tetano
Editor, Senior Moderator
Clin Vaccine Immunol. 2016 Jan 6. pii: CVI.00739-15. [Epub ahead of print]
[h=1]Vitamin supplementation at the time of immunization with cold-adapted influenza virus vaccine corrects poor antibody responses in mice deficient for vitamins A and D.[/h] Surman SL[SUP]1[/SUP], Penkert RR[SUP]1[/SUP], Jones BG[SUP]1[/SUP], Sealy RE[SUP]1[/SUP], Hurwitz JL[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Vitamin A and D deficiencies and insufficiencies are prevalent worldwide in both developed and developing countries. Vitamin metabolites are functionally intertwined in that they are high-affinity ligands for related receptors of the nuclear receptor superfamily. The effects of vitamin A deficiencies (VAD) on antibody responses to respiratory virus vaccines have already been demonstrated. Of particular concern was the reduction in IgA, a first line of defense against pathogens in the respiratory tract. Here are described the individual and combined effects of vitamin A and D deficiencies in mice immunized with an attenuated influenza virus vaccine. Relative to VAD, vitamin D deficiency (VDD) had a limited effect, but double deficiencies for vitamins A and D (VAD+VDD) reduced immune responses in the respiratory tract. The administration of supplemental vitamins A and D to VAD+VDD mice at the time of vaccination restored responses in a dose-dependent manner. Results suggest that vitamin supplementation programs may be beneficial in a clinical setting to promote healthy immune responses toward respiratory virus vaccines in vitamin deficient individuals.
Copyright ? 2016, American Society for Microbiology. All Rights Reserved.
PMID: 26740391 [PubMed - as supplied by publisher]
[h=1]Vitamin supplementation at the time of immunization with cold-adapted influenza virus vaccine corrects poor antibody responses in mice deficient for vitamins A and D.[/h] Surman SL[SUP]1[/SUP], Penkert RR[SUP]1[/SUP], Jones BG[SUP]1[/SUP], Sealy RE[SUP]1[/SUP], Hurwitz JL[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Vitamin A and D deficiencies and insufficiencies are prevalent worldwide in both developed and developing countries. Vitamin metabolites are functionally intertwined in that they are high-affinity ligands for related receptors of the nuclear receptor superfamily. The effects of vitamin A deficiencies (VAD) on antibody responses to respiratory virus vaccines have already been demonstrated. Of particular concern was the reduction in IgA, a first line of defense against pathogens in the respiratory tract. Here are described the individual and combined effects of vitamin A and D deficiencies in mice immunized with an attenuated influenza virus vaccine. Relative to VAD, vitamin D deficiency (VDD) had a limited effect, but double deficiencies for vitamins A and D (VAD+VDD) reduced immune responses in the respiratory tract. The administration of supplemental vitamins A and D to VAD+VDD mice at the time of vaccination restored responses in a dose-dependent manner. Results suggest that vitamin supplementation programs may be beneficial in a clinical setting to promote healthy immune responses toward respiratory virus vaccines in vitamin deficient individuals.
Copyright ? 2016, American Society for Microbiology. All Rights Reserved.
PMID: 26740391 [PubMed - as supplied by publisher]