tetano
Editor, Senior Moderator
Z Gesundh Wiss. 2020 Apr 21:1-4. doi: 10.1007/s10389-020-01291-2. [Epub ahead of print]
The clinical data from 19 critically ill patients with coronavirus disease 2019: a single-centered, retrospective, observational study.
Zhang J[SUP]#[/SUP][SUP]1[/SUP], Liu P[SUP]#[/SUP][SUP]2[/SUP], Wang M[SUP]1[/SUP], Wang J[SUP]1[/SUP], Chen J[SUP]1[/SUP], Yuan W[SUP]1[/SUP], Li M[SUP]1[/SUP], Xie Z[SUP]1[/SUP], Dong W[SUP]1[/SUP], Li H[SUP]1[/SUP], Zhao Y[SUP]1[/SUP], Wan L[SUP]1[/SUP], Chu T[SUP]1[/SUP], Wang L[SUP]1[/SUP], Zhang H[SUP]1[/SUP], Tao T[SUP]1[/SUP], Ma J[SUP]1[/SUP].
Author information
Abstract
Background:
The objectives of this study were to analyze the clinical features of coronavirus disease 2019 (COVID-19) and evaluate the diagnosis and treatment.
Methods:
A retrospective analysis of the clinical manifestation and auxiliary examination of 19 patients with COVID-19 from the Liyuan Hospital intensive care unit (ICU) between January 16, 2020 and February 20, 2020 was undertaken.
Results:
There were 11 male and 8 female cases among the patients. The median (range) age was 73 (38-91) years. Of these patients, 8 (42.1%) had died and the median duration from ICU admission to death was 2 (interquartile range (IQR): 1-10.75) days. Seven of these 8 patients had underlying diseases. The auxiliary examination showed fever (68.4%), dry cough (15.8%), dyspnea (10.5%), and diarrhea (5.3%). All 19 cases showed ground-glass changes on chest computed tomography. Serum hypersensitive C-reactive protein (hs-CRP) and serum amylase A (SAA) were clearly increased in all of the cases. Among the 19 cases, there were 16 (84.2%) cases in which the total number of lymphocytes decreased, 12 cases (63%) had reduced liver function, and 11 cases (58%) had deviant results for fibrinogen (FIB) and D-dimer, in particular, the D-dimer level was significantly higher in the non-survivors compared with the survivors.
Conclusion:
There were more men than women among critically ill patients. All of the cases showed ground-glass changes on chest computed tomography and the vast majority of patients displayed fever and dry cough. The clinical laboratory indices change significantly, especially the D-dimer level among non-survivors.
? Springer-Verlag GmbH Germany, part of Springer Nature 2020.
KEYWORDS:
Clinical manifestations; Coronavirus disease 2019; D-dimer; Epidemiology; Retrospective
PMID:32318325PMCID:PMC7171052DOI:10.1007/s10389-020-01291-2
The clinical data from 19 critically ill patients with coronavirus disease 2019: a single-centered, retrospective, observational study.
Zhang J[SUP]#[/SUP][SUP]1[/SUP], Liu P[SUP]#[/SUP][SUP]2[/SUP], Wang M[SUP]1[/SUP], Wang J[SUP]1[/SUP], Chen J[SUP]1[/SUP], Yuan W[SUP]1[/SUP], Li M[SUP]1[/SUP], Xie Z[SUP]1[/SUP], Dong W[SUP]1[/SUP], Li H[SUP]1[/SUP], Zhao Y[SUP]1[/SUP], Wan L[SUP]1[/SUP], Chu T[SUP]1[/SUP], Wang L[SUP]1[/SUP], Zhang H[SUP]1[/SUP], Tao T[SUP]1[/SUP], Ma J[SUP]1[/SUP].
Author information
Abstract
Background:
The objectives of this study were to analyze the clinical features of coronavirus disease 2019 (COVID-19) and evaluate the diagnosis and treatment.
Methods:
A retrospective analysis of the clinical manifestation and auxiliary examination of 19 patients with COVID-19 from the Liyuan Hospital intensive care unit (ICU) between January 16, 2020 and February 20, 2020 was undertaken.
Results:
There were 11 male and 8 female cases among the patients. The median (range) age was 73 (38-91) years. Of these patients, 8 (42.1%) had died and the median duration from ICU admission to death was 2 (interquartile range (IQR): 1-10.75) days. Seven of these 8 patients had underlying diseases. The auxiliary examination showed fever (68.4%), dry cough (15.8%), dyspnea (10.5%), and diarrhea (5.3%). All 19 cases showed ground-glass changes on chest computed tomography. Serum hypersensitive C-reactive protein (hs-CRP) and serum amylase A (SAA) were clearly increased in all of the cases. Among the 19 cases, there were 16 (84.2%) cases in which the total number of lymphocytes decreased, 12 cases (63%) had reduced liver function, and 11 cases (58%) had deviant results for fibrinogen (FIB) and D-dimer, in particular, the D-dimer level was significantly higher in the non-survivors compared with the survivors.
Conclusion:
There were more men than women among critically ill patients. All of the cases showed ground-glass changes on chest computed tomography and the vast majority of patients displayed fever and dry cough. The clinical laboratory indices change significantly, especially the D-dimer level among non-survivors.
? Springer-Verlag GmbH Germany, part of Springer Nature 2020.
KEYWORDS:
Clinical manifestations; Coronavirus disease 2019; D-dimer; Epidemiology; Retrospective
PMID:32318325PMCID:PMC7171052DOI:10.1007/s10389-020-01291-2