tetano
Editor, Senior Moderator
Viruses
. 2024 Feb 24;16(3):353.
doi: 10.3390/v16030353. Cross-Species Transmission Potential of H4 Avian Influenza Viruses in China: Epidemiological and Evolutionary Study
Shuxia Lin[SUP] 1 2 3 [/SUP], Ye Zhang[SUP] 3 [/SUP], Jiaying Yang[SUP] 1 2 3 [/SUP], Lei Yang[SUP] 3 [/SUP], Xiyan Li[SUP] 3 [/SUP], Hong Bo[SUP] 3 [/SUP], Jia Liu[SUP] 3 [/SUP], Min Tan[SUP] 3 [/SUP], Wenfei Zhu[SUP] 3 [/SUP], Dayan Wang[SUP] 3 [/SUP], Yuelong Shu[SUP] 1 2 4 [/SUP]
Affiliations
H4 avian influenza viruses (AIVs) have been widely detected in live poultry markets in China. However, the potential public health impact of H4 AIVs remains largely uncertain. Here, we fully analyzed the distribution and phylogenetic relationship of H4 AIVs in China. We obtained 31 isolates of H4 viruses in China during 2009-2022 through surveillance in poultry-associated environments, such as live poultry markets and poultry farms. Genomic sequence analysis together with publicly available data revealed that frequent reassortment and introduction of H4 AIV from wild birds to poultry may have occurred. We identified 62 genotypes among 127 whole genome sequences of H4 viruses in China, indicating that H4 AIVs had great genetic diversity in China. We also investigated molecular markers and found that drug resistance mutations frequently occurred in the M2 protein and a few mutations related to receptor binding and the host signature in H4 AIVs. Our study demonstrates the cross-species transmission potential of H4 AIVs in China and provides some reference significance for its risk assessment.
Keywords: H4; avian influenza virus; cross-species transmission; epidemiological; evolutionary; potential threat.
. 2024 Feb 24;16(3):353.
doi: 10.3390/v16030353. Cross-Species Transmission Potential of H4 Avian Influenza Viruses in China: Epidemiological and Evolutionary Study
Shuxia Lin[SUP] 1 2 3 [/SUP], Ye Zhang[SUP] 3 [/SUP], Jiaying Yang[SUP] 1 2 3 [/SUP], Lei Yang[SUP] 3 [/SUP], Xiyan Li[SUP] 3 [/SUP], Hong Bo[SUP] 3 [/SUP], Jia Liu[SUP] 3 [/SUP], Min Tan[SUP] 3 [/SUP], Wenfei Zhu[SUP] 3 [/SUP], Dayan Wang[SUP] 3 [/SUP], Yuelong Shu[SUP] 1 2 4 [/SUP]
Affiliations
- PMID: 38543719
- PMCID: PMC10974465
- DOI: 10.3390/v16030353
H4 avian influenza viruses (AIVs) have been widely detected in live poultry markets in China. However, the potential public health impact of H4 AIVs remains largely uncertain. Here, we fully analyzed the distribution and phylogenetic relationship of H4 AIVs in China. We obtained 31 isolates of H4 viruses in China during 2009-2022 through surveillance in poultry-associated environments, such as live poultry markets and poultry farms. Genomic sequence analysis together with publicly available data revealed that frequent reassortment and introduction of H4 AIV from wild birds to poultry may have occurred. We identified 62 genotypes among 127 whole genome sequences of H4 viruses in China, indicating that H4 AIVs had great genetic diversity in China. We also investigated molecular markers and found that drug resistance mutations frequently occurred in the M2 protein and a few mutations related to receptor binding and the host signature in H4 AIVs. Our study demonstrates the cross-species transmission potential of H4 AIVs in China and provides some reference significance for its risk assessment.
Keywords: H4; avian influenza virus; cross-species transmission; epidemiological; evolutionary; potential threat.