tetano
Editor, Senior Moderator
World J Clin Cases
. 2021 Jan 26;9(3):528-539.
doi: 10.12998/wjcc.v9.i3.528.
Clinical features and potential mechanism of coronavirus disease 2019-associated liver injury
Mei-Wen Han[SUP] 1 [/SUP], Ming Wang[SUP] 1 [/SUP], Meng-Ying Xu[SUP] 1 [/SUP], Wei-Peng Qi[SUP] 1 [/SUP], Peng Wang[SUP] 1 [/SUP], Dong Xi[SUP] 2 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has posed a serious threat to global public health security. With the increase in the number of confirmed cases globally, the World Health Organization has declared the outbreak of COVID-19 an international public health emergency. Despite atypical pneumonia as the primary symptom, liver dysfunction has also been observed in many clinical cases and is associated with the mortality risk in patients with COVID-19, like severe acute respiratory syndrome and Middle East respiratory syndrome. Here we will provide a schematic overview of the clinical characteristics and the possible mechanisms of liver injury caused by severe acute respiratory syndrome coronavirus 2 infection, which may provide help for optimizing the management of liver injury and reducing mortality in COVID-19 patients.
Keywords: COVID-19; Liver injury; Novel coronavirus; SARS-CoV-2.
. 2021 Jan 26;9(3):528-539.
doi: 10.12998/wjcc.v9.i3.528.
Clinical features and potential mechanism of coronavirus disease 2019-associated liver injury
Mei-Wen Han[SUP] 1 [/SUP], Ming Wang[SUP] 1 [/SUP], Meng-Ying Xu[SUP] 1 [/SUP], Wei-Peng Qi[SUP] 1 [/SUP], Peng Wang[SUP] 1 [/SUP], Dong Xi[SUP] 2 [/SUP]
Affiliations
- PMID: 33553391
- PMCID: PMC7829721
- DOI: 10.12998/wjcc.v9.i3.528
Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has posed a serious threat to global public health security. With the increase in the number of confirmed cases globally, the World Health Organization has declared the outbreak of COVID-19 an international public health emergency. Despite atypical pneumonia as the primary symptom, liver dysfunction has also been observed in many clinical cases and is associated with the mortality risk in patients with COVID-19, like severe acute respiratory syndrome and Middle East respiratory syndrome. Here we will provide a schematic overview of the clinical characteristics and the possible mechanisms of liver injury caused by severe acute respiratory syndrome coronavirus 2 infection, which may provide help for optimizing the management of liver injury and reducing mortality in COVID-19 patients.
Keywords: COVID-19; Liver injury; Novel coronavirus; SARS-CoV-2.