tetano
Editor, Senior Moderator
World J Transplant
. 2022 Oct 18;12(10):325-330.
doi: 10.5500/wjt.v12.i10.325.
COVID-19 in a pregnant kidney transplant recipient - what we need to know: A case report
Roberta Angelico[SUP] 1 [/SUP], Maria Luisa Framarino-Dei-Malatesta[SUP] 2 [/SUP], Giuseppe Iaria[SUP] 3 [/SUP]
Affiliations
Abstract
Background: In the era of the coronavirus disease 2019 (COVID-19) pandemic, kidney tran splant recipients are more susceptible to severe acute respiratory syndrome co ronavirus (SARS-CoV-2) infection, developing severe morbidity and graft im pairment. Pregnant women are also more likely to develop severe COVID-19 di sease, causing pregnancy complications such as preterm births and acute kidney injury.
Case summary: Herein, we report the case of a pregnant woman with a third kidney tran splantation who developed COVID-19 disease. The reduction of immunosuppressive drugs and strict monitoring of trough blood levels were needed to avoid severe SARS-CoV-2-related complications, and permitted to continue a healthy pregnancy and maintain good graft function. In such a complex scenario, the con comitance of COVID-19-related morbidity, the risk of acute rejection in the hype rimmune recipient, graft dysfunction and pregnancy complications make the management of immunosuppression a very difficult task and clinicians must be aware.
Conclusion: Tailoring the immunosuppressive regimen is a key factor affecting both the graft outcome and pregnancy safety.
Keywords: COVID-19 disease; Case report; Complications; Immunosuppression; Kidney transplantation; Pregnancy; SARS-CoV-2 infection.
. 2022 Oct 18;12(10):325-330.
doi: 10.5500/wjt.v12.i10.325.
COVID-19 in a pregnant kidney transplant recipient - what we need to know: A case report
Roberta Angelico[SUP] 1 [/SUP], Maria Luisa Framarino-Dei-Malatesta[SUP] 2 [/SUP], Giuseppe Iaria[SUP] 3 [/SUP]
Affiliations
- PMID: 36313235
- PMCID: PMC9614586
- DOI: 10.5500/wjt.v12.i10.325
Abstract
Background: In the era of the coronavirus disease 2019 (COVID-19) pandemic, kidney tran splant recipients are more susceptible to severe acute respiratory syndrome co ronavirus (SARS-CoV-2) infection, developing severe morbidity and graft im pairment. Pregnant women are also more likely to develop severe COVID-19 di sease, causing pregnancy complications such as preterm births and acute kidney injury.
Case summary: Herein, we report the case of a pregnant woman with a third kidney tran splantation who developed COVID-19 disease. The reduction of immunosuppressive drugs and strict monitoring of trough blood levels were needed to avoid severe SARS-CoV-2-related complications, and permitted to continue a healthy pregnancy and maintain good graft function. In such a complex scenario, the con comitance of COVID-19-related morbidity, the risk of acute rejection in the hype rimmune recipient, graft dysfunction and pregnancy complications make the management of immunosuppression a very difficult task and clinicians must be aware.
Conclusion: Tailoring the immunosuppressive regimen is a key factor affecting both the graft outcome and pregnancy safety.
Keywords: COVID-19 disease; Case report; Complications; Immunosuppression; Kidney transplantation; Pregnancy; SARS-CoV-2 infection.