Women Using IUDs at Greater Risk for Rheumatoid Arthritis
By Rachel Lutz | November 19, 2014
...
The researchers observed 976 women without an RA diagnosis, but with a first-degree relative with RA and were therefore classified as an increased risk for future RA based on family history....
...
The researchers concluded that women using an IUD had statistically significantly increased risk for anti-CCP positivity. Women who used oral contraceptive pills (OCPs) were at a decreased risk of anti-CCP positivity, either currently or in the past. There was no link found between anti-CCP positivity and pregnancy or breastfeeding...
...
?While the mechanisms that link contraceptive factors to ACPA generation are unknown, unlike OCPs, IUDs have been shown to generate endometrial inflammatory responses,? the authors conclude. ?Therefore, the association of IUD use and ACPA suggest that IUD-induced endometrial inflammation may be a potential mucosal trigger of RA-related autoantibodies.? - See more at:
http://www.hcplive.com/conferences/...or-Rheumatoid-Arthritis-#sthash.UTCWzIdN.dpuf
