tetano
Editor, Senior Moderator
Viruses. 2020 May 3;12(5). pii: E504. doi: 10.3390/v12050504.
Host Protective Immune Responses against Influenza A Virus Infection.
Jung HE[SUP]1[/SUP], Lee HK[SUP]1,[/SUP][SUP]2[/SUP].
Author information
Abstract
Influenza viruses cause infectious respiratory disease characterized by fever, myalgia, and congestion, ranging in severity from mild to life-threating. Although enormous efforts have aimed to prevent and treat influenza infections, seasonal and pandemic influenza outbreaks remain a major public health concern. This is largely because influenza viruses rapidly undergo genetic mutations that restrict the long-lasting efficacy of vaccine-induced immune responses and therapeutic regimens. In this review, we discuss the virological features of influenza A viruses and provide an overview of current knowledge of the innate sensing of invading influenza viruses and the protective immune responses in the host.
KEYWORDS:
anti-influenza immune responses; influenza virus
PMID:32375274DOI:10.3390/v12050504
Free full text
Host Protective Immune Responses against Influenza A Virus Infection.
Jung HE[SUP]1[/SUP], Lee HK[SUP]1,[/SUP][SUP]2[/SUP].
Author information
Abstract
Influenza viruses cause infectious respiratory disease characterized by fever, myalgia, and congestion, ranging in severity from mild to life-threating. Although enormous efforts have aimed to prevent and treat influenza infections, seasonal and pandemic influenza outbreaks remain a major public health concern. This is largely because influenza viruses rapidly undergo genetic mutations that restrict the long-lasting efficacy of vaccine-induced immune responses and therapeutic regimens. In this review, we discuss the virological features of influenza A viruses and provide an overview of current knowledge of the innate sensing of invading influenza viruses and the protective immune responses in the host.
KEYWORDS:
anti-influenza immune responses; influenza virus
PMID:32375274DOI:10.3390/v12050504
Free full text