Pathfinder
Editor, Senior Moderator
Brief ReportSwitch to Standard View
Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation
Hongda Li5, Laura Saucedo-Cuevas5, Jose A. Regla-Nava, Guoliang Chai, Nicholas Sheets, William Tang, Alexey V. Terskikh, Sujan ShrestacorrespondencePress enter key for correspondence informationemailPress enter key to Email the author, Joseph G. Gleeson6,correspondencePress enter key for correspondence informationemailPress enter key to Email the author
5Co-first author
6Lead Contact
Publication stage: In Press Corrected Proof
DOI: http://dx.doi.org/10.1016/j.stem.2016.08.005
showArticle Info
...
ZIKV infection can lead to caspase-3 (CASP3) activation in both NPCs differentiated from human ESCs/IPSCs and embryonic mouse brain (Cugola et al., 2016, Miner et al., 2016). In order to determine whether systemic ZIKV infection can induce cell death in adult NPC populations, we stained for cleaved (i.e., activated) CASP3 in NPC niches. Mock-infected TKO mice showed scant evidence of CASP3+ cells. In contrast abundant CASP3+ cells were detected in ZIKV-infected brains within these neurogenic niches (Figures 2A?2D), and were also usually positive for Nestin. Similarly, the ZIKV staining colocalized with CASP3 in NPCs in the SVZ and SGZ (Figures S2I and S2J), suggesting that ZIKV infection can induce apoptotic cell death in adult NPCs in these regions.
...
Full text:
http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(16)30252-1
Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation
Hongda Li5, Laura Saucedo-Cuevas5, Jose A. Regla-Nava, Guoliang Chai, Nicholas Sheets, William Tang, Alexey V. Terskikh, Sujan ShrestacorrespondencePress enter key for correspondence informationemailPress enter key to Email the author, Joseph G. Gleeson6,correspondencePress enter key for correspondence informationemailPress enter key to Email the author
5Co-first author
6Lead Contact
Publication stage: In Press Corrected Proof
DOI: http://dx.doi.org/10.1016/j.stem.2016.08.005
showArticle Info
...
ZIKV infection can lead to caspase-3 (CASP3) activation in both NPCs differentiated from human ESCs/IPSCs and embryonic mouse brain (Cugola et al., 2016, Miner et al., 2016). In order to determine whether systemic ZIKV infection can induce cell death in adult NPC populations, we stained for cleaved (i.e., activated) CASP3 in NPC niches. Mock-infected TKO mice showed scant evidence of CASP3+ cells. In contrast abundant CASP3+ cells were detected in ZIKV-infected brains within these neurogenic niches (Figures 2A?2D), and were also usually positive for Nestin. Similarly, the ZIKV staining colocalized with CASP3 in NPCs in the SVZ and SGZ (Figures S2I and S2J), suggesting that ZIKV infection can induce apoptotic cell death in adult NPCs in these regions.
...
Full text:
http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(16)30252-1