tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2016 Jun 24. doi: 10.1111/irv.12401. [Epub ahead of print]
[h=1]Whole-genome analysis of influenza A(H1N1)pdm09 viruses isolated in Uganda from 2009 to 2011.[/h] Byarugaba DK[SUP]1,[/SUP][SUP]2[/SUP], Erima B[SUP]2[/SUP], Millard M[SUP]2[/SUP], Kibuuka H[SUP]2[/SUP], Lkwago L[SUP]3[/SUP], Bwogi J[SUP]4[/SUP], Mimbe D[SUP]2[/SUP], Kiconco JB[SUP]2[/SUP], Tugume T[SUP]2[/SUP], Mworozi EA[SUP]5[/SUP], Turner J[SUP]6[/SUP], Mckenzie PP[SUP]6[/SUP], Webby RR[SUP]6[/SUP], Webster RG[SUP]6[/SUP], Foret C[SUP]7[/SUP], Ducatez MF[SUP]6,[/SUP][SUP]7[/SUP], Coldren R[SUP]8[/SUP], Wabwire-Mangen F[SUP]2[/SUP], Krauss S[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We report a whole-genome analysis of 19 influenza A(H1N1)pdm09 isolates from four Ugandan hospitals between 2009 and 2011. The isolates differed from the vaccine strain A/California/07/2009 by 3 amino acid substitutions P100S, S220T AND I338V in the hemagglutinin and by 2 amino acid substitutions V106I and N248D in the neuraminidase with consistent mutations in all gene segments distinguishing isolates from the 2009/2010 and 2010/2011 seasons. Phylogenetic analysis showed low genetic evolution, with genetic distances of 0%-1.3% and 0.1%-1.6% for HA and NA genes respectively. The amino acid substitutions did not lead to antigenic differences from the reference strains. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza A(H1N1)pdm09; Uganda; whole-genome sequencing
PMID: 27339410 DOI: 10.1111/irv.12401
[PubMed - as supplied by publisher] Free full text
[h=1]Whole-genome analysis of influenza A(H1N1)pdm09 viruses isolated in Uganda from 2009 to 2011.[/h] Byarugaba DK[SUP]1,[/SUP][SUP]2[/SUP], Erima B[SUP]2[/SUP], Millard M[SUP]2[/SUP], Kibuuka H[SUP]2[/SUP], Lkwago L[SUP]3[/SUP], Bwogi J[SUP]4[/SUP], Mimbe D[SUP]2[/SUP], Kiconco JB[SUP]2[/SUP], Tugume T[SUP]2[/SUP], Mworozi EA[SUP]5[/SUP], Turner J[SUP]6[/SUP], Mckenzie PP[SUP]6[/SUP], Webby RR[SUP]6[/SUP], Webster RG[SUP]6[/SUP], Foret C[SUP]7[/SUP], Ducatez MF[SUP]6,[/SUP][SUP]7[/SUP], Coldren R[SUP]8[/SUP], Wabwire-Mangen F[SUP]2[/SUP], Krauss S[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We report a whole-genome analysis of 19 influenza A(H1N1)pdm09 isolates from four Ugandan hospitals between 2009 and 2011. The isolates differed from the vaccine strain A/California/07/2009 by 3 amino acid substitutions P100S, S220T AND I338V in the hemagglutinin and by 2 amino acid substitutions V106I and N248D in the neuraminidase with consistent mutations in all gene segments distinguishing isolates from the 2009/2010 and 2010/2011 seasons. Phylogenetic analysis showed low genetic evolution, with genetic distances of 0%-1.3% and 0.1%-1.6% for HA and NA genes respectively. The amino acid substitutions did not lead to antigenic differences from the reference strains. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza A(H1N1)pdm09; Uganda; whole-genome sequencing
PMID: 27339410 DOI: 10.1111/irv.12401
[PubMed - as supplied by publisher] Free full text