tetano
Editor, Senior Moderator
World J Clin Cases
. 2023 Mar 26;11(9):1918-1929.
doi: 10.12998/wjcc.v11.i9.1918.
COVID-19 related liver injuries in pregnancy
Metodija Sekulovski[SUP] 1 2 [/SUP], Simona Bogdanova-Petrova[SUP] 3 4 [/SUP], Monika Peshevska-Sekulovska[SUP] 2 5 [/SUP], Tsvetelina Velikova[SUP] 2 6 [/SUP], Tsvetoslav Georgiev[SUP] 3 7 [/SUP]
Affiliations
Abstract
While severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) quickly spread across the globe, our understanding of its pathogenic mechanisms evolved. Importantly, coronavirus disease 2019 (COVID-19) is now considered a syndromic multisystem inflammatory disease involving not only the respiratory system but also the cardiovascular, excretory, nervous, musculoskeletal, and gastrointestinal systems. Moreover, a membrane-bound form of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2, is expressed on the surface of cholangiocytes and hepatocytes, suggesting the potential of COVID-19 to involve the liver. With the widespread distribution of SARS-CoV-2 throughout the population, infection during pregnancy is no longer a rare occurrence; however, little is known about the course of hepatic injuries and related outcomes in pregnant SARS-CoV-2-positive women. Thus, the understudied topic of COVID-related liver disease during pregnancy poses a great challenge for the consulting gynecologist and hepatologist. In this review, we aim to describe and summarize potential liver injuries in pregnant women with COVID-19.
Keywords: Angiotensin-converting enzyme 2 receptors; COVID-19; Liver injury; Pregnancy; SARS-CoV-2.
. 2023 Mar 26;11(9):1918-1929.
doi: 10.12998/wjcc.v11.i9.1918.
COVID-19 related liver injuries in pregnancy
Metodija Sekulovski[SUP] 1 2 [/SUP], Simona Bogdanova-Petrova[SUP] 3 4 [/SUP], Monika Peshevska-Sekulovska[SUP] 2 5 [/SUP], Tsvetelina Velikova[SUP] 2 6 [/SUP], Tsvetoslav Georgiev[SUP] 3 7 [/SUP]
Affiliations
- PMID: 36998958
- PMCID: PMC10044960
- DOI: 10.12998/wjcc.v11.i9.1918
Abstract
While severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) quickly spread across the globe, our understanding of its pathogenic mechanisms evolved. Importantly, coronavirus disease 2019 (COVID-19) is now considered a syndromic multisystem inflammatory disease involving not only the respiratory system but also the cardiovascular, excretory, nervous, musculoskeletal, and gastrointestinal systems. Moreover, a membrane-bound form of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2, is expressed on the surface of cholangiocytes and hepatocytes, suggesting the potential of COVID-19 to involve the liver. With the widespread distribution of SARS-CoV-2 throughout the population, infection during pregnancy is no longer a rare occurrence; however, little is known about the course of hepatic injuries and related outcomes in pregnant SARS-CoV-2-positive women. Thus, the understudied topic of COVID-related liver disease during pregnancy poses a great challenge for the consulting gynecologist and hepatologist. In this review, we aim to describe and summarize potential liver injuries in pregnant women with COVID-19.
Keywords: Angiotensin-converting enzyme 2 receptors; COVID-19; Liver injury; Pregnancy; SARS-CoV-2.