China - 2 family members died of pneumonia, 1 hospitalized in stable condition - Government denies SARS, H5N1, NCoV and H1N1pdm09 - Shanghai - March 7, 2013

[sharon sanders]

machine translation

Minhang currently unknown death "? Department of health departments to identify rumors
March 8, 2013 08:52
Source: LONDON author: white feather election is issued: intern Gu Yiqin
　　LONDON, March 8: i Times newspaper reported yesterday net transfer to Minhang now unexplained deaths, rumors verification department by the health department. 　　Microblogging yesterday said the sudden onset of Minhang District, "a family of four, just two days from discovery to respiratory failure, respiratory failure associated with circulatory failure death of two, in the end is so far not clear what kind of flu". 　　In response, the city health department verification microblogging preaching wrong. According to reports, the city and five hospitals from 14 to 24, has a family of three admitted due to fever, cough treatment, the hospital started in the early morning of the 26th plan reported Minhang District Center for Disease Control sampling and epidemiological investigation. After consultation, the three patients are pneumonia, inspection by the Shanghai Public Health Clinical Center, exclude SARS, bird flu, novel coronavirus and swine flu and other infectious diseases.

Experts believe that two people died (age 87,57 years old) suffering from a number of basic diseases, and lung of severe infections caused by. Another patient (69 years old) is still hospitalized in stable condition. Health care workers in close contact with the patient and family members had no disease.
　　
zhttp://sh.eastday.com/m/20130308/u1a7242430.html

[Gert van der Hoek]

Re: China - 2 family members died of pneumonia, 1 hospitalized in stable condition - Government denies SARS, H5N1, NCoV and H1N1pdm09 - Shanghai

SARS ruled out in death cases

By Cai Wenjun | 2013-3-8

HEALTH authorities have ruled out SARS, bird flu or a new SARS-like virus in the deaths of two people from the same family at Shanghai No. 5 People's Hospital.

The hospital said three members of the Li family had been admitted between February 14 and 24 for symptoms including a high fever and coughing.

All three, aged 55, 69 and 87, were diagnosed as having pneumonia.

Since they were from the same family, the hospital reported the case to the Minhang District Center for Disease Control and Prevention for investigation. The pneumonia diagnosis was confirmed.

However, microbloggers raised fears that they might have been infected by SARS.

The Shanghai Public Health Center, the city's designated facility for infectious disease diagnosis and treatment, did checks and ruled out the disease.

Officials from the Shanghai Health Bureau said the Shanghai Center for Disease Control and Prevention investigated the case and it, too, ruled out SARS.

The 55-year-old Li died of severe pneumonia and respiratory failure last week. The 87-year-old suffered multi-organ failure and died on Monday.

The 69-year-old is still in hospital, in isolation and receiving treatment.

Doctors said they were seeing a rising number of patients suffering from pneumonia due to the changing seasons. None of the other patients had any connection with the Li family.

SARS, or severe acute respiratory syndrome, is a serious and potentially life-threatening viral infection that mostly affects the lungs. It is caused by a family of viruses known as coronaviruses which can vary in their severity.

In the SARS epidemic in China 10 years ago, Shanghai had eight SARS patients, two of whom died. The Chinese mainland had 5,327 SARS patients during the epidemic, of whom 349 people died.

Shanghai Daily

[Giuseppe]

Re: China - 2 family members died of pneumonia, 1 hospitalized in stable condition - Government denies SARS, H5N1, NCoV and H1N1pdm09 - Shanghai

It cannot be SARS because the causative agent (SARS-CoV) went extinct.

Continuing rumors on SARS outbreaks are spreading without basis for purpose other than public health protection.

However, unexplained pneumonia clusters have to be carefully investigated in order to exclude other possible pathogens such as influenza viruses of animal origin, virulent antibiotics resistant bacteria, the NCoV, H5N1 etc.

[alert]

Re: China - 2 family members died of pneumonia, 1 hospitalized in stable condition - Government denies SARS, H5N1, NCoV and H1N1pdm09 - Shanghai

While the 2003 SARS virus is likely extinct in the wild, do not forget that there are hundreds of laboratories around the world that still have samples. In the year following the SARS outbreak, at least 3 separate incidents of laboratory-acquired infection occurred. So while future SARS cases are unlikely, they are not impossible.

I think the current suspicion by the Chinese authorities is that what they are dealing with is a cluster of a seasonal respiratory pathogen, perhaps aggravated by bacterial co-infection. I cannot help but notice that the ages involved are very similar to the cluster of respiratory fatalities reported in Maryland last year that were due to seasonal influenza and MRSA:

http://www.flutrackers.com/forum/showthread.php?t=183757

Sharon's initial post may indicate that the two fatal cases may have had pre-existing conditions.

[sharon sanders]

Re: China - 2 family members died of pneumonia, 1 hospitalized in stable condition - Government denies SARS, H5N1, NCoV and H1N1pdm09 - Shanghai

It is China. They are not forthcoming with the disease status there. So, really, we have no idea what is going on.


Shanghai, a three-acquired pneumonia in the two died
Social VientianeEvening News [ microblogging ] He Tianbao 2013-03-08 13:06I want to share 53
　　Original title: network transmission to a four-incidence "untrue
　　Evening News yesterday afternoon, users on the microblogging Shanghai Fifth People's Hospital a few cases of unidentified deaths, initially diagnosed as influenza, respiratory failure symptoms, hospital publish the truth, but then deleted the original post, and change The microblogging names. City Hospital, Shanghai Municipal Health Bureau yesterday successively through official microblogging clarification, verification by the health department, not a four sudden onset, hospital unreported and fifth cases. City Hospital has admitted a family of three, epidemiological investigation and laboratory detection, has been ruled out infectious diseases such as SARS.

zhttp://news.qq.com/a/20130308/001167.htm

[Shiloh]

Re: China - 2 family members died of pneumonia, 1 hospitalized in stable condition - Government denies SARS, H5N1, NCoV and H1N1pdm09 - Shanghai

Source: http://www.chinadaily.com.cn/china/2...t_16293034.htm


Health officials refute charge of flu-death cover-up
Updated: 2013-03-08 21:52
By Wang Zhenghua in Shanghai ( chinadaily.com.cn)

Medical authorities and a hospital in Shanghai have refuted a rumor that several people have died of flu and that the hospital withheld the information, the Shanghai Evening Post reported on March 8.

A netizen said in a post on a micro blog on March 7 evening that several people died of "unidentified illnesses" at Shanghai's No 5 People's Hospital, and urged the hospital to reveal the truth about the deaths.

Initial diagnoses found these deaths were linked to flu and respiratory failures, the web user said, who later deleted the post and changed the account name of the micro blog without explanation, the newspaper reported...

[sharon sanders]

These may have been the initial cases of the H7N9 human outbreak:

China - Three confirmed cases of human infection with H7N9 avian influenza - Two fatalities - March 31

http://www.flutrackers.com/forum/showthread.php?t=202694

[Laidback Al]

Re: China - 2 family members died of pneumonia, 1 hospitalized in stable condition - Government denies SARS, H5N1, NCoV and H1N1pdm09 - Shanghai

SARS ruled out in death cases

By Cai Wenjun | 2013-3-8

. . . . .

The hospital said three members of the Li [Lee] family had been admitted between February 14 and 24 for symptoms including a high fever and coughing.

All three, aged 55, 69 and 87, were diagnosed as having pneumonia.

Since they were from the same family, the hospital reported the case to the Minhang District Center for Disease Control and Prevention for investigation. The pneumonia diagnosis was confirmed.

However, microbloggers raised fears that they might have been infected by SARS.

The Shanghai Public Health Center, the city's designated facility for infectious disease diagnosis and treatment, did checks and ruled out the disease.

Officials from the Shanghai Health Bureau said the Shanghai Center for Disease Control and Prevention investigated the case and it, too, ruled out SARS.

The 55-year-old Li died of severe pneumonia and respiratory failure last week. The 87-year-old suffered multi-organ failure and died on Monday [March 4, 2013].

The 69-year-old is still in hospital, in isolation and receiving treatment.

It is fairly certain that the 87-year-old individual identified in this post is first official H7N9 case reported by China. The surname of the first case is Lee, he was 87 years old, and died on March 4, 2013 (link).

It may have been the Chinese micro bloggers in early March that forced China to report the new human infections of the H7N9 virus.

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[sharon sanders]

Re: China - 2 family members died of pneumonia, 1 hospitalized in stable condition - Government denies SARS, H5N1, NCoV and H1N1pdm09 - Shanghai

I think so and we owe those microbloggers a debt of gratitude.

From your Fellow Netizens - A Big Thank You.

[sharon sanders]

Re: China - 2 family members died of pneumonia, 1 hospitalized in stable condition - Government denies SARS, H5N1, NCoV and H1N1pdm09 - Shanghai - March 7, 2013

hat tip Michael Coston

China Confirms H7N9 Shanghai Family Cluster



Credit Wikipedia

# 7156

When it comes to proving human-to-human transmission of a virus not already known to transmit readily in that way, the bar is usually set pretty high.

If there are other, equally plausible explanations ? such as a common environmental exposure ? then H2H transmission cannot automatically be assumed.

This has been the standard used in evaluating H5N1 clusters for the past decade, and this seems to be the stance that experts in China have adopted regarding the suspected family cluster from early March, which Xinhua News is now reporting as being confirmed.

As you will recall, on March 31st (see More Details Emerge On Shanghai H7N9 Case) we first saw reports of three cases (2 in Shanghai, 1 in Anhui) that had been diagnosed with a new H7N9 virus.

While the two Shanghai cases were not linked, one of them ? an 87 year old man - had two sons who were hospitalized with pneumonia around the same time.

The Shanghai Daily reported:

According to Shanghai No. 5 People's Hospital, the three members of the Li family were admitted between February 14 and 24 for symptoms including a high fever and coughing.

All three were diagnosed as having pneumonia.

The 69-year-old son recovered and was discharged but the 55-year-old died from severe pneumonia and respiratory failure in late February. The father died of multi-organ failure.

Neither son had the H7N9 virus, the bureau said.

While always `suspect? cases, the sons have not been officially listed as having had the H7N9 virus. At least, not until today?s announcement.

This report from Xinhua News:

Family-clustered H7N9 cases unable to prove human-to-human transmission: expert

English.news.cn 2013-04-18 00:53:34
BEIJING, April 17 (Xinhua) -- The family-clustered H7N9 cases reported in Shanghai were unable to prove human-to-human transmission, an expert said Wednesday in an exclusive interview with Xinhua.

According to the National Health and Family Planning Commission, a man and one of his sons in Shanghai died from the bird flu, and his second son was also infected but has since recovered.

It has not been confirmed whether the three people contracted the virus from infected fowl or the contaminated environment or through human-to-human transmission, said Feng Zijian, an official with Chinese Center for Disease Control and Prevention.

Active screenings of human infections across the nation have not been required by the commission, and China will continue its current measures to prevent and control the spread of the H7N9, said Li Xingwang, an infectious disease expert of Beijing Ditan Hospital of the Capital Medical University.

Another, longer report, with a slightly different slant, appears today in China Daily.

Authorities test family infected by H7N9

Updated: 2013-04-18 01:59
By SHAN JUAN ( China Daily)
China's top health authority confirmed that a family infected by H7N9 in Shanghai might involve human-to-human transmission of the new bird flu strain.

The family involves two brothers and their 87-year-old father, who died on March 4 and was reportedly China's first human death from H7N9.

The elder son, who has recovered from the disease, was previously confirmed to have contracted the virus, the Chinese National Health and Family Planning Commission said on Wednesday at a media briefing.

However, the results of a test on the younger son were not available.

"Further investigations are still under way to figure out whether the family cluster involved human-to-human transmission," said Feng Zijian, director of the health emergency center of the Chinese Center for Disease Control and Prevention.

(Continue . . . )

It seems likely that these two cases were among the 5 `retrospective diagnoses? announced yesterday (see China: Six more H7N9 Cases - 77 Total, 16 Fatalities), although no identifying details were given at the time.


Given the suspicious circumstances, the revelation that the man and his two sons are now accepted as being part of a cluster is hardly a game changer.

While not proven in this case, we?ve seen limited human-to-human transmission of other avian viruses in the past, and so it would not be unexpected that we could see it with H7N9 as well.

The good news is that, what officials say they?ve not seen are any signs of ongoing, efficient, or sustained human transmission of this virus.

But at the same time, exactly how more than 80 people - across several provinces - have come to be infected by this emerging avian virus over the past month or so remains a mystery.

Stay tuned.

Posted by Michael Coston at <a class="timestamp-link" href="http://afludiary.blogspot.com/2013/04/china-confirms-h7n9-shanghai-family.html" rel="bookmark" title="permanent link"><abbr class="published" title="2013-04-17T14:40:00-04:00">2:40 PM</abbr>

[Giuseppe]

Re: China - 2 family members died of pneumonia, 1 hospitalized in stable condition - Government denies SARS, H5N1, NCoV and H1N1pdm09 - Shanghai - March 7, 2013

[Source: Ifeng, full text: (LINK). Automatic translation from Chinese.]

H7N9, Shanghai: A possible familiar cluster of birdflu cases

18 May 2013 03:05 Source: Beijing Times


Beijing Times News - 87-year-old Lee is the first case of human infection with the H7N9 avian influenza confirmed cases, and therefore death. The national guard Planning Commission, introduced yesterday, with Lee admitted to hospital for treatment of his two sons, the eldest son has been cured by serum testing confirmed infected with the H7N9 virus, Lee youngest son has died unable to collect specimens. This was a case of familial aggregation.

Poster Retrospective diagnosed cases in the previous night, including Shanghai Lee family of three cases of pneumonia of unknown causes.

Feng Zijian, director of the Chinese Center for Disease Control Health Emergency Center said at the press conference yesterday, several cases including patients with the first confirmed cases of Lee's eldest son, he was diagnosed patients sera. In this way, Li 2 in 3 patients have been diagnosed with, another person has died can not collect specimens.

This familial cluster of cases, as the father and sons co-exposure to poultry or pollute the environment or between infection caused, is still under investigation, there is no final conclusions. But even a small number of cases of familial aggregation, does not mean that the virus has the ability to have effective human-to-human transmission.

Once it is how to deal with human-to-human transmission occurs, Feng Zijian, China developed influenza pandemic contingency plans, has taken appropriate preparations for pandemic response.

Earlier reports said that the H7N9 virus is mutating at an alarming rate, even given the new avian flu virus mutation rate may be 8 times faster than ordinary flu virus figures. Feng Zijian pointed out that the virus is not as fast variation. Him, just to get the patient's virus samples are doing testing, such as the timely publication of the results came out.


Focus and infectious

A small number of cases of familial aggregation is not equal to the effective human-to-human transmission

Recently, the Hong Kong Health Department issued a notice that the medical institutions in Hong Kong, close contact with a very slight possibility of human-to-human transmission.

Feng Zijian, this view of public health agencies in Hong Kong, but also make a guess based on the cases of familial aggregation phenomenon see, the Chinese Center for Disease Control also highly concerned about this family clusters of cases, and in-depth analysis which possibilities is the first occurrence of avian-to-human transmission, human-to-human infections, or patients with common history of exposure or were exposed to contaminated objects or the environment.

However, even a small number of cases of familial aggregation, does not mean that the virus has had the ability to effective human-to-human transmission.

Feng Zijian, H5N1 was found for the first time be able to infect humans, from family clusters of cases occurred up to now, has lasted more than a decade, remained infection from birds to people, and the number of infections is limited, worldwide in hundreds, China a total of 45 cases.

He stressed that there is no evidence that H7N9 continued infection, not only is the Chinese Center for Disease Control, which is the international public health agencies and disease control institutions common understanding of the virus.


Dispel doubts - Limited human-to-human transmission and more parent-child relationship

Feng Zijian, human-to-human transmission of limited human-to-human transmission and effective human-to-human transmission, that is sustained human-to-human transmission.

The former refers to such human-to-human transmission is very accidental, mostly related susceptibility and the family, the patient is often the parent-child relationship, genetic susceptibility is genetically related to a few specific people in the crowd with some susceptible physiological mechanism, so that he can be infected. This case does not appear multiple generations of infection, at most, a second-generation patients, three generations of patients and more patients will no longer appear, but generally does not appear to a person infected a number of secondary cases, this is the limited human-to-human transmission.

When the disease evolved into a human influenza virus is effective human-to-human transmission. We often see during a pandemic of influenza A H1N1 influenza outbreak crowd, such as at school or in the community, many patients, a patient can infect a number of patients can continue to spread, you can see a clear chain of transmission, the disease can also be far from the spread, which is the effective human-to-human transmission.


questioning - Market of live birds "scalding" to suspect

Since poultry infection, why about 40% of those infected poultry or poultry market exposure history?

Feng Zijian pointed out that not every patient can clearly recall the history of exposure. Inferred or poultry contaminated environment or direct contact with poultry that exposure to infection from birds to people, and then lead to infection.

"We recognize that an important city of live poultry markets and sell freshly slaughtered cause disease risk factors." Said Feng Zijian, the market in live poultry stalls often hair removal device, which has hot water, put the chicken inside the high-speed rotation, easy to form aerosols, if any virus, may inhale through the neighborhood. This is also the experts suspect that the important cause human infections exposed to the environment.


Vaccine using the object has not yet been finalized

For vaccine development, Feng Zijian, this stage vaccine research work is the choice of the strain to determine the route of vaccine production technology is selected recombinant or virus itself directly culture production, and then inactivated vaccine preparation, and now these are not yet determined, are in the research stage. The use of vaccines developed out object, using the strategy have to wait a period of time have the answer.


In the late pregnant women infected with high-risk

Media groups of pregnant women, prevention, diagnosis and treatment of the problem, Beijing Ditan Hospital infectious disease treatment center director Li Xingwang Judging from the experience in the treatment of influenza, at 27 weeks, before the early pregnancy, pregnant women feel and general no difference. Doctors are more concerned about in the late pregnant women, this population is infected with influenza high-risk groups. In the treatment to be positive, but in the middle and late after the drugs may have certain effects on the fetus. As for the early pregnant women, but also to do the assessment.


Public panic is necessary for the detection

With the development of the epidemic, there have been some panic offered to detect the phenomenon.

Feng Zijian, such as fever, cough, upper respiratory tract infection symptoms, consult a doctor as soon as possible be done to detect the recommendations given by doctors. But there is no need to to medical institutions or to disease control agencies to seek detection, especially in the absence of symptoms. "For example, I heard someone say, some people eat in the morning eggs, suddenly heard the reports of avian influenza, there are no symptoms, they went to the hospital required to detect, it is not necessary."


latest outbreak of 82 cases of confirmed

National guard Planning Commission announced yesterday, 17:00 As of yesterday, the country reported a total of 82 cases of human infection with the H7N9 avian influenza confirmed cases, 5 of them have been cured, the death of 17 people, and the remaining 60 are each designated medical unit for treatment.

At 20 o'clock on the the 16th at 17:00 on the 17th, the national report five cases of new confirmed cases, including Shanghai, Zhejiang.

Up to now, the distribution of reported cases in Beijing (1) Shanghai (31 cases and 11 deaths), Jiangsu (20 patients, 3 patients died), Zhejiang (25 cases and 2 deaths), Anhui (3 cases, 1 death cases), 6 provinces of Henan (2) 30 to the municipal area. Has not yet found evidence of human-to-human transmission.


Zhejiang new 4 cases of live poultry cooked-virus

Zhejiang Province in the new cases, three cases who lives in Hangzhou . They are the 11th incidence of 37-year-old female farmer Liaomou onset of 74-year-old retired male employees of a cow, as well as the onset of the 86-year-old retired worker in the 13th Zhao. Another example from Huzhou, cadres of the 41-year-old man Zhang. Earlier, the authorities were detected in both the live poultry trade center and live poultry stalls selling live poultry samples or external environment H7N9 virus nucleic acid positive.

Currently, Zhang mild symptoms, Liao, cattle, Zhao per capita was seriously ill.


The pig not now stained virus

Yesterday, the Information Office of the Ministry of Agriculture announced that, as of now, only in the the sample and feral pigeons samples of live poultry market in the H7N9 avian influenza virus isolated in the livestock and poultry farms, wild bird habitats and slaughterhouse samples collected unseparated H7N9 avian influenza virus, poultry farms around the investigation and no abnormal situation. Currently monitoring the situation and found no pigs infected with the H7N9 avian influenza virus, people normally buy pork consumption of formal channels. (Reporter quiet) In addition to the signature edition have written the Jinghua Times reporter Zhang Ran

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