tetano
Editor, Senior Moderator
World J Gastrointest Endosc
. 2022 Mar 16;14(3):153-162.
doi: 10.4253/wjge.v14.i3.153.
SARS-CoV-2 in inflammatory bowel disease population: Antibodies, disease and correlation with therapy
Clara Benedetta Conti[SUP] 1 [/SUP], Elsa Mainardi[SUP] 2 [/SUP], Sara Soro[SUP] 3 [/SUP], Sophie Testa[SUP] 2 [/SUP], Annalisa De Silvestri[SUP] 4 [/SUP], Andrea Drago[SUP] 3 [/SUP], Fabrizio Cereatti[SUP] 3 [/SUP], Roberto Grassia[SUP] 3 [/SUP]
Affiliations
Abstract
Background: Guidelines recommend to cease inflammatory bowel disease (IBD) biologic therapy during coronavirus disease 2019 (COVID-19).
Aim: To investigate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody positivity in an IBD cohort, COVID-19 disease severity and to evaluate the correlation with clinical/therapeutic variables.
Methods: Prospective observational cohort study. IBD patients were tested for SARS-CoV-2 IgG. Data on COVID-19 disease, demographics/therapeutics and clinical features of the IBD population were collected. IgG ≥ 7 was set for SARS-CoV-2 antibody positivity. Throat swab was performed in cases of IgG positivity. Correlations between antibody positivity or COVID-19 symptoms and therapeutic/clinical data were assessed.
Results: In total, 103 IBD patients were enrolled. Among them, 18.4% had IgG ≥ 7. Multivariate analysis of antibody positivity correlated only with IBD treatment. For IgG ≥ 7, the odds ratio was 1.44 and 0.16 for azathioprine and mesalazine, respectively, vs biologic drugs (P = 0.0157 between them). COVID-19 related symptoms were reported in 63% of patients with IgG positivity. All but one patient with COVID-19 symptoms did not require ceasing IBD treatment or hospitalization. IBD treatment and body mass index correlated with COVID-19 disease development with symptoms.
Conclusion: The IBD population does not have a higher risk of severe COVID-19. The relative risk of having SARS-CoV-2 antibodies and symptoms was higher for patients taking azathioprine, then biologic therapy and lastly mesalazine. None of the patients under biologic therapy developed severe COVID-19.
Keywords: Biologic treatment; COVID-19; Inflammatory bowel disease; Inflammatory bowel disease therapy; SARS-CoV-2; SARS-CoV-2 antibody.
. 2022 Mar 16;14(3):153-162.
doi: 10.4253/wjge.v14.i3.153.
SARS-CoV-2 in inflammatory bowel disease population: Antibodies, disease and correlation with therapy
Clara Benedetta Conti[SUP] 1 [/SUP], Elsa Mainardi[SUP] 2 [/SUP], Sara Soro[SUP] 3 [/SUP], Sophie Testa[SUP] 2 [/SUP], Annalisa De Silvestri[SUP] 4 [/SUP], Andrea Drago[SUP] 3 [/SUP], Fabrizio Cereatti[SUP] 3 [/SUP], Roberto Grassia[SUP] 3 [/SUP]
Affiliations
- PMID: 35432745
- PMCID: PMC8984534
- DOI: 10.4253/wjge.v14.i3.153
Abstract
Background: Guidelines recommend to cease inflammatory bowel disease (IBD) biologic therapy during coronavirus disease 2019 (COVID-19).
Aim: To investigate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody positivity in an IBD cohort, COVID-19 disease severity and to evaluate the correlation with clinical/therapeutic variables.
Methods: Prospective observational cohort study. IBD patients were tested for SARS-CoV-2 IgG. Data on COVID-19 disease, demographics/therapeutics and clinical features of the IBD population were collected. IgG ≥ 7 was set for SARS-CoV-2 antibody positivity. Throat swab was performed in cases of IgG positivity. Correlations between antibody positivity or COVID-19 symptoms and therapeutic/clinical data were assessed.
Results: In total, 103 IBD patients were enrolled. Among them, 18.4% had IgG ≥ 7. Multivariate analysis of antibody positivity correlated only with IBD treatment. For IgG ≥ 7, the odds ratio was 1.44 and 0.16 for azathioprine and mesalazine, respectively, vs biologic drugs (P = 0.0157 between them). COVID-19 related symptoms were reported in 63% of patients with IgG positivity. All but one patient with COVID-19 symptoms did not require ceasing IBD treatment or hospitalization. IBD treatment and body mass index correlated with COVID-19 disease development with symptoms.
Conclusion: The IBD population does not have a higher risk of severe COVID-19. The relative risk of having SARS-CoV-2 antibodies and symptoms was higher for patients taking azathioprine, then biologic therapy and lastly mesalazine. None of the patients under biologic therapy developed severe COVID-19.
Keywords: Biologic treatment; COVID-19; Inflammatory bowel disease; Inflammatory bowel disease therapy; SARS-CoV-2; SARS-CoV-2 antibody.