tetano
Editor, Senior Moderator
Viruses
. 2022 Feb 17;14(2):418.
doi: 10.3390/v14020418.
Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2
Emily Clayton[SUP] 1 [/SUP], Jacob Ackerley[SUP] 1 [/SUP], Marianne Aelmans[SUP] 1 [/SUP], Noor Ali[SUP] 1 [/SUP], Zoe Ashcroft[SUP] 1 [/SUP], Clara Ashton[SUP] 1 [/SUP], Robert Barker[SUP] 1 [/SUP], Vakare Budryte[SUP] 1 [/SUP], Callum Burrows[SUP] 1 [/SUP], Shanshan Cai[SUP] 1 [/SUP], Alex Callaghan[SUP] 1 [/SUP], Jake Carberry[SUP] 1 [/SUP], Rebecca Chatwin[SUP] 1 [/SUP], Isabella Davies[SUP] 1 [/SUP], Chloe Farlow[SUP] 1 [/SUP], Samuel Gamblin[SUP] 1 [/SUP], Aida Iacobut[SUP] 1 [/SUP], Adam Lambe[SUP] 1 [/SUP], Francesca Lynch[SUP] 1 [/SUP], Diana Mihalache[SUP] 1 [/SUP], Amani Mokbel[SUP] 1 [/SUP], Santosh Potamsetty[SUP] 1 [/SUP], Zara Qadir[SUP] 1 [/SUP], Jack Soden[SUP] 1 [/SUP], Xiaohan Sun[SUP] 1 [/SUP], Alexandru Vasile[SUP] 1 [/SUP], Otto Wheeler[SUP] 1 [/SUP], Mohammed A Rohaim[SUP] 1 [/SUP], Muhammad Munir[SUP] 1 [/SUP]
Affiliations
Abstract
The emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the importance of possible animal-to-human (zoonotic) and human-to-animal (zooanthroponotic) transmission and potential spread within animal species. A range of animal species have been verified for SARS-CoV-2 susceptibility, either in vitro or in vivo. However, the molecular bases of such a broad host spectrum for the SARS-CoV-2 remains elusive. Here, we structurally and genetically analysed the interaction between the spike protein, with a particular focus on receptor binding domains (RBDs), of SARS-CoV-2 and its receptor angiotensin-converting enzyme 2 (ACE2) for all conceivably susceptible groups of animals to gauge the structural bases of the SARS-CoV-2 host spectrum. We describe our findings in the context of existing animal infection-based models to provide a foundation on the possible virus persistence in animals and their implications in the future eradication of COVID-19.
Keywords: ACE2; SARS-CoV-2; eradication; transmission; zoonotic.
. 2022 Feb 17;14(2):418.
doi: 10.3390/v14020418.
Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2
Emily Clayton[SUP] 1 [/SUP], Jacob Ackerley[SUP] 1 [/SUP], Marianne Aelmans[SUP] 1 [/SUP], Noor Ali[SUP] 1 [/SUP], Zoe Ashcroft[SUP] 1 [/SUP], Clara Ashton[SUP] 1 [/SUP], Robert Barker[SUP] 1 [/SUP], Vakare Budryte[SUP] 1 [/SUP], Callum Burrows[SUP] 1 [/SUP], Shanshan Cai[SUP] 1 [/SUP], Alex Callaghan[SUP] 1 [/SUP], Jake Carberry[SUP] 1 [/SUP], Rebecca Chatwin[SUP] 1 [/SUP], Isabella Davies[SUP] 1 [/SUP], Chloe Farlow[SUP] 1 [/SUP], Samuel Gamblin[SUP] 1 [/SUP], Aida Iacobut[SUP] 1 [/SUP], Adam Lambe[SUP] 1 [/SUP], Francesca Lynch[SUP] 1 [/SUP], Diana Mihalache[SUP] 1 [/SUP], Amani Mokbel[SUP] 1 [/SUP], Santosh Potamsetty[SUP] 1 [/SUP], Zara Qadir[SUP] 1 [/SUP], Jack Soden[SUP] 1 [/SUP], Xiaohan Sun[SUP] 1 [/SUP], Alexandru Vasile[SUP] 1 [/SUP], Otto Wheeler[SUP] 1 [/SUP], Mohammed A Rohaim[SUP] 1 [/SUP], Muhammad Munir[SUP] 1 [/SUP]
Affiliations
- PMID: 35216011
- DOI: 10.3390/v14020418
Abstract
The emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the importance of possible animal-to-human (zoonotic) and human-to-animal (zooanthroponotic) transmission and potential spread within animal species. A range of animal species have been verified for SARS-CoV-2 susceptibility, either in vitro or in vivo. However, the molecular bases of such a broad host spectrum for the SARS-CoV-2 remains elusive. Here, we structurally and genetically analysed the interaction between the spike protein, with a particular focus on receptor binding domains (RBDs), of SARS-CoV-2 and its receptor angiotensin-converting enzyme 2 (ACE2) for all conceivably susceptible groups of animals to gauge the structural bases of the SARS-CoV-2 host spectrum. We describe our findings in the context of existing animal infection-based models to provide a foundation on the possible virus persistence in animals and their implications in the future eradication of COVID-19.
Keywords: ACE2; SARS-CoV-2; eradication; transmission; zoonotic.