[Source: Ifeng, full text: (LINK). Automatic translation from Chinese.]
H7N9, Shanghai: A possible familiar cluster of birdflu cases
18 May 2013 03:05 Source: Beijing Times
Beijing Times News - 87-year-old Lee is the first case of human infection with the H7N9 avian influenza confirmed cases, and therefore death. The national guard Planning Commission, introduced yesterday, with Lee admitted to hospital for treatment of his two sons, the eldest son has been cured by serum testing confirmed infected with the H7N9 virus, Lee youngest son has died unable to collect specimens. This was a case of familial aggregation.
Poster Retrospective diagnosed cases in the previous night, including Shanghai Lee family of three cases of pneumonia of unknown causes.
Feng Zijian, director of the Chinese Center for Disease Control Health Emergency Center said at the press conference yesterday, several cases including patients with the first confirmed cases of Lee's eldest son, he was diagnosed patients sera. In this way, Li 2 in 3 patients have been diagnosed with, another person has died can not collect specimens.
This familial cluster of cases, as the father and sons co-exposure to poultry or pollute the environment or between infection caused, is still under investigation, there is no final conclusions. But even a small number of cases of familial aggregation, does not mean that the virus has the ability to have effective human-to-human transmission.
Once it is how to deal with human-to-human transmission occurs, Feng Zijian, China developed influenza pandemic contingency plans, has taken appropriate preparations for pandemic response.
Earlier reports said that the H7N9 virus is mutating at an alarming rate, even given the new avian flu virus mutation rate may be 8 times faster than ordinary flu virus figures. Feng Zijian pointed out that the virus is not as fast variation. Him, just to get the patient's virus samples are doing testing, such as the timely publication of the results came out.
Focus and infectious
A small number of cases of familial aggregation is not equal to the effective human-to-human transmission
Recently, the Hong Kong Health Department issued a notice that the medical institutions in Hong Kong, close contact with a very slight possibility of human-to-human transmission.
Feng Zijian, this view of public health agencies in Hong Kong, but also make a guess based on the cases of familial aggregation phenomenon see, the Chinese Center for Disease Control also highly concerned about this family clusters of cases, and in-depth analysis which possibilities is the first occurrence of avian-to-human transmission, human-to-human infections, or patients with common history of exposure or were exposed to contaminated objects or the environment.
However, even a small number of cases of familial aggregation, does not mean that the virus has had the ability to effective human-to-human transmission.
Feng Zijian, H5N1 was found for the first time be able to infect humans, from family clusters of cases occurred up to now, has lasted more than a decade, remained infection from birds to people, and the number of infections is limited, worldwide in hundreds, China a total of 45 cases.
He stressed that there is no evidence that H7N9 continued infection, not only is the Chinese Center for Disease Control, which is the international public health agencies and disease control institutions common understanding of the virus.
Dispel doubts - Limited human-to-human transmission and more parent-child relationship
Feng Zijian, human-to-human transmission of limited human-to-human transmission and effective human-to-human transmission, that is sustained human-to-human transmission.
The former refers to such human-to-human transmission is very accidental, mostly related susceptibility and the family, the patient is often the parent-child relationship, genetic susceptibility is genetically related to a few specific people in the crowd with some susceptible physiological mechanism, so that he can be infected. This case does not appear multiple generations of infection, at most, a second-generation patients, three generations of patients and more patients will no longer appear, but generally does not appear to a person infected a number of secondary cases, this is the limited human-to-human transmission.
When the disease evolved into a human influenza virus is effective human-to-human transmission. We often see during a pandemic of influenza A H1N1 influenza outbreak crowd, such as at school or in the community, many patients, a patient can infect a number of patients can continue to spread, you can see a clear chain of transmission, the disease can also be far from the spread, which is the effective human-to-human transmission.
questioning - Market of live birds "scalding" to suspect
Since poultry infection, why about 40% of those infected poultry or poultry market exposure history?
18 May 2013 03:05 Source: Beijing Times
Beijing Times News - 87-year-old Lee is the first case of human infection with the H7N9 avian influenza confirmed cases, and therefore death. The national guard Planning Commission, introduced yesterday, with Lee admitted to hospital for treatment of his two sons, the eldest son has been cured by serum testing confirmed infected with the H7N9 virus, Lee youngest son has died unable to collect specimens. This was a case of familial aggregation.
Poster Retrospective diagnosed cases in the previous night, including Shanghai Lee family of three cases of pneumonia of unknown causes.
Feng Zijian, director of the Chinese Center for Disease Control Health Emergency Center said at the press conference yesterday, several cases including patients with the first confirmed cases of Lee's eldest son, he was diagnosed patients sera. In this way, Li 2 in 3 patients have been diagnosed with, another person has died can not collect specimens.
This familial cluster of cases, as the father and sons co-exposure to poultry or pollute the environment or between infection caused, is still under investigation, there is no final conclusions. But even a small number of cases of familial aggregation, does not mean that the virus has the ability to have effective human-to-human transmission.
Once it is how to deal with human-to-human transmission occurs, Feng Zijian, China developed influenza pandemic contingency plans, has taken appropriate preparations for pandemic response.
Earlier reports said that the H7N9 virus is mutating at an alarming rate, even given the new avian flu virus mutation rate may be 8 times faster than ordinary flu virus figures. Feng Zijian pointed out that the virus is not as fast variation. Him, just to get the patient's virus samples are doing testing, such as the timely publication of the results came out.
Focus and infectious
A small number of cases of familial aggregation is not equal to the effective human-to-human transmission
Recently, the Hong Kong Health Department issued a notice that the medical institutions in Hong Kong, close contact with a very slight possibility of human-to-human transmission.
Feng Zijian, this view of public health agencies in Hong Kong, but also make a guess based on the cases of familial aggregation phenomenon see, the Chinese Center for Disease Control also highly concerned about this family clusters of cases, and in-depth analysis which possibilities is the first occurrence of avian-to-human transmission, human-to-human infections, or patients with common history of exposure or were exposed to contaminated objects or the environment.
However, even a small number of cases of familial aggregation, does not mean that the virus has had the ability to effective human-to-human transmission.
Feng Zijian, H5N1 was found for the first time be able to infect humans, from family clusters of cases occurred up to now, has lasted more than a decade, remained infection from birds to people, and the number of infections is limited, worldwide in hundreds, China a total of 45 cases.
He stressed that there is no evidence that H7N9 continued infection, not only is the Chinese Center for Disease Control, which is the international public health agencies and disease control institutions common understanding of the virus.
Dispel doubts - Limited human-to-human transmission and more parent-child relationship
Feng Zijian, human-to-human transmission of limited human-to-human transmission and effective human-to-human transmission, that is sustained human-to-human transmission.
The former refers to such human-to-human transmission is very accidental, mostly related susceptibility and the family, the patient is often the parent-child relationship, genetic susceptibility is genetically related to a few specific people in the crowd with some susceptible physiological mechanism, so that he can be infected. This case does not appear multiple generations of infection, at most, a second-generation patients, three generations of patients and more patients will no longer appear, but generally does not appear to a person infected a number of secondary cases, this is the limited human-to-human transmission.
When the disease evolved into a human influenza virus is effective human-to-human transmission. We often see during a pandemic of influenza A H1N1 influenza outbreak crowd, such as at school or in the community, many patients, a patient can infect a number of patients can continue to spread, you can see a clear chain of transmission, the disease can also be far from the spread, which is the effective human-to-human transmission.
questioning - Market of live birds "scalding" to suspect
Since poultry infection, why about 40% of those infected poultry or poultry market exposure history?
Feng Zijian pointed out that not every patient can clearly recall the history of exposure. Inferred or poultry contaminated environment or direct contact with poultry that exposure to infection from birds to people, and then lead to infection.
"We recognize that an important city of live poultry markets and sell freshly slaughtered cause disease risk factors." Said Feng Zijian, the market in live poultry stalls often hair removal device, which has hot water, put the chicken inside the high-speed rotation, easy to form aerosols, if any virus, may inhale through the neighborhood. This is also the experts suspect that the important cause human infections exposed to the environment.
Vaccine using the object has not yet been finalized
For vaccine development, Feng Zijian, this stage vaccine research work is the choice of the strain to determine the route of vaccine production technology is selected recombinant or virus itself directly culture production, and then inactivated vaccine preparation, and now these are not yet determined, are in the research stage. The use of vaccines developed out object, using the strategy have to wait a period of time have the answer.
In the late pregnant women infected with high-risk
Media groups of pregnant women, prevention, diagnosis and treatment of the problem, Beijing Ditan Hospital infectious disease treatment center director Li Xingwang Judging from the experience in the treatment of influenza, at 27 weeks, before the early pregnancy, pregnant women feel and general no difference. Doctors are more concerned about in the late pregnant women, this population is infected with influenza high-risk groups. In the treatment to be positive, but in the middle and late after the drugs may have certain effects on the fetus. As for the early pregnant women, but also to do the assessment.
Public panic is necessary for the detection
With the development of the epidemic, there have been some panic offered to detect the phenomenon.
Feng Zijian, such as fever, cough, upper respiratory tract infection symptoms, consult a doctor as soon as possible be done to detect the recommendations given by doctors. But there is no need to to medical institutions or to disease control agencies to seek detection, especially in the absence of symptoms. "For example, I heard someone say, some people eat in the morning eggs, suddenly heard the reports of avian influenza, there are no symptoms, they went to the hospital required to detect, it is not necessary."
latest outbreak of 82 cases of confirmed
National guard Planning Commission announced yesterday, 17:00 As of yesterday, the country reported a total of 82 cases of human infection with the H7N9 avian influenza confirmed cases, 5 of them have been cured, the death of 17 people, and the remaining 60 are each designated medical unit for treatment.
At 20 o'clock on the the 16th at 17:00 on the 17th, the national report five cases of new confirmed cases, including Shanghai, Zhejiang.
Up to now, the distribution of reported cases in Beijing (1) Shanghai (31 cases and 11 deaths), Jiangsu (20 patients, 3 patients died), Zhejiang (25 cases and 2 deaths), Anhui (3 cases, 1 death cases), 6 provinces of Henan (2) 30 to the municipal area. Has not yet found evidence of human-to-human transmission.
Zhejiang new 4 cases of live poultry cooked-virus
Zhejiang Province in the new cases, three cases who lives in Hangzhou . They are the 11th incidence of 37-year-old female farmer Liaomou onset of 74-year-old retired male employees of a cow, as well as the onset of the 86-year-old retired worker in the 13th Zhao. Another example from Huzhou, cadres of the 41-year-old man Zhang. Earlier, the authorities were detected in both the live poultry trade center and live poultry stalls selling live poultry samples or external environment H7N9 virus nucleic acid positive.
Currently, Zhang mild symptoms, Liao, cattle, Zhao per capita was seriously ill.
The pig not now stained virus
Yesterday, the Information Office of the Ministry of Agriculture announced that, as of now, only in the the sample and feral pigeons samples of live poultry market in the H7N9 avian influenza virus isolated in the livestock and poultry farms, wild bird habitats and slaughterhouse samples collected unseparated H7N9 avian influenza virus, poultry farms around the investigation and no abnormal situation. Currently monitoring the situation and found no pigs infected with the H7N9 avian influenza virus, people normally buy pork consumption of formal channels. (Reporter quiet) In addition to the signature edition have written the Jinghua Times reporter Zhang Ran
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