tetano
Editor, Senior Moderator
World J Emerg Med
. 2021;12(4):293-298.
doi: 10.5847/wjem.j.1920-8642.2021.04.007.
Development of septic shock and prognostic assessment in critically ill patients with coronavirus disease outside Wuhan, China
Ren-Qi Yao[SUP] 1 2 [/SUP], Chao Ren[SUP] 1 2 [/SUP], Di Ren[SUP] 1 3 [/SUP], Jin-Xiu Li[SUP] 3 [/SUP], Ying Li[SUP] 1 [/SUP], Xue-Yan Liu[SUP] 4 [/SUP], Lei Huang[SUP] 5 [/SUP], Yong Liu[SUP] 6 [/SUP], Mian Peng[SUP] 7 [/SUP], Yong-Wen Feng[SUP] 1 [/SUP], Yong-Ming Yao[SUP] 1 2 [/SUP]
Affiliations
Abstract
Background: The study aims to illustrate the clinical characteristics and development of septic shock in intensive care unit (ICU) patients confirmed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and to perform a comprehensive analysis of the association between septic shock and clinical outcomes in critically ill patients with coronavirus disease (COVID-19).
Methods: Patients confirmed with SARS-CoV-2 infection, who were admitted to the ICU of the Third People's Hospital of Shenzhen from January 1 to February 7, 2020, were enrolled. Clinical characteristics and outcomes were compared between patients with and without septic shock.
Results: In this study, 35 critically ill patients with COVID-19 were included. Among them, the median age was 64 years (interquartile range [IQR] 59-67 years), and 10 (28.4%) patients were female. The median ICU length of stay was 16 days (IQR 8-23 days). Three (8.6%) patients died during hospitalization. Nine (25.7%) patients developed septic shock in the ICU, and these patients had a significantly higher incidence of organ dysfunction and a worse prognosis than patients without septic shock.
Conclusions: Septic shock is associated with a poor outcome in critically ill COVID-19 patients and is one of the hallmarks of the severity of patients receiving ICU care. A dysregulated immune response, uncontrolled inflammation, and coagulation disorders are strongly associated with the development and progression of COVID-19-related septic shock.
Keywords: Coronavirus disease; Immune response; Intensive care unit; Septic shock; Severe acute respiratory syndrome coronavirus 2.
. 2021;12(4):293-298.
doi: 10.5847/wjem.j.1920-8642.2021.04.007.
Development of septic shock and prognostic assessment in critically ill patients with coronavirus disease outside Wuhan, China
Ren-Qi Yao[SUP] 1 2 [/SUP], Chao Ren[SUP] 1 2 [/SUP], Di Ren[SUP] 1 3 [/SUP], Jin-Xiu Li[SUP] 3 [/SUP], Ying Li[SUP] 1 [/SUP], Xue-Yan Liu[SUP] 4 [/SUP], Lei Huang[SUP] 5 [/SUP], Yong Liu[SUP] 6 [/SUP], Mian Peng[SUP] 7 [/SUP], Yong-Wen Feng[SUP] 1 [/SUP], Yong-Ming Yao[SUP] 1 2 [/SUP]
Affiliations
- PMID: 34512826
- PMCID: PMC8390351
- DOI: 10.5847/wjem.j.1920-8642.2021.04.007
Abstract
Background: The study aims to illustrate the clinical characteristics and development of septic shock in intensive care unit (ICU) patients confirmed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and to perform a comprehensive analysis of the association between septic shock and clinical outcomes in critically ill patients with coronavirus disease (COVID-19).
Methods: Patients confirmed with SARS-CoV-2 infection, who were admitted to the ICU of the Third People's Hospital of Shenzhen from January 1 to February 7, 2020, were enrolled. Clinical characteristics and outcomes were compared between patients with and without septic shock.
Results: In this study, 35 critically ill patients with COVID-19 were included. Among them, the median age was 64 years (interquartile range [IQR] 59-67 years), and 10 (28.4%) patients were female. The median ICU length of stay was 16 days (IQR 8-23 days). Three (8.6%) patients died during hospitalization. Nine (25.7%) patients developed septic shock in the ICU, and these patients had a significantly higher incidence of organ dysfunction and a worse prognosis than patients without septic shock.
Conclusions: Septic shock is associated with a poor outcome in critically ill COVID-19 patients and is one of the hallmarks of the severity of patients receiving ICU care. A dysregulated immune response, uncontrolled inflammation, and coagulation disorders are strongly associated with the development and progression of COVID-19-related septic shock.
Keywords: Coronavirus disease; Immune response; Intensive care unit; Septic shock; Severe acute respiratory syndrome coronavirus 2.