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WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

I said:
It's password protected. It appears no part of it can be cut and pasted or copied. It may be printed.

What exactly does "permissions password" mean?
Click to expand...
And you said:
It is on this thread and is not password protected
Click to expand...
.

So I showed that it is password protected.

Actually, in all the .pdf docs I've come across that I've cut and pasted from, I've only found 2 so far that were protected to the point I can only view or print. And this is one of them.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

Thanks Dr. Niman. I refreshed my memory with your commentary from August. And today I read that next years seasonal vaccine will include all Brisbane strains.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

mixin, I just clicked on Dr. Nimans link, and it opened for me in Adobe.

ETA: I see what you are saying. No. You can not copy and paste from it. Unfortunately.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

Commonground said:
Thanks Dr. Niman. I refreshed my memory with your commentary from August. And today I read that next years seasonal vaccine will include all Brisbane strains.
Click to expand...
Brisbane/59 won't do much. H1N1 is already vaccine resistant.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

Commonground said:
Thanks Dr. Niman. I refreshed my memory with your commentary from August. And today I read that next years seasonal vaccine will include all Brisbane strains.
Click to expand...

Brisbane/59 won't do much. H1N1 is already vaccine resistant.

You're right....
164.gif
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

what ?
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

The Panasonic representative in Japan told me the reason for their decision was due to pandemic concerns. He also told me that they had no special knowledge about an influenza pandemic that had influenced their repatriation schedule.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

gsgs said:
what ?
Click to expand...
Multiple countries have reported vaccine resistance for H1N1 including Taiwan, Japan, and Italy. In the US, CDC has issued a disclaimer.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

The HA and NA sequences of A/chicken/Vietnam/NCVD-016/2008 have been released at GISAID.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

niman said:
Multiple countries have reported vaccine resistance for H1N1 including Taiwan, Japan, and Italy. In the US, CDC has issued a disclaimer.
Click to expand...


does WHO or CDC or Solvay or CIDRAP or ECDC or another similar source say so ?
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

gsgs said:
does WHO or CDC or Solvay or CIDRAP or ECDC or another similar source say so ?
Click to expand...
I am not sure what a "similar source" is
The source for Taiwain was the CDC in Taiwan.
The source for Japan was the NIH in Japan
The source for the US was the CDC DISCLAIMER.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

China has submitted a new HA sequence to GenBank for A/chicken/Shanxi/2/2006 which has the 3 BP deletion in clade 7 from Hunan as well multple clade 2.2 isolates in Egypt, increasing the liklihood that the withheld human sequences in China are clade 7 and have the 3 BP deletion (the S at position 129).

The 3 BP deletion provides strong evidence for H5N1 evolution via recombination.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

hmm, same deletion as that what happened in human H1N1 1995 ?

kalign aligns it to the same positions
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

gsgs said:
hmm, same deletion as that what happened in human H1N1 1995 ?

kalign aligns it to the same positions
Click to expand...
Aligning H1 with H5 can be tricky. Which H1 sequences have the deletion?
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

gsgs said:
hmm, same deletion as that what happened in human H1N1 1995 ?

kalign aligns it to the same positions
Click to expand...
I looked harder at other serotypes and found two low path H5N2 sequences, but didn't see H1N1 from 1995. H2 is missing an amino acid in this area, but H2 doesn't have much homology with H5 in this region.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

see this paper about the K134 deletion in H1N1
http://vir.sgmjournals.org/cgi/content/full/88/12/3209
maybe the "same" position as far as one can compare H5 and H1

> reinsertion of K134 revealed the requirement of a compatible neuraminidase

also N1


these deletions are rare

the common ancestor of H5 and H1 is presumably more than ~400 years ago
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

niman said:
Commentary

http://www.recombinomics.com/News/02240901/H5N1_Shanxi_Changes.html
Click to expand...

Commentary

Shanxi H5N1 Clade 7 Changes Raise Pandemic Concerns

Recombinomics Commentary 20:31
February 24, 2009


China's National Avian Infleunza Reference Laboratory at Harbin have deposited two new gene sequences (HA and NS) for the clade 7 isolate, A/chicken/Shanxi/2/2006, from the 2006 outbreak in Shanxi. In addition to changes in several single nucleotide polymorphisms, the new HA sequence has the 3 BP deletion that is in two other clade 7 sequences from Hunan, A/chicken/Hunan/2246/2006 and A/chicken/Hunan/2292/2006. This deletion is also in 12 clade 2.2 sequences from Egypt, including human isolates from the 2006/2007 season as well as the 2007/2008. The sharing of the identical 3 BP deletion by isolates from two distinct H5N1 clades provides compelling evidence for acquisition via homologous recombination. Moreover, sequences with the 3 BP deletion, as well as other sequences from Egypt, including sequences from vaccine resistant isolates share additional polymorphisms with the Shanxi sequence.

The new interest in the Shanxi sequence by the National Labs at Harbin adds to the circumstantial evidence that most or all of the six confirmed cases not discussed in the recent WHO report on H5N1 vaccine targets are clade 7, which was also reported for the Jiangsu poultry outbreak in China at the end of the year.

Although the WHO report did not discuss clade 7 in China, the variation in clade 7 in Vietnam was discussed because of the low cross reactivity between 2008 clade 7 isolates. The reduced cross reactivity between clade 7 isolates from the same country and year signals rapid evolution of clade 7, and the limited cross reactivity with antisera directed against clade 1 or clade 2 increases concerns.

The concerns regarding the rapid evolution of clade 7 in Vietnam are increased by the failure of WHO to discuss the six confirmed cases in China, including the Beijing isolate. A/Beijing/1/2009, which was from a fatal infection that began just after the clade 7 outbreak in Jiangsu.

Moreover, the sharing of polymorphisms between vaccine resistant clade 7 in China, and vaccine resistant clade 2.2 in Egypt raises concerns that these polymorphisms are being exported from China via migratory birds, contributing to worldwide vaccine failure.

Release of the 2009 human H5N1 sequences in China, Vietnam, and Egypt would be useful.

.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

rapid evolution of clade 7
Click to expand...

Why would this clade evolve more rapidly than others? If it's evolutionary fitness, what are the specifics?

.
 
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