tetano
Editor, Senior Moderator
Viruses
. 2022 Mar 30;14(4):728.
doi: 10.3390/v14040728.
Characterization of H9N2 Avian Influenza Viruses Isolated from Poultry Products in a Mouse Model
Jurika Murakami[SUP] 1 [/SUP], Akihiro Shibata[SUP] 2 [/SUP], Gabriele Neumann[SUP] 3 [/SUP], Masaki Imai[SUP] 1 4 [/SUP], Tokiko Watanabe[SUP] 1 5 6 [/SUP], Yoshihiro Kawaoka[SUP] 1 3 4 [/SUP]
Affiliations
Abstract
Low pathogenic H9N2 avian influenza viruses have spread in wild birds and poultry worldwide. Recently, the number of human cases of H9N2 virus infection has increased in China and other countries, heightening pandemic concerns. In Japan, H9N2 viruses are not yet enzootic; however, avian influenza viruses, including H5N1, H7N9, H5N6, and H9N2, have been repeatedly detected in raw poultry meat carried by international flight passengers from Asian countries to Japan. Although H9N2 virus-contaminated poultry products intercepted by the animal quarantine service at the Japan border have been characterized in chickens and ducks, the biological properties of those H9N2 viruses in mammals remain unclear. Here, we characterized the biological features of two H9N2 virus isolates [A/chicken/Japan/AQ-HE28-50/2016 (Ck/HE28-50) and A/chicken/Japan/AQ-HE28-57/2016 (Ck/HE28-57)] in a mouse model. We found that these H9N2 viruses replicate well in the respiratory tract of infected mice without adaptation, and that Ck/HE28-57 caused body weight loss in the infected mice. Our results indicate that H9N2 avian influenza viruses isolated from raw chicken meat products illegally brought to Japan can potentially infect and cause disease in mammals.
Keywords: H9N2; avian influenza viruses; pathogenicity and replicative ability in mammals.
. 2022 Mar 30;14(4):728.
doi: 10.3390/v14040728.
Characterization of H9N2 Avian Influenza Viruses Isolated from Poultry Products in a Mouse Model
Jurika Murakami[SUP] 1 [/SUP], Akihiro Shibata[SUP] 2 [/SUP], Gabriele Neumann[SUP] 3 [/SUP], Masaki Imai[SUP] 1 4 [/SUP], Tokiko Watanabe[SUP] 1 5 6 [/SUP], Yoshihiro Kawaoka[SUP] 1 3 4 [/SUP]
Affiliations
- PMID: 35458458
- PMCID: PMC9032349
- DOI: 10.3390/v14040728
Abstract
Low pathogenic H9N2 avian influenza viruses have spread in wild birds and poultry worldwide. Recently, the number of human cases of H9N2 virus infection has increased in China and other countries, heightening pandemic concerns. In Japan, H9N2 viruses are not yet enzootic; however, avian influenza viruses, including H5N1, H7N9, H5N6, and H9N2, have been repeatedly detected in raw poultry meat carried by international flight passengers from Asian countries to Japan. Although H9N2 virus-contaminated poultry products intercepted by the animal quarantine service at the Japan border have been characterized in chickens and ducks, the biological properties of those H9N2 viruses in mammals remain unclear. Here, we characterized the biological features of two H9N2 virus isolates [A/chicken/Japan/AQ-HE28-50/2016 (Ck/HE28-50) and A/chicken/Japan/AQ-HE28-57/2016 (Ck/HE28-57)] in a mouse model. We found that these H9N2 viruses replicate well in the respiratory tract of infected mice without adaptation, and that Ck/HE28-57 caused body weight loss in the infected mice. Our results indicate that H9N2 avian influenza viruses isolated from raw chicken meat products illegally brought to Japan can potentially infect and cause disease in mammals.
Keywords: H9N2; avian influenza viruses; pathogenicity and replicative ability in mammals.