tetano
Editor, Senior Moderator
World J Gastroenterol
. 2022 Dec 21;28(47):6716-6731.
doi: 10.3748/wjg.v28.i47.6716.
Liver injury in COVID-19: A minireview
Wen-Shu Hu[SUP] 1 2 [/SUP], Fang-Ying Jiang[SUP] 1 2 [/SUP], Wen Shu[SUP] 1 2 [/SUP], Rong Zhao[SUP] 1 2 [/SUP], Ji-Min Cao[SUP] 1 2 [/SUP], De-Ping Wang[SUP] 3 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19), caused by infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has escalated into a global tragedy afflicting human health, life, and social governance. Through the increasing depth of research and a better understanding of this disease, it has been ascertained that, in addition to the lungs, SARS-CoV-2 can also induce injuries to other organs including the liver. Liver injury is a common clinical manifestation of COVID-19, particularly in severe cases, and is often associated with a poorer prognosis and higher severity of COVID-19. This review focuses on the general existing information on liver injury caused by COVID-19, including risk factors and subpopulations of liver injury in COVID-19, the association between preexisting liver diseases and the severity of COVID-19, and the potential mechanisms by which SARS-CoV-2 affects the liver. This review may provide some useful information for the development of therapeutic and preventive strategies for COVID-19-associated liver injury.
Keywords: Angiotensin-converting enzyme 2; Chronic liver disease; Liver; SARS-CoV-2; Transmembrane serine protease 2.
. 2022 Dec 21;28(47):6716-6731.
doi: 10.3748/wjg.v28.i47.6716.
Liver injury in COVID-19: A minireview
Wen-Shu Hu[SUP] 1 2 [/SUP], Fang-Ying Jiang[SUP] 1 2 [/SUP], Wen Shu[SUP] 1 2 [/SUP], Rong Zhao[SUP] 1 2 [/SUP], Ji-Min Cao[SUP] 1 2 [/SUP], De-Ping Wang[SUP] 3 [/SUP]
Affiliations
- PMID: 36620342
- PMCID: PMC9813934
- DOI: 10.3748/wjg.v28.i47.6716
Abstract
Coronavirus disease 2019 (COVID-19), caused by infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has escalated into a global tragedy afflicting human health, life, and social governance. Through the increasing depth of research and a better understanding of this disease, it has been ascertained that, in addition to the lungs, SARS-CoV-2 can also induce injuries to other organs including the liver. Liver injury is a common clinical manifestation of COVID-19, particularly in severe cases, and is often associated with a poorer prognosis and higher severity of COVID-19. This review focuses on the general existing information on liver injury caused by COVID-19, including risk factors and subpopulations of liver injury in COVID-19, the association between preexisting liver diseases and the severity of COVID-19, and the potential mechanisms by which SARS-CoV-2 affects the liver. This review may provide some useful information for the development of therapeutic and preventive strategies for COVID-19-associated liver injury.
Keywords: Angiotensin-converting enzyme 2; Chronic liver disease; Liver; SARS-CoV-2; Transmembrane serine protease 2.