tetano
Editor, Senior Moderator
Zhongguo Dang Dai Er Ke Za Zhi
. 2022 Feb 15;24(2):216-222.
doi: 10.7499/j.issn.1008-8830.2111005.
Recent research on the application of biologics in the treatment of multisystem inflammatory syndrome in children after SARS-CoV-2 infection
[Article in English, Chinese]
Han-Yu Cui[SUP] 1 [/SUP], Chang-Ping Hu[SUP] 1 [/SUP]
Affiliations
Abstract
in English, Chinese
Multisystem inflammatory syndrome in children (MIS-C) is a type of hyperinflammatory symptoms similar to Kawasaki disease after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and is commonly observed in children aged 8-10 years. Primary therapeutic medications for MIS-C are intravenous immunoglobulins and glucocorticoids. It has been reported that biologics, such as IL-1 receptor antagonist anakinra, IL-6 receptor antagonist tocilizumab, and TNF-α receptor antagonist infliximab, can be used as an option for critically ill patients. This article elaborates on the mechanism of action of the above biologics and discusses the efficacy and safety biologics in the treatment of MIS-C after SARS-CoV-2 infection, in order to provide methods for the treatment of MIS-C with severe symptoms.
Keywords: Biologics; Child; Multisystem inflammatory syndrome; Severe acute respiratory syndrome coronavirus 2.
. 2022 Feb 15;24(2):216-222.
doi: 10.7499/j.issn.1008-8830.2111005.
Recent research on the application of biologics in the treatment of multisystem inflammatory syndrome in children after SARS-CoV-2 infection
[Article in English, Chinese]
Han-Yu Cui[SUP] 1 [/SUP], Chang-Ping Hu[SUP] 1 [/SUP]
Affiliations
- PMID: 35209989
- DOI: 10.7499/j.issn.1008-8830.2111005
Abstract
in English, Chinese
Multisystem inflammatory syndrome in children (MIS-C) is a type of hyperinflammatory symptoms similar to Kawasaki disease after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and is commonly observed in children aged 8-10 years. Primary therapeutic medications for MIS-C are intravenous immunoglobulins and glucocorticoids. It has been reported that biologics, such as IL-1 receptor antagonist anakinra, IL-6 receptor antagonist tocilizumab, and TNF-α receptor antagonist infliximab, can be used as an option for critically ill patients. This article elaborates on the mechanism of action of the above biologics and discusses the efficacy and safety biologics in the treatment of MIS-C after SARS-CoV-2 infection, in order to provide methods for the treatment of MIS-C with severe symptoms.
Keywords: Biologics; Child; Multisystem inflammatory syndrome; Severe acute respiratory syndrome coronavirus 2.