tetano
Editor, Senior Moderator
Viruses
. 2021 May 24;13(6):971.
doi: 10.3390/v13060971.
Selecting and Using the Appropriate Influenza Vaccine for Each Individual
Toshiki Sekiya[SUP] 1 2 3 [/SUP], Marumi Ohno[SUP] 1 [/SUP], Naoki Nomura[SUP] 1 [/SUP], Chimuka Handabile[SUP] 1 [/SUP], Masashi Shingai[SUP] 1 2 [/SUP], David C Jackson[SUP] 2 3 [/SUP], Lorena E Brown[SUP] 2 3 [/SUP], Hiroshi Kida[SUP] 1 2 4 [/SUP]
Affiliations
Abstract
Despite seasonal influenza vaccines having been routinely used for many decades, influenza A virus continues to pose a global threat to humans, causing high morbidity and mortality each year. The effectiveness of the vaccine is largely dependent on how well matched the vaccine strains are with the circulating influenza virus strains. Furthermore, low vaccine efficacy in naïve populations such as young children, or in the elderly, who possess weakened immune systems, indicates that influenza vaccines need to be more personalized to provide broader community protection. Advances in both vaccine technologies and our understanding of influenza virus infection and immunity have led to the design of a variety of alternate vaccine strategies to extend population protection against influenza, some of which are now in use. In this review, we summarize the progress in the field of influenza vaccines, including the advantages and disadvantages of different strategies, and discuss future prospects. We also highlight some of the challenges to be faced in the ongoing effort to control influenza through vaccination.
Keywords: pandemic preparedness; priming immune response; seasonal influenza vaccine; whole virus particle vaccine.
. 2021 May 24;13(6):971.
doi: 10.3390/v13060971.
Selecting and Using the Appropriate Influenza Vaccine for Each Individual
Toshiki Sekiya[SUP] 1 2 3 [/SUP], Marumi Ohno[SUP] 1 [/SUP], Naoki Nomura[SUP] 1 [/SUP], Chimuka Handabile[SUP] 1 [/SUP], Masashi Shingai[SUP] 1 2 [/SUP], David C Jackson[SUP] 2 3 [/SUP], Lorena E Brown[SUP] 2 3 [/SUP], Hiroshi Kida[SUP] 1 2 4 [/SUP]
Affiliations
- PMID: 34073843
- DOI: 10.3390/v13060971
Abstract
Despite seasonal influenza vaccines having been routinely used for many decades, influenza A virus continues to pose a global threat to humans, causing high morbidity and mortality each year. The effectiveness of the vaccine is largely dependent on how well matched the vaccine strains are with the circulating influenza virus strains. Furthermore, low vaccine efficacy in naïve populations such as young children, or in the elderly, who possess weakened immune systems, indicates that influenza vaccines need to be more personalized to provide broader community protection. Advances in both vaccine technologies and our understanding of influenza virus infection and immunity have led to the design of a variety of alternate vaccine strategies to extend population protection against influenza, some of which are now in use. In this review, we summarize the progress in the field of influenza vaccines, including the advantages and disadvantages of different strategies, and discuss future prospects. We also highlight some of the challenges to be faced in the ongoing effort to control influenza through vaccination.
Keywords: pandemic preparedness; priming immune response; seasonal influenza vaccine; whole virus particle vaccine.