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Webster Warns Variant of swine influenza specifically attack the lungs with young children "even if the virus mutates, the vaccine and drugs are stil

Treyfish

Moderator
Variant of swine influenza specifically attack the lung with young children
2009-12-05
p.jpg


Has emerged the world's 40 drug-resistant swine influenza viruses, University of Hong Kong Li Ka-shing (related) such as Harvard University School of Medicine in conjunction with the United States to conduct the study.

(Roundup) (Sing Tao Daily reported) the number of pick-up in swine influenza infection, there are visits to Hong Kong virus, experts believe that Hong Kong may have entered the swine flu, the second wave, although the epidemic is expected to moderate, but found the world's emerging 200 Nianer were variants of swine influenza virus, lethal for children under ten or stronger, the virus will go into the lungs; Experts urge people to fight swine influenza vaccine as soon as possible, but also proposes that the Government will be free for children vaccination of swine influenza vaccine policy and consists of six extended to the age of ten or below for children.

Visit to the United States is Hong Kong's Research Hospital in St. Zhu De, Department of infectious diseases, virologists Weishi Bo (Webster), Professor said that the U.S. is now the second wave of swine influenza in the fall period, but since the outbreak of swine influenza throughout the country since there are eight million 16 children under the age of infection, 36000 were hospitalized, 540 children died from swine flu, compared with an annual average of only 80 children die from seasonal influenza, a difference of nearly seven times the number of deaths.

Weishi Bo also said that Norway discovered variant of swine flu, the global Nianer 200 cases have been found, because of its viral proteins, the regional variations in the H22, so that variants of swine influenza on children under ten or highly lethal, the virus can penetrate the lungs in patients with , resulting in two deaths in Norway, the deceased black lung, such as coke.

He was worried that the United States when the third wave of swine flu, would be led by a variant of swine influenza virus, when more children will be subject to attack, but also worried that swine influenza virus and up to five percent of the deadly H5N1 bird flu virus reshuffle, will be more lethal severe.

Weishi Bo added that the U.S. is now a trial drug Peramivir, intensive care for children with severe swine influenza treatment, the drug directly into the blood vessels, a considerable effect, but each time you use are subject to prior approval of the U.S. Centers for Disease Control and Prevention (CDC) approval.

Hong Kong people infected with swine flu, the number rebounded Wei Shibo that, there are likely to have entered the second wave of swine flu, it is estimated that the overall epidemic in other countries or regions are similar, are considered moderate.

As concerns the virus variants influence, he worried that children under ten or infections as severe as with the United States, so that Hong Kong free of charge for children under six plan to fight flu shot, might consider extending to the old, "even if the virus mutates, the vaccine and drugs are still effective. "

In addition, the global drug resistance has emerged 40 of swine influenza virus, in conjunction with the University of Hong Kong Li Ka Shing School of Medicine at Harvard University and other mathematical model of the relevant research shows that in an influenza pandemic, the early use of a single antiviral drugs, such as Tamiflu, infection rates of up to Qi Cheng.

However, if at an early stage (community population, lower than the percentage rate of infection 1:00), restraint and medication, only the use of Relenza or amantadine, or mix them and Tamiflu can reduce the resistance, and also would reduce the transmission rate less than 5 into 7.

Participated in the study of Hong Kong School of Public Health assistant professor of beard-kei said: "This response is the nature of the insurance, but the Government has implemented, is still considering a number of factors, it is necessary to see the public would accept.":tiphat:http://news.sina.com.hk/cgi-bin/nw/show.cgi/2/1/1/1349916/1.html
 
Re: Webster Warns Variant of swine influenza specifically attack the lungs with young children

Re: Webster Warns Variant of swine influenza specifically attack the lungs with young children

2009-11-30

Norway Provides Distinct 225G Coding from Lung in September Male Fatality

A/Norway/3206-3 HA and NA, sampled on 2009-09-01 from the post-mortem lung of a male fatality imports a new 225G to Norway.

Only CatNS2001 and CatNS2008 from early August carry this variant Glycine coding at amino acid 225 that is seen as T717A, GGt->GGa. Neither of the cross segment pair, HA syn413K or NA syn407V, appears in this sample. Norway3206 carries a second HA polymorphism at 140S, a change found only 3 times within the reservoir, but found elsewhere in 1918 specimens, H5N1 Avian, Seasonal 2007, 2008, 2009 and the red-winged tinamou from 2008.

The Norway NA shows one residue of interest at syn291V, a change that is found in 102 sequences including TamiFlu Resistant HK2369, Almati01, Tomsk01, Poland and with deep penetration through Italy and Catalonia.

Two different codings for Glycine at residue 225 at this early stage of the pandemic demonstrates an ability within ΣPF11 for an individual strain to adapt quickly.
 
Re: Webster Warns Variant of swine influenza specifically attack the lungs with young children "even if the virus mutates, the vaccine and drugs are still effective. "

can someone tell me what Dr Webster book is he promoting please


FRONT....

BioMedical RESEARCH

HKU (Hong Kong University?)

2009
 
Last edited by a moderator:
Re: Webster Warns Variant of swine influenza specifically attack the lungs with young children "even if the virus mutates, the vaccine and drugs are still effective. "

Thank you JJackson
 
Re: Webster Warns Variant of swine influenza specifically attack the lungs with young children "even if the virus mutates, the vaccine and drugs are still effective. "

If I understand properly our Task becomes ''Making sense of Communications''.

IMHO it transcend Sandman and Lanard.

It has now become imperative.

Any opinions from Flu Trackers Team?
 
Re: Webster Warns Variant of swine influenza specifically attack the lungs with young children "even if the virus mutates, the vaccine and drugs are still effective. "

225G Preliminary Worldwide Tracking & Evaluation

http://www.flutrackers.com/forum/showthread.php?t=134015


Norway - H1N1 "Mutation" Announced by Health Department

http://www.flutrackers.com/forum/showthread.php?t=133897


Tamiflu Resistance in A/H1N1 flu - Historical Compilation of News


http://www.flutrackers.com/forum/showthread.php?t=123546


hat tip Pathfinder -
VIDEO LINK: Virologist Ab Osterhaus speaks of the mutations and vaccine. "The vaccine will work"

http://www.rnw.nl/english/video/flu-mutations-new-threat
 
Re: Webster Warns Variant of swine influenza specifically attack the lungs with young children "even if the virus mutates, the vaccine and drugs are still effective. "

U.S. experts say children under 10 years of age A stream of the most high-risk
【大纪元12月5日讯】正在香港参加学术会议的国际权威流感专家、美国圣茱德儿童研究医院传染病学系病毒学家韦士伯警告,变种甲型流感(猪流感)病毒已在多个个国家地区出现,专门攻击十岁以下儿童的肺部,导致严重肺炎致死。[/LEFT]

By Reuters December 5 to attend an academic conference at the Hong Kong flu experts, the international authority, the U.S. Children's Research Hospital St. Zhu De, Department of infectious diseases, virologists Weishi Bo warned that variants of influenza (swine flu) virus has been in a number of countries and region, specifically attacks the lungs of children aged under ten, leading to severe pneumonia died.

美国爆疫至今因流感死亡的儿童是往年的7倍,10岁或以下儿童最高危。​

U.S. explosive epidemic of influenza since the death of children due to previous years, seven times, most children under 10 years of age or risk.

他建议香港在疫苗充足的情况下,考虑将免费注射计划涵盖范围由六岁以下扩展至十岁以下。​

He suggested that Hong Kong in the case of vaccine sufficient to consider the scope of the free vaccination program extended by the age of six years or younger.

据 香港媒体报导,刚从美国来港参与学术会议的美国圣茱德儿童研究医院传染病学系病毒学家韦士伯(Robert Webster)表示,美国两个月前开始第二波猪流感,疫情已达高峰并开始回落,整体疫情温和,不过10岁以下儿童病情较严重,美国至今已有800万名儿 童感染猪流感,当中3.6万人需要入院,540人死亡。​

According to Hong Kong media reports, just returned from the United States to participate in academic conferences in the U.S. Children's Research Hospital St. Zhu De, Department of Infectious Diseases virologist Weishi Bo (Robert Webster) said the United States two months ago began a second wave of swine influenza, the epidemic has reached peak and begin to fall, the overall epidemic mild illness for children under 10 years of age, but more serious, the United States so far eight million children infected with swine influenza, of which 36000 people who need hospitalization, 540 people were killed.

?近日发现的变种病毒更能深入患者肺部,非只攻击上呼吸道,尤其是10岁以下儿童患者,能杀死病童!若此变种病毒发展成有效传播,情况更令人忧虑。?韦士伯坦言,至今未知为何变种病毒专攻儿童,但变种病毒杀伤力似乎已增大,目前最担心变种病毒人传人再酿第三波疫潮。​

"Recently, variants of the virus found in the lungs in patients with more in-depth, non-only attack the upper respiratory tract, particularly in children under the age of 10 patients, can kill child! If this variant of the virus to develop into effective communication, the situation is even more worrying." Wei Shibo frankly, is not known yet why the variant virus, specializing in children, but lethal variant of the virus appears to have increased, the current variant of the virus are most worried about another brewing third wave of epidemic human transmission.


他说,70岁或以上长者对甲型流感类似H1病毒已有部份免疫能力,相对感染风险极低,这批长者其实无必要打新型流感针,但绝对需要打季节性流感针。​

He said that senior citizens aged 70 or above is similar to the influenza A H1 viruses have been part of the immunity, the relative risk of infection is very low, these elderly people are in fact no need to fight a new flu shot, but it is absolutely necessary to fight seasonal flu shot.

他建议香港将免费疫苗注射计划应扩大至为10岁以下儿童。​

He suggested that Hong Kong will offer free vaccination program should be extended to children under the age of 10.

香港大学微生物学系荣誉副教授陈国雄表示,猪流感病毒可入侵肠胃,令人腹泻及透过粪便传播,病发两至三日便有病征。​

Department of Microbiology University of Hong Kong Honorary Associate Professor Chan Kwok-hung said that the swine flu virus can invade intestines, cause diarrhea and spread through the feces, the disease will have symptoms two to three days.

小童传播猪流感能力较强,除飞沫外亦可透过粪便传播。​

Child transmission of swine influenza stronger ability, inter alia droplets can also be spread through the feces.

 
Re: Webster Warns Variant of swine influenza specifically attack the lungs with young children "even if the virus mutates, the vaccine and drugs are still effective. "

The port present variety pig epidemic disease studies the child lungs

05/12/2009, Saturday in the morning 11:39



Resize.jsp

Caption: Wei Shibo warned that below ten years old the child infects the pig flu mortality rate, compares seasonal flu high seven times.



[Daily Sun special news]Pig flu spreads the whole world by the unprecedented potential, flu world authority Wei Shibo warned that the variety pig influenza virus already (including Hong Kong) and Norway and so on seven countries appears in inland, attacks below specially ten years old child's lungs, causes the serious pneumonia lethal, suggested that the Hong Kong in the vaccine sufficient situation, considered expands the free injection plan covering scope by six years old below to ten years old below.

The port big medical school suggested that the government changes the treatment strategy, in the epidemic situation initial period, the mix use sensitive luck and the amantadine or the musical sense is clear, retards the sensitive luck to present the antibiotic nature.


Sorrow and the bird flu mix the cards change the super virus
The international flu authority, American Saint zhu Germany Child study Hospital Infectious disease Department virologist Wei Shibo pointed out that Norway first presents two variety pig flu's death case, is called the H222 variety, the virus becomes easier thorough lungs, causes the serious pneumonia. Inland, Japan, Italy, France, the US and Ukraine blue present the variety virus infection case one after another. Although the variety virus has not for the present the widespread person to teach other people, the vaccine and the sensitive luck were still effective, but the American data demonstrated that the child infects the pig flu's mortality rate, compared to seasonal flu high seven times, below ten years old the child should vaccinate early.
Sincerely treat the case regarding the sensitive luck and the musical sense clear invalid child, the US use the new medicine now ?Palami Wei? (Peramivir) the injection, gives the patient the high dose antivirotic medicine by the intravenous injection, the curative effect is good, but before each time uses, needs the American CSC to approve.
Wei Shibo anxious high dissemination's pig flu and the mortality rate reach 50% bird flu virus to mix the cards, turn the high dissemination strength and the high lethality super virus, appealed that various countries do not despise the epidemic situation.
Hong Kong University Medical school Public health Institute assistant professor the beard pointed out auspiciously that the port big research data demonstrated each pig flu patient may give the viral dissemination 1.4 to 1.5 people. The port erupts the speed and the casualty greatly by the mathematical model computation epidemic, the analysis, if retards the sensitive luck to present the antibiotic nature, may use two strategies in epidemic initial period; first, mix use sensitive luck and amantadine; Or uses the musical sense to be clear first, in epidemic only then uses the sensitive luck to the later period. He refers to, the change therapeutic schedule involving different time is infected patient's treatment fairness question, needs the government to consider.
:tiphat:http://66.196.80.202/babelfish/tran...l/news/localNews/Detail.do?type=tsn&id=171574
 
Re: Tamiflu resistance in A/H1N1 flu - historical compilation of news

Re: Tamiflu resistance in A/H1N1 flu - historical compilation of news

Vaccine will still be effective with some genetic changes in virus -



Modeling gene sequences over time in 2009 H1N1 Influenza A Virus populations


Natalia Goni , Alvaro Fajardo , Gonzalo Moratorio , Rodney Colina and Juan Cristina
Virology Journal 2009, 6:215doi:10.1186/1743-422X-6-215
<table cellpadding="0" cellspacing="0"> <tbody> <tr> <td>
</td></tr><tr> <td>Published:</td> <td>4 December 2009</td> </tr> </tbody> </table>Abstract (provisional)

Background

A sudden emergence of Influenza A Virus (IAV) infections with a new pandemic H1N1 IAV is taking place since April of 2009. In order to gain insight into the mode of evolution of these new H1N1 strains, we performed a Bayesian coalescent Markov chain Monte Carlo (MCMC) analysis of full-length neuraminidase (NA) gene sequences of 62 H1N1 IAV strains (isolated from March 30th to by July 28th, 2009) . Results: The results of these studies revealed that the expansion population growth model was the best to fit the sequence data. A mean of evolutionary change of 7.84 x 10-3 nucleotide substitutions per site per year (s/s/y) was obtained for the NA gene. A significant contribution of first codon position to this mean rate was observed.

Maximum clade credibility trees revealed a rapid diversification of NA genes in different genetic lineages, all of them containing Oseltamivir-resistant viruses of very recent emergence.


Mapping of naturally occurring amino acid substitutions in the NA protein from 2009 H1N1 IAV circulating in 62 different patients revealed that substitutions are distributed all around the surface of the molecule, leaving the hydrophobic core and the catalytic site essentially untouched.




Conclusions: High evolutionary rates and fast population growth have contributed to the initial transmission dynamics of 2009 H1N1 IAV. Naturally occurring substitutions are preferentially located at the protein surface and do not interfere with the NA active site. Antigenic regions relevant for vaccine development can differ from previous vaccine strains and vary among patients.


http://www.virologyj.com/content/6/1/215

 
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