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WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

Giuseppe

Giuseppe

Emeritus
WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

[Original Protected PDF Document at: LINK. EDITED.]
[These images are from the above document and are somewhat modified in order to magnify or reduce size and improve readability. IOH.]


<table style="width: auto;"><tbody><tr><td></td></tr><tr><td style="font-family: arial,sans-serif; font-size: 11px; text-align: right;">From TABLES</td></tr></tbody></table>

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<table style="width: auto;"><tbody><tr><td></td></tr><tr><td style="font-family: arial,sans-serif; font-size: 11px; text-align: right;">From TABLES</td></tr></tbody></table>

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Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

So this document specifically says Clade 7 has been found in birds in Asia.
[it's in the previous post]

I think it is in Vietnam.

"It says "Antigenic diversity is also present within clade 7 and viruses such as A/chicken/Vietnam/NCDV-03/2008 show reduced reactivity with antisera to the clade 7 reference strain A/chicken/Vietnam/NCDV-016/2008."

And the vaccine isn't working.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

protected non-text format ?
why ?
is it public or not ? copyrighted by WHO-->UNO ?
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

Commonground said:
So this document specifically says Clade 7 has been found in birds in Asia.
[it's in the previous post]

I think it is in Vietnam.

"It says "Antigenic diversity is also present within clade 7 and viruses such as A/chicken/Vietnam/NCDV-03/2008 show reduced reactivity with antisera to the clade 7 reference strain A/chicken/Vietnam/NCDV-016/2008."

And the vaccine isn't working.
Click to expand...
Noticably absent is any discussion of A/Beijing/1/2009, which was the first of the recent series.
The witholding of that data (and the other 5 human isolates) once again points toward clade 7.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

The China story is pretty obvious to those paying attention. The first case was in Beijing. She (19F) developed symptoms on Dec 24 and died Jan 5. Thus, A/Beijing/1/2009 was isolated in early January and was widely reported. It did not have reassortment with human genes, indicdating ALL EIGHT gene segements had been sequenced. Only HA would be required for the phylogenetic tree WHO just published, and the sequence or placement on the tree would CLEARLY show it was clade 7.

However, only two of the eight isolates are on the tree. These are the more common clade 2.3.4, which accounted for almost all prior human cases in China, and clade 2.3.2 which was said to be the "first" human case, but anyone paying attention knew that the culler in South Korea who was H5 PCR confirmed was infected with clade 2.3.2, which is what caused the outbreaks in South Korea, Japan, and Russia (and is carried by wild birds between Hong Kong (where it appeared in early 2008 and early 2009 as well as whooper swans in Japan in the spring of 2008).

The clade 2.3.2 was from a case who developed symptoms on Jan 19 and died Jan 26, so China had no problem getting this sequence into the WHO tree, but the only other isolate was clade 2.3.4.

Thus, it is likely that 6 of the 8 human cases in China were clade 7, but only data on clade 2.3.2 and 2.3.4 were released.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

mixin said:
It's password protected. It appears no part of it can be cut and pasted or copied. It may be printed.

What exactly does "permissions password" mean?
Click to expand...
It is on this thread and is not password protected. Anyone can download and save the file.
 
Last edited by a moderator:
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

Thank you Dr. Niman to take time to explain what you observe. I cannot read an order. I appreciate when those which are specialized take time to popularize information for a broader audience.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

niman said:
It is on this thread and is not password protected. Anyone can download and save the file.
Click to expand...

Have you looked at your link? I'd cut and paste the password protection info for you, except it won't let me.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

mixin said:
Have you looked at your link? I'd cut and paste the password protection info for you, except it won't let me.
Click to expand...
I've downloaded and saved the document. No password required.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

Muscade said:
Thank you Dr. Niman to take time to explain what you observe. I cannot read an order. I appreciate when those which are specialized take time to popularize information for a broader audience.
Click to expand...
The trees really are not that hard. Each node or branch represents a new clade or sub-clade as indicated on the right of the figure.

The individual isolates are named with species (if no species is listed it is human), followed by the location, sample number, and year listed.

Sample numbers are usually assigned sequentially (sometimes for each location) and start over for the season or year.

A/Hunan/1/2009 was the first isolate in 2009 in Hunan and would have been from the 16M who died January 20. A/Hunan/2/2009 was the 2 year who recovered. A/Hunan/3/2009 would be the 21F who also recovered, but developed symptoms Jan23 (and is the only isolate that might not have been characterized in time for the WHO publication). AGuangxi/1/2009 was the first isoalte from Guangxi, which was a case that died Jan26 (most isolates are from samples collected near the time of death when viral load is highest).

A/Beijing/1/2009 was from the 19F who developed stmptoms on Dec 24, 2008 and died January 5, 2009. All of these dates are from WHO situation updates for China.

However, A/Beijing/1/2009 was also widely discussed in media reports based on MOH press conferences, which indicated there was no reassortment and differences with other isolates in China represented small variations.

However, China, like WHO, would not give the clade number and the six omitted cases in the WHO discussion are GLARING.

Clade 7 is a concern because there is no pandemic vaccine, and it is resistant to most poultry vaccines. The released sequneces from poultry in Shanxi and Hunan also have MANY receptor binding domain changes, which is why it is a cause for concern and why WHO and China won't talk about the clade in multiple human cases, and why no sequences are being released.

Panasonic knows what it is doing. Reading between the lines is VERY easy (especially for those who can read a sequence, even when it is withheld).
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

Has Clade 7 been in Vietnam since 2008? And if so, why aren't you just as concerned about Vietnam, as you are about China?

Why haven't we had more infected people in Vietnam?
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

niman said:
I've downloaded and saved the document. No password required.
Click to expand...

Yes, you can save it for viewing and you can print it; but nothing else.

I have not found any way to copy and paste any part of a locked .pdf doc.

Here, I typed the info from their locked security icon.

Security settings: this document has an open password or a modify password
You cannot edit or copy this document

All contents of this document are encrypted and search engines cannot access this document's metadata.

Permission Details: Password Security:

Document Open Password: No
Permissions Password: Yes
Printing: High Resolution
Changing the Document: Not Allowed
Commenting: Not Allowed
Form Field Fill-in or Signing: Not Allowed
Document Assembly: Not Allowed
Content Copying: Not Allowed
Content Accessibility Enabled: Not Allowed
Page Extraction: Not Allowed
Encryption Level: 128-bit RC4

Printing: Allowed
Content Copying for Accessibility: Allowed
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

Commonground said:
Has Clade 7 been in Vietnam since 2008? And if so, why aren't you just as concerned about Vietnam, as you are about China?

Why haven't we had more infected people in Vietnam?
Click to expand...
The cluster in Vietnam was probably clade 7. China has a lot more people and poultry and, as is obvious in the WHO report, they are withholding the clade 7 info, so the sudden halt in reported cases (and failure to report H5N1 infected poultry) send strong signals.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

mixin said:
Yes, you can save it for viewing and you can print it; but nothing else.

I have not found any way to copy and paste any part of a locked .pdf doc.

Here, I typed the info from their locked security icon.

Security settings: this document has an open password or a modify password
You cannot edit or copy this document

All contents of this document are encrypted and search engines cannot access this document's metadata.

Permission Details: Password Security:

Document Open Password: No
Permissions Password: Yes
Printing: High Resolution
Changing the Document: Not Allowed
Commenting: Not Allowed
Form Field Fill-in or Signing: Not Allowed
Document Assembly: Not Allowed
Content Copying: Not Allowed
Content Accessibility Enabled: Not Allowed
Page Extraction: Not Allowed
Encryption Level: 128-bit RC4

Printing: Allowed
Content Copying for Accessibility: Allowed
Click to expand...

It can be opened, viewed, and saved. Most public documents have protection to avoid editing.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

I said:
It's password protected. It appears no part of it can be cut and pasted or copied. It may be printed.

What exactly does "permissions password" mean?
Click to expand...
And you said:
It is on this thread and is not password protected
Click to expand...
.

So I showed that it is password protected.

Actually, in all the .pdf docs I've come across that I've cut and pasted from, I've only found 2 so far that were protected to the point I can only view or print. And this is one of them.
 
Last edited by a moderator:
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

Thanks Dr. Niman. I refreshed my memory with your commentary from August. And today I read that next years seasonal vaccine will include all Brisbane strains.
 
Re: WHO. Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in human vaccines (Feb. 2009)

mixin, I just clicked on Dr. Nimans link, and it opened for me in Adobe.

ETA: I see what you are saying. No. You can not copy and paste from it. Unfortunately.
 
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