tetano
Editor, Senior Moderator
World J Clin Cases
. 2022 Nov 26;10(33):12268-12277.
doi: 10.12998/wjcc.v10.i33.12268.
Case mistaken for leukemia after mRNA COVID-19 vaccine administration: A case report
Seul Bi Lee[SUP] 1 [/SUP], Chi Young Park[SUP] 1 [/SUP], Sang-Gon Park[SUP] 1 [/SUP], Hee Jeong Lee[SUP] 2 [/SUP]
Affiliations
Abstract
Background: Following the global outbreak of coronavirus disease 2019 (COVID-19), unlike other vaccines, COVID-19 vaccines were developed and commercialized in a relatively short period of time. The large-scale administration of this vaccine in a short time-period led to various unexpected side effects, including severe cytopenia and thrombosis with thrombocytopenia syndrome. Despite many reports on adverse reactions, vaccination was necessary to prevent the spread of COVID-19; thus, it is essential to understand and discuss various cases of adverse reactions after vaccination.
Case summary: A 77-year-old woman was administered the second dose of Pfizer mRNA COVID-19 vaccine. After vaccination she experienced fever, myalgia, and weakness. Antibiotics were subsequently administered for several days, but there was no improvement in the symptoms. The patient showed severe thrombocytopenia and leukocytosis. Thoracic and abdominopelvic computed tomography showed no infection related findings, but splenomegaly and cirrhotic liver features were observed. A large number of immature cells were observed in the peripheral blood smear; thus, bone marrow examination was performed for acute leukemia. However, there were no abnormalities. The patient recovered after administration of hepatotoxins and transfusion treatment for cytopenia and was diagnosed with an adverse reaction to COVID-19 vaccination.
Conclusion: Adverse reactions of vaccination could be mistaken for hematologic malignancies including leukemia. We report a patient with leukocytosis following COVID-19 vaccination.
Keywords: Adverse reaction; COVID-19; Case report; Leukocytosis; Vaccine; mRNA.
. 2022 Nov 26;10(33):12268-12277.
doi: 10.12998/wjcc.v10.i33.12268.
Case mistaken for leukemia after mRNA COVID-19 vaccine administration: A case report
Seul Bi Lee[SUP] 1 [/SUP], Chi Young Park[SUP] 1 [/SUP], Sang-Gon Park[SUP] 1 [/SUP], Hee Jeong Lee[SUP] 2 [/SUP]
Affiliations
- PMID: 36483810
- PMCID: PMC9724544
- DOI: 10.12998/wjcc.v10.i33.12268
Abstract
Background: Following the global outbreak of coronavirus disease 2019 (COVID-19), unlike other vaccines, COVID-19 vaccines were developed and commercialized in a relatively short period of time. The large-scale administration of this vaccine in a short time-period led to various unexpected side effects, including severe cytopenia and thrombosis with thrombocytopenia syndrome. Despite many reports on adverse reactions, vaccination was necessary to prevent the spread of COVID-19; thus, it is essential to understand and discuss various cases of adverse reactions after vaccination.
Case summary: A 77-year-old woman was administered the second dose of Pfizer mRNA COVID-19 vaccine. After vaccination she experienced fever, myalgia, and weakness. Antibiotics were subsequently administered for several days, but there was no improvement in the symptoms. The patient showed severe thrombocytopenia and leukocytosis. Thoracic and abdominopelvic computed tomography showed no infection related findings, but splenomegaly and cirrhotic liver features were observed. A large number of immature cells were observed in the peripheral blood smear; thus, bone marrow examination was performed for acute leukemia. However, there were no abnormalities. The patient recovered after administration of hepatotoxins and transfusion treatment for cytopenia and was diagnosed with an adverse reaction to COVID-19 vaccination.
Conclusion: Adverse reactions of vaccination could be mistaken for hematologic malignancies including leukemia. We report a patient with leukocytosis following COVID-19 vaccination.
Keywords: Adverse reaction; COVID-19; Case report; Leukocytosis; Vaccine; mRNA.