tetano
Editor, Senior Moderator
Wien Klin Wochenschr
. 2023 Apr 24.
doi: 10.1007/s00508-023-02180-w. Online ahead of print.
Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients : A single center registry-based retrospective cohort study
Grgur Salai[SUP] 1 [/SUP], Hrvoje Vrazic[SUP] 2 3 [/SUP], Ivona Kovacevic[SUP] 1 [/SUP], Linda Malnar Janes[SUP] 1 [/SUP], Ivan Marasovic[SUP] 1 [/SUP], Darjan Ranilovic[SUP] 1 [/SUP], Damir Vukoja[SUP] 1 [/SUP], Marina Zelenika Margeta[SUP] 1 [/SUP], Ivana Huljev-Sipos[SUP] 1 [/SUP], Kristina Lalic[SUP] 1 [/SUP], Marko Spoljaric[SUP] 1 [/SUP], Jasna Tekavec-Trkanjec[SUP] 1 [/SUP], Mirna Vergles[SUP] 1 [/SUP], Marko Lucijanic[SUP] 4 5 [/SUP], Ivica Luksic[SUP] 6 5 [/SUP], Divo Ljubicic[SUP] 7 8 [/SUP]
Affiliations
Abstract
Introduction: The impact of asthma and chronic obstructive pulmonary disease (COPD) in the setting of severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) infection is not clearly defined. Blood eosinophil count is a standard diagnostic test which, according to the previously published literature, might have a potential prognostic role on mortality in patients with SARS-CoV‑2 infection.
Aim: To investigate the potential prognostic value of peripheral blood eosinophil count on all-cause mortality of patients hospitalized with SARS-CoV‑2 infection, as well as to assess the impact of asthma or COPD premorbidity on all-cause mortality.
Material and methods: We conducted a retrospective registry-based cohort study. Survival analysis was performed by employing the Cox proportional hazards regression model at 30 days of follow-up. Prognostic value of eosinophil count on all-cause mortality was assessed using receiver-operating characteristic (ROC) curve analysis.
Results: A total of 5653 participants were included in the study. Our model did not reveal that pre-existing asthma or COPD is a statistically significant covariate for all-cause mortality but, indicated that higher eosinophil count at admission might have a protective effect (hazard ratio, HR 0.13 (95% confidence interval, CI 0.06-0.27), p = 0.0001). ROC curve analysis indicates cut-off value of 20 cells/mm[SUP]3[/SUP] (81% specificity; 30.9% sensitivity).
Conclusion: Our results indicate that eosinophil count at hospital admission might have a potential prognostic role for all-cause mortality at 30 days of follow-up; however this was not demonstrated for pre-existing obstructive lung diseases.
Keywords: Asthma; COVID-19; Chronic obstructive pulmonary disease; Eosinophils; Retrospective cohort study.
. 2023 Apr 24.
doi: 10.1007/s00508-023-02180-w. Online ahead of print.
Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients : A single center registry-based retrospective cohort study
Grgur Salai[SUP] 1 [/SUP], Hrvoje Vrazic[SUP] 2 3 [/SUP], Ivona Kovacevic[SUP] 1 [/SUP], Linda Malnar Janes[SUP] 1 [/SUP], Ivan Marasovic[SUP] 1 [/SUP], Darjan Ranilovic[SUP] 1 [/SUP], Damir Vukoja[SUP] 1 [/SUP], Marina Zelenika Margeta[SUP] 1 [/SUP], Ivana Huljev-Sipos[SUP] 1 [/SUP], Kristina Lalic[SUP] 1 [/SUP], Marko Spoljaric[SUP] 1 [/SUP], Jasna Tekavec-Trkanjec[SUP] 1 [/SUP], Mirna Vergles[SUP] 1 [/SUP], Marko Lucijanic[SUP] 4 5 [/SUP], Ivica Luksic[SUP] 6 5 [/SUP], Divo Ljubicic[SUP] 7 8 [/SUP]
Affiliations
- PMID: 37093279
- DOI: 10.1007/s00508-023-02180-w
Abstract
Introduction: The impact of asthma and chronic obstructive pulmonary disease (COPD) in the setting of severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) infection is not clearly defined. Blood eosinophil count is a standard diagnostic test which, according to the previously published literature, might have a potential prognostic role on mortality in patients with SARS-CoV‑2 infection.
Aim: To investigate the potential prognostic value of peripheral blood eosinophil count on all-cause mortality of patients hospitalized with SARS-CoV‑2 infection, as well as to assess the impact of asthma or COPD premorbidity on all-cause mortality.
Material and methods: We conducted a retrospective registry-based cohort study. Survival analysis was performed by employing the Cox proportional hazards regression model at 30 days of follow-up. Prognostic value of eosinophil count on all-cause mortality was assessed using receiver-operating characteristic (ROC) curve analysis.
Results: A total of 5653 participants were included in the study. Our model did not reveal that pre-existing asthma or COPD is a statistically significant covariate for all-cause mortality but, indicated that higher eosinophil count at admission might have a protective effect (hazard ratio, HR 0.13 (95% confidence interval, CI 0.06-0.27), p = 0.0001). ROC curve analysis indicates cut-off value of 20 cells/mm[SUP]3[/SUP] (81% specificity; 30.9% sensitivity).
Conclusion: Our results indicate that eosinophil count at hospital admission might have a potential prognostic role for all-cause mortality at 30 days of follow-up; however this was not demonstrated for pre-existing obstructive lung diseases.
Keywords: Asthma; COVID-19; Chronic obstructive pulmonary disease; Eosinophils; Retrospective cohort study.