tetano
Editor, Senior Moderator
Yonsei Med J
. 2020 Oct;61(10):891-894.
doi: 10.3349/ymj.2020.61.10.891.
Quantitative Proteomic Analysis of the Expression of SARS-CoV-2 Receptors in the Gut of Patients with Chronic Enterocolitis
Jihye Park[SUP] 1 2 [/SUP], Daeun Jeong[SUP] 3 4 [/SUP], Youn Wook Chung[SUP] 3 5 [/SUP], Da Hye Kim[SUP] 3 [/SUP], Jae Hee Cheon[SUP] 1 2 6 [/SUP], Ji Hwan Ryu[SUP] 3 7 [/SUP]
Affiliations
Abstract
The cellular entry of severe respiratory syndrome coronavirus-2 (SARS-CoV-2) is mediated by interaction with the human angiotensin-converting enzyme 2 (ACE2), a receptor that is expressed on both lung and intestinal epithelial cells. We performed a quantitative proteomic analysis to investigate the expression of possible receptors for SARS-CoV-2 in the intestinal mucosa of 23 patients with chronic colitis. ACE2 expression was low and remained unaltered in the gut of patients with ulcerative colitis (UC), Crohn's disease (CD), intestinal Behćet's disease (BD), and intestinal tuberculosis (TB), when compared with that of healthy individuals. Additionally, the expression levels of some probable co-receptors, including dipeptidyl peptidase 4 (DPP4), aminopeptidase N (AMPN), and glutamyl aminopeptidase (AMPE), were unchanged in the affected UC, CD, intestinal BD, and intestinal TB colon mucosa samples. In conclusion, gut inflammation associated with chronic colitis does not mediate a further increase in the cellular entry of SARS-CoV-2.
Keywords: COVID-19; Coronavirus; SARS-CoV-2; angiotensin converting enzyme 2; proteomics.
. 2020 Oct;61(10):891-894.
doi: 10.3349/ymj.2020.61.10.891.
Quantitative Proteomic Analysis of the Expression of SARS-CoV-2 Receptors in the Gut of Patients with Chronic Enterocolitis
Jihye Park[SUP] 1 2 [/SUP], Daeun Jeong[SUP] 3 4 [/SUP], Youn Wook Chung[SUP] 3 5 [/SUP], Da Hye Kim[SUP] 3 [/SUP], Jae Hee Cheon[SUP] 1 2 6 [/SUP], Ji Hwan Ryu[SUP] 3 7 [/SUP]
Affiliations
- PMID: 32975064
- DOI: 10.3349/ymj.2020.61.10.891
Abstract
The cellular entry of severe respiratory syndrome coronavirus-2 (SARS-CoV-2) is mediated by interaction with the human angiotensin-converting enzyme 2 (ACE2), a receptor that is expressed on both lung and intestinal epithelial cells. We performed a quantitative proteomic analysis to investigate the expression of possible receptors for SARS-CoV-2 in the intestinal mucosa of 23 patients with chronic colitis. ACE2 expression was low and remained unaltered in the gut of patients with ulcerative colitis (UC), Crohn's disease (CD), intestinal Behćet's disease (BD), and intestinal tuberculosis (TB), when compared with that of healthy individuals. Additionally, the expression levels of some probable co-receptors, including dipeptidyl peptidase 4 (DPP4), aminopeptidase N (AMPN), and glutamyl aminopeptidase (AMPE), were unchanged in the affected UC, CD, intestinal BD, and intestinal TB colon mucosa samples. In conclusion, gut inflammation associated with chronic colitis does not mediate a further increase in the cellular entry of SARS-CoV-2.
Keywords: COVID-19; Coronavirus; SARS-CoV-2; angiotensin converting enzyme 2; proteomics.