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World J Gastroenterol . Gastrointestinal microbiota: A predictor of COVID-19 severity?

tetano

Editor, Senior Moderator
World J Gastroenterol


. 2022 Dec 7;28(45):6328-6344.
doi: 10.3748/wjg.v28.i45.6328.
Gastrointestinal microbiota: A predictor of COVID-19 severity?


Maria Adriana Neag[SUP] 1 [/SUP], Damiana-Maria Vulturar[SUP] 2 [/SUP], Diana Gherman[SUP] 3 [/SUP], Codrin-Constantin Burlacu[SUP] 4 [/SUP], Doina Adina Todea[SUP] 5 [/SUP], Anca Dana Buzoianu[SUP] 1 [/SUP]



Affiliations

Abstract

Coronavirus disease 2019 (COVID-19), caused by a severe acute respiratory syndrome coronavirus 2 infection, has raised serious concerns worldwide over the past 3 years. The severity and clinical course of COVID-19 depends on many factors (e.g., associated comorbidities, age, etc) and may have various clinical and imaging findings, which raises management concerns. Gut microbiota composition is known to influence respiratory disease, and respiratory viral infection can also influence gut microbiota. Gut and lung microbiota and their relationship (gut-lung axis) can act as modulators of inflammation. Modulating the intestinal microbiota, by improving its composition and diversity through nutraceutical agents, can have a positive impact in the prophylaxis/treatment of COVID-19.

Keywords: COVID-19; Gut microbiota; Gut-lung axis; Nutraceuticals; Probiotics; Prognostic biomarkers.
 
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