Pathfinder
Editor, Senior Moderator
[h=1]Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears[/h] Jonathan J. Miner9,
Press enter key for correspondence information
Press enter key to Email the author
, Abdoulaye Sene9
, Justin M. Richner
, Amber M. Smith
, Andrea Santeford
, Norimitsu Ban
, James Weger-Lucarelli
, Francesca Manzella
, Claudia R?ckert
, Jennifer Govero
, Kevin K. Noguchi
, Gregory D. Ebel
, Michael S. Diamond10,
Press enter key for correspondence informationPress enter key to Email the author
, Rajendra S. Apte
Press enter key for correspondence informationPress enter key to Email the author
9Co-first author
10Lead Contact
Publication stage: In Press Corrected Proof
Open Access
DOI: http://dx.doi.org/10.1016/j.celrep.2016.08.079
[h=2]
Article Info[/h]
[h=2]Introduction[/h] ZIKV is a mosquito-transmitted flavivirus that is closely related to Dengue (DENV), West Nile (WNV), and yellow fever (YFV) viruses. Beyond the clinical syndromes of microcephaly, intrauterine growth restriction, and fetal demise, several clinical studies have observed eye malformations and pathology in neonates born to mothers infected with ZIKV during pregnancy (de Paula Freitas et al., 2016, McCarthy, 2016, Miranda et al., 2016, Sarno et al., 2016, Ventura et al., 2016a, Ventura et al., 2016b). Manifestations of eye disease in newborns with ZIKV include chorioretinal atrophy, optic neuritis, bilateral iris colobomas, intraretinal hemorrhages, lens subluxation, and blindness (de Paula Freitas et al., 2016, Miranda et al., 2016, Ventura et al., 2016a, Ventura et al., 2016b).
Viral infection in the eye can cause inflammation of uveal tissues (retina, choroid, iris, and ciliary body), also termed uveitis, which can lead to permanent vision loss if untreated (Niederkorn, 2006). In 2014, an Ebola virus (EBOV)-infected patient in the convalescent phase presented with uveitis. The aqueous humor of this patient?s eye contained persistent EBOV RNA well after clearance of the virus in non-immune-privileged sites (Varkey et al., 2015). A subsequent study identified 57 EBOV survivors with uveitis, suggesting that infectious virus or viral RNA in the eye might have triggered this complication (Tiffany et al., 2016). Other animal models have suggested that some DNA viruses (e.g., ectromelia virus) might persist in the eye and recrudesce after immunosuppression (Sakala et al., 2015). ZIKV causes conjunctivitis in 10% to 15% of infected adults, and uveitis occurred in a patient several weeks after initial infection. Fluid sampled from the anterior chamber of this patient?s eye contained viral RNA (Furtado et al., 2016), suggesting that ZIKV can replicate within the eye at some stage of its clinical syndrome.
...
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31175-5
Press enter key to Email the author, Abdoulaye Sene9
, Justin M. Richner
, Amber M. Smith
, Andrea Santeford
, Norimitsu Ban
, James Weger-Lucarelli
, Francesca Manzella
, Claudia R?ckert
, Jennifer Govero
, Kevin K. Noguchi
, Gregory D. Ebel
, Michael S. Diamond10,
Press enter key to Email the author, Rajendra S. Apte
Press enter key to Email the author9Co-first author
10Lead Contact
Publication stage: In Press Corrected Proof
Open Access
DOI: http://dx.doi.org/10.1016/j.celrep.2016.08.079
[h=2]
Article Info[/h] [h=2]Introduction[/h] ZIKV is a mosquito-transmitted flavivirus that is closely related to Dengue (DENV), West Nile (WNV), and yellow fever (YFV) viruses. Beyond the clinical syndromes of microcephaly, intrauterine growth restriction, and fetal demise, several clinical studies have observed eye malformations and pathology in neonates born to mothers infected with ZIKV during pregnancy (de Paula Freitas et al., 2016, McCarthy, 2016, Miranda et al., 2016, Sarno et al., 2016, Ventura et al., 2016a, Ventura et al., 2016b). Manifestations of eye disease in newborns with ZIKV include chorioretinal atrophy, optic neuritis, bilateral iris colobomas, intraretinal hemorrhages, lens subluxation, and blindness (de Paula Freitas et al., 2016, Miranda et al., 2016, Ventura et al., 2016a, Ventura et al., 2016b).
Viral infection in the eye can cause inflammation of uveal tissues (retina, choroid, iris, and ciliary body), also termed uveitis, which can lead to permanent vision loss if untreated (Niederkorn, 2006). In 2014, an Ebola virus (EBOV)-infected patient in the convalescent phase presented with uveitis. The aqueous humor of this patient?s eye contained persistent EBOV RNA well after clearance of the virus in non-immune-privileged sites (Varkey et al., 2015). A subsequent study identified 57 EBOV survivors with uveitis, suggesting that infectious virus or viral RNA in the eye might have triggered this complication (Tiffany et al., 2016). Other animal models have suggested that some DNA viruses (e.g., ectromelia virus) might persist in the eye and recrudesce after immunosuppression (Sakala et al., 2015). ZIKV causes conjunctivitis in 10% to 15% of infected adults, and uveitis occurred in a patient several weeks after initial infection. Fluid sampled from the anterior chamber of this patient?s eye contained viral RNA (Furtado et al., 2016), suggesting that ZIKV can replicate within the eye at some stage of its clinical syndrome.
...
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)31175-5