 (99.5%) were antigenically related to A/California/7/2009, which is the pandemic reference virus selected by WHO for the pandemic H1N1 2009 vaccine. Four viruses (0.5%) tested showed reduced titer with antisera produced against A/California/7/09. Of the seven seasonal influenza A (H3N2) viruses characterized, one was related to A/Brisbane/10/07, which is the influenza A/H3N2 component recommended for the 2009-10 influenza vaccine and six viruses were antigenically related to A/Perth/16/09, which is the WHO recommended influenza A (H3N2) component for the 2010 Southern Hemisphere vaccine.
Antiviral Resistance
NML: Pandemic H1N1 2009 viruses tested so far have been sensitive to zanamivir (981 samples) but resistant to amantadine (1051 samples).
NML/Provinces: Thirteen cases of oseltamivir resistant pandemic H1N1 2009 were reported to date in Canada: one in British Columbia, four in Alberta, one in Manitoba, four in Ontario, two in Quebec, and one in New Brunswick. The 13 resistant cases were associated with oseltamivir treatment/prophylaxis.
International update
Global information
WHO: Worldwide more than 212 countries and overseas territories or communities reported laboratory confirmed cases of pandemic H1N1 2009, including at least 15,292 deaths as of February 7, 2010. In the temperate zone of the Northern hemisphere, overall pandemic influenza activity continued to decline in most countries. The most active areas of transmission continue to be in later peaking areas, particularly Northern Africa, South Asia, and East Asia. In Europe, although pandemic influenza virus continues to circulate widely, particularly across central, southern, and eastern Europe, the overall intensity of pandemic influenza activity has declined substantially from peaks of activity seen earlier during the winter transmission period. In temperate regions of the southern hemisphere, sporadic cases of pandemic H1N1 2009 continued to be reported without evidence of sustained community transmission. Pandemic H1N1 2009 virus continued to be the predominant virus circulating worldwide. In addition to the increasing proportion of seasonal influenza type B viruses recently detected in China, low levels of seasonal H3N2 and type B viruses are circulating in parts of Africa, East and Southeast Asia and are being detected only sporadically in other continents.
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Antiviral resistance: To date, 245 pandemic H1N1 2009 isolates worldwide have been found to be resistant to oseltamivir, all with the same H275Y mutation and all remain sensitive to zanamivir.
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Geographic update
United States: During week 5 (January 31-February 6, 2010), influenza activity remained at approximately the same levels as last week in the United States. 4.8% of the specimens tested this week were positive for influenza. While no states reported widespread influenza activity, 6 states reported regional influenza activity, Puerto Rico and 11 states reported local activity and the majority of the states reported sporadic influenza activity. The proportion of outpatient visits for influenza-like illness (ILI) was 2.1% which was below the national baseline of 2.3%. Three of 10 regions reported ILI above region-specific baseline levels. The proportion of deaths attributed to pneumonia and influenza decreased slightly over the previous week and remained below the epidemic threshold for this time of the year. Three influenza-associated pediatric deaths were reported during week 5: two deaths were associated with pandemic H1N1 2009 virus infection and one was associated with influenza A virus for which the subtype was undetermined. Of the subtyped influenza A viruses reported to CDC, 100% were pandemic H1N1 2009 viruses.
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Europe: In Europe for week 5/2010 (February 1-7, 2010), the pandemic H1N1 2009 was well past its peak. In eight countries (Austria, Bulgaria, Czech Republic, Germany, Greece, Italy, Malta, Slovakia), local or regional transmission of the pandemic virus continues at low to medium intensity. Elsewhere intensity was low, but sporadic transmission of the pandemic virus was reported in the majority of countries. For the majority of countries that reported age-specific incidence of ILI, the most affected age group was 0?14. The number of reported SARI (severe acute respiratory illness) cases continued to decline. Of the 62 SARI cases reported this week, 30 (48%) were known to have required ICU admission and 16 (24%) needed ventilator support. Of the 39 SARI cases for whom underlying conditions were reported, 9 (23%) had no known underlying condition. Asthma and other chronic lung diseases alone or associated with other conditions were reported in 12 (31%) cases. Of the 910 specimens collected by sentinel physicians, 76 (8.4%) were positive for influenza virus, mainly the pandemic virus; this is consistent with a declining trend. Since their peak in week 01/2010, the total number of respiratory syncytial virus (RSV) detections in 11 countries has been decreasing. However in Austria, Denmark, Estonia, Germany, Latvia and Sweden, the number of RSV positive samples has increased for at least two consecutive weeks. In contrast to the pandemic virus there is currently no evidence of virus circulation due to other influenza A viruses this week, but there is some circulation of influenza B viruses.
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Asia: In South and Southeast Asia, pandemic influenza virus continues to circulate widely across the region, however, overall activity continues to decrease or remain low in most places. In India, influenza activity continued to decline in all regions of the country, however, the most active areas of transmission are currently in the western states. In Thailand, overall activity remains low, although focal areas of increased ILI activity were reported in central and northern Thailand. In East Asia, pandemic influenza transmission remains geographically widespread across the region, however, overall activity continued to decline. In China, pandemic and seasonal influenza viruses continue to co-circulate, however, over the last several weeks, seasonal influenza type B viruses have been predominant. In Japan, influenza activity continues to decrease towards seasonal baselines, including in Okinawa which is experiencing greater levels of influenza activity than other parts of the country. In Republic of Korea (S. Korea), levels of ILI have decreased substantially to near baseline levels. In addition to the increasing proportion of seasonal influenza type B viruses recently detected in China, low levels of seasonal H3N2 and type B viruses are circulating in parts of East and Southeast Asia.
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Real-time weekly and cumulative numbers of deaths due to pandemic H1N1 2009, by province/territory, Canada, as of February 18, 2010, 12h00 EDT
<TABLE class="width75 alignCenter" cellSpacing=0 cellPadding=1 border=1><TBODY><TR class=bg-colour-blue><TH scope=col>Province/ Territory</TH><TH scope=col>New Deaths
(from February 11 to 18, 2010 12h00 EDT)
</TH><TH scope=col>Cumulative deaths</TH></TR><TR><TD class=alignCenter>BC</TD><TD class=alignCenter>1</TD><TD class=alignCenter>56</TD></TR><TR><TD class=alignCenter>AB</TD><TD class=alignCenter>0</TD><TD class=alignCenter>71</TD></TR><TR><TD class=alignCenter>SK</TD><TD class=alignCenter>0</TD><TD class=alignCenter>15</TD></TR><TR><TD class=alignCenter>MB</TD><TD class=alignCenter>0</TD><TD class=alignCenter>11</TD></TR><TR><TD class=alignCenter>ON</TD><TD class=alignCenter>0</TD><TD class=alignCenter>128</TD></TR><TR><TD class=alignCenter>QC</TD><TD class=alignCenter>0</TD><TD class=alignCenter>108</TD></TR><TR><TD class=alignCenter>NB</TD><TD class=alignCenter>0</TD><TD class=alignCenter>8</TD></TR><TR><TD class=alignCenter>NS</TD><TD class=alignCenter>0</TD><TD class=alignCenter>7</TD></TR><TR><TD class=alignCenter>PE</TD><TD class=alignCenter>0</TD><TD class=alignCenter>0</TD></TR><TR><TD class=alignCenter>NL</TD><TD class=alignCenter>0</TD><TD class=alignCenter>18</TD></TR><TR><TD class=alignCenter>YT</TD><TD class=alignCenter>0</TD><TD class=alignCenter>3</TD></TR><TR><TD class=alignCenter>NT</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD></TR><TR><TD class=alignCenter>NU</TD><TD class=alignCenter>0</TD><TD class=alignCenter>1</TD></TR><TR><TD class=alignCenter>Canada</TD><TD class=alignCenter>1</TD><TD class=alignCenter>427</TD></TR></TBODY></TABLE>





























































































































































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