tetano
Editor, Senior Moderator
Viruses
. 2020 Dec 6;12(12):E1401.
doi: 10.3390/v12121401.
Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix
G?bor Kemenesi[SUP] 1 2 [/SUP], Safia Zeghbib[SUP] 1 2 [/SUP], Bal?zs A Somogyi[SUP] 1 2 [/SUP], G?bor Endre T?th[SUP] 1 2 [/SUP], Kriszti?n B?nyai[SUP] 3 [/SUP], Norbert Solymosi[SUP] 4 [/SUP], Peter M Szabo[SUP] 5 [/SUP], Istv?n Szab?[SUP] 6 [/SUP], ?d?m B?lint[SUP] 6 [/SUP], P?ter Urb?n[SUP] 7 [/SUP], R?bert Herczeg[SUP] 7 [/SUP], Attila Gyenesei[SUP] 7 8 [/SUP], ?gnes Nagy[SUP] 9 [/SUP], Csaba Istv?n Pereszl?nyi[SUP] 9 [/SUP], Gergely Csaba Babinszky[SUP] 9 [/SUP], G?bor Dud?s[SUP] 9 [/SUP], Gabriella Terhes[SUP] 10 [/SUP], Viktor Z?ldi[SUP] 11 [/SUP], R?bert Lovas[SUP] 12 [/SUP], Szabolcs Tenczer[SUP] 12 [/SUP], L?szl? Kornya[SUP] 13 [/SUP], Ferenc Jakab[SUP] 1 2 [/SUP]
Affiliations
Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 is the third highly pathogenic human coronavirus in history. Since the emergence in Hubei province, China, during late 2019, the situation evolved to pandemic level. Following China, Europe was the second epicenter of the pandemic. To better comprehend the detailed founder mechanisms of the epidemic evolution in Central-Eastern Europe, particularly in Hungary, we determined the full-length SARS-CoV-2 genomes from 32 clinical samples collected from laboratory confirmed COVID-19 patients over the first month of disease in Hungary. We applied a haplotype network analysis on all available complete genomic sequences of SARS-CoV-2 from GISAID database as of 21 April 2020. We performed additional phylogenetic and phylogeographic analyses to achieve the recognition of multiple and parallel introductory events into our region. Here, we present a publicly available network imaging of the worldwide haplotype relations of SARS-CoV-2 sequences and conclude the founder mechanisms of the outbreak in Central-Eastern Europe.
Keywords: SARS-CoV-2; human coronavirus; network analysis; outbreak; pandemic; phylodynamics.
. 2020 Dec 6;12(12):E1401.
doi: 10.3390/v12121401.
Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix
G?bor Kemenesi[SUP] 1 2 [/SUP], Safia Zeghbib[SUP] 1 2 [/SUP], Bal?zs A Somogyi[SUP] 1 2 [/SUP], G?bor Endre T?th[SUP] 1 2 [/SUP], Kriszti?n B?nyai[SUP] 3 [/SUP], Norbert Solymosi[SUP] 4 [/SUP], Peter M Szabo[SUP] 5 [/SUP], Istv?n Szab?[SUP] 6 [/SUP], ?d?m B?lint[SUP] 6 [/SUP], P?ter Urb?n[SUP] 7 [/SUP], R?bert Herczeg[SUP] 7 [/SUP], Attila Gyenesei[SUP] 7 8 [/SUP], ?gnes Nagy[SUP] 9 [/SUP], Csaba Istv?n Pereszl?nyi[SUP] 9 [/SUP], Gergely Csaba Babinszky[SUP] 9 [/SUP], G?bor Dud?s[SUP] 9 [/SUP], Gabriella Terhes[SUP] 10 [/SUP], Viktor Z?ldi[SUP] 11 [/SUP], R?bert Lovas[SUP] 12 [/SUP], Szabolcs Tenczer[SUP] 12 [/SUP], L?szl? Kornya[SUP] 13 [/SUP], Ferenc Jakab[SUP] 1 2 [/SUP]
Affiliations
- PMID: 33291299
- DOI: 10.3390/v12121401
Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 is the third highly pathogenic human coronavirus in history. Since the emergence in Hubei province, China, during late 2019, the situation evolved to pandemic level. Following China, Europe was the second epicenter of the pandemic. To better comprehend the detailed founder mechanisms of the epidemic evolution in Central-Eastern Europe, particularly in Hungary, we determined the full-length SARS-CoV-2 genomes from 32 clinical samples collected from laboratory confirmed COVID-19 patients over the first month of disease in Hungary. We applied a haplotype network analysis on all available complete genomic sequences of SARS-CoV-2 from GISAID database as of 21 April 2020. We performed additional phylogenetic and phylogeographic analyses to achieve the recognition of multiple and parallel introductory events into our region. Here, we present a publicly available network imaging of the worldwide haplotype relations of SARS-CoV-2 sequences and conclude the founder mechanisms of the outbreak in Central-Eastern Europe.
Keywords: SARS-CoV-2; human coronavirus; network analysis; outbreak; pandemic; phylodynamics.