tetano
Editor, Senior Moderator
Bioorg Med Chem Lett. 2012 Apr 12. [Epub ahead of print]
Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses.
Dao TT, Dang TT, Nguyen PH, Kim E, Thuong PT, Oh WK.
Source
BK21 Project Team, College of Pharmacy, Chosun University, 375 Seosuk-dong, Dong-gu, Gwangju 501-759, Republic of Korea.
Abstract
The emergence of the H1N1 swine flu pandemic has the possibility to develop the occurrence of disaster- or drug-resistant viruses by additional reassortments in novel influenza A virus. In the course of an anti-influenza screening program for natural products, 10 xanthone derivatives (1-10) were isolated by bioassay-guided fractionation from the EtOAc-soluble extract of Polygala karensium. Compounds 1, 3, 5, 7, and 9 with a hydroxy group at C-1 showed strong inhibitory effects on neuraminidases from various influenza viral strains, H1N1, H9N2, novel H1N1 (WT), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. In addition, these compounds reduced the cytopathic effect of H1N1 swine influenza virus in MDCK cells. Our results suggest that xanthones from P. karensium may be useful in the prevention and treatment of disease by influenza viruses.
Copyright ? 2012 Elsevier Ltd. All rights reserved.
PMID:
22552195
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22552195
Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses.
Dao TT, Dang TT, Nguyen PH, Kim E, Thuong PT, Oh WK.
Source
BK21 Project Team, College of Pharmacy, Chosun University, 375 Seosuk-dong, Dong-gu, Gwangju 501-759, Republic of Korea.
Abstract
The emergence of the H1N1 swine flu pandemic has the possibility to develop the occurrence of disaster- or drug-resistant viruses by additional reassortments in novel influenza A virus. In the course of an anti-influenza screening program for natural products, 10 xanthone derivatives (1-10) were isolated by bioassay-guided fractionation from the EtOAc-soluble extract of Polygala karensium. Compounds 1, 3, 5, 7, and 9 with a hydroxy group at C-1 showed strong inhibitory effects on neuraminidases from various influenza viral strains, H1N1, H9N2, novel H1N1 (WT), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. In addition, these compounds reduced the cytopathic effect of H1N1 swine influenza virus in MDCK cells. Our results suggest that xanthones from P. karensium may be useful in the prevention and treatment of disease by influenza viruses.
Copyright ? 2012 Elsevier Ltd. All rights reserved.
PMID:
22552195
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22552195