tetano
Editor, Senior Moderator
Viruses
. 2020 Dec 30;13(1):E45.
doi: 10.3390/v13010045.
Markers Associated with COVID-19 Susceptibility, Resistance, and Severity
Aisha D Fakhroo[SUP] 1 [/SUP], Asmaa A Al Thani[SUP] 2 [/SUP], Hadi M Yassine[SUP] 2 [/SUP]
Affiliations
Abstract
In December 2019, the latest member of the coronavirus family, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in Wuhan, China, leading to the outbreak of an unusual viral pneumonia known as coronavirus disease 2019 (COVID-19). COVID-19 was then declared as a pandemic in March 2020 by the World Health Organization (WHO). The initial mortality rate of COVID-19 declared by WHO was 2%; however, this rate has increased to 3.4% as of 3 March 2020. People of all ages can be infected with SARS-CoV-2, but those aged 60 or above and those with underlying medical conditions are more prone to develop severe symptoms that may lead to death. Patients with severe infection usually experience a hyper pro-inflammatory immune reaction (i.e., cytokine storm) causing acute respiratory distress syndrome (ARDS), which has been shown to be the leading cause of death in COVID-19 patients. However, the factors associated with COVID-19 susceptibility, resistance and severity remain poorly understood. In this review, we thoroughly explore the correlation between various host, viral and environmental markers, and SARS-CoV-2 in terms of susceptibility and severity.
Keywords: COVID-19; SARS; pathogenesis; resistance; susceptibility.
. 2020 Dec 30;13(1):E45.
doi: 10.3390/v13010045.
Markers Associated with COVID-19 Susceptibility, Resistance, and Severity
Aisha D Fakhroo[SUP] 1 [/SUP], Asmaa A Al Thani[SUP] 2 [/SUP], Hadi M Yassine[SUP] 2 [/SUP]
Affiliations
- PMID: 33396584
- DOI: 10.3390/v13010045
Abstract
In December 2019, the latest member of the coronavirus family, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in Wuhan, China, leading to the outbreak of an unusual viral pneumonia known as coronavirus disease 2019 (COVID-19). COVID-19 was then declared as a pandemic in March 2020 by the World Health Organization (WHO). The initial mortality rate of COVID-19 declared by WHO was 2%; however, this rate has increased to 3.4% as of 3 March 2020. People of all ages can be infected with SARS-CoV-2, but those aged 60 or above and those with underlying medical conditions are more prone to develop severe symptoms that may lead to death. Patients with severe infection usually experience a hyper pro-inflammatory immune reaction (i.e., cytokine storm) causing acute respiratory distress syndrome (ARDS), which has been shown to be the leading cause of death in COVID-19 patients. However, the factors associated with COVID-19 susceptibility, resistance and severity remain poorly understood. In this review, we thoroughly explore the correlation between various host, viral and environmental markers, and SARS-CoV-2 in terms of susceptibility and severity.
Keywords: COVID-19; SARS; pathogenesis; resistance; susceptibility.