tetano
Editor, Senior Moderator
Viruses
. 2021 Jun 13;13(6):1137.
doi: 10.3390/v13061137.
Changes in Cell-Mediated Immunity (IFN-γ and Granzyme B) Following Influenza Vaccination
Naruhito Otani[SUP] 1 [/SUP], Kazuhiko Nakajima[SUP] 2 [/SUP], Kaori Ishikawa[SUP] 2 [/SUP], Kaoru Ichiki[SUP] 2 [/SUP], Takashi Ueda[SUP] 2 [/SUP], Yoshio Takesue[SUP] 2 [/SUP], Takuma Yamamoto[SUP] 3 [/SUP], Susumu Tanimura[SUP] 4 [/SUP], Masayuki Shima[SUP] 1 [/SUP], Toshiomi Okuno[SUP] 5 [/SUP]
Affiliations
Abstract
Interferon gamma (IFN-γ) is considered a key moderator of cell-mediated immunity. However, little is known about its association with granzyme B, which plays an important role in the effector function of cytotoxic T lymphocytes (CTLs). In the present study, we collected blood samples from 32 healthy adults before and after vaccination with inactivated influenza vaccine in 2017/18 to measure the levels of IFN-γ and granzyme B, which play roles in cell-mediated immunity, and hemagglutination inhibition (HAI) antibody, which plays a role in humoral immunity. The levels of IFN-γ and granzyme B were significantly correlated both before and after vaccination. Furthermore, the post-vaccine fold increases in the IFN-γ and granzyme B levels were significantly correlated. The levels of IFN-γ and granzyme B decreased five months after vaccination in more than half of the subjects who exhibited an increase in IFN-γ and granzyme B at two weeks post-vaccination. This is the first study to investigate the correlation between IFN-γ and granzyme B levels following influenza vaccination. Our study suggests that both IFN-γ and granzyme B can be used as markers of cell-mediated immunity.
Keywords: IFN-γ; cell-mediated immunity; granzyme B; influenza; vaccine.
. 2021 Jun 13;13(6):1137.
doi: 10.3390/v13061137.
Changes in Cell-Mediated Immunity (IFN-γ and Granzyme B) Following Influenza Vaccination
Naruhito Otani[SUP] 1 [/SUP], Kazuhiko Nakajima[SUP] 2 [/SUP], Kaori Ishikawa[SUP] 2 [/SUP], Kaoru Ichiki[SUP] 2 [/SUP], Takashi Ueda[SUP] 2 [/SUP], Yoshio Takesue[SUP] 2 [/SUP], Takuma Yamamoto[SUP] 3 [/SUP], Susumu Tanimura[SUP] 4 [/SUP], Masayuki Shima[SUP] 1 [/SUP], Toshiomi Okuno[SUP] 5 [/SUP]
Affiliations
- PMID: 34199161
- DOI: 10.3390/v13061137
Abstract
Interferon gamma (IFN-γ) is considered a key moderator of cell-mediated immunity. However, little is known about its association with granzyme B, which plays an important role in the effector function of cytotoxic T lymphocytes (CTLs). In the present study, we collected blood samples from 32 healthy adults before and after vaccination with inactivated influenza vaccine in 2017/18 to measure the levels of IFN-γ and granzyme B, which play roles in cell-mediated immunity, and hemagglutination inhibition (HAI) antibody, which plays a role in humoral immunity. The levels of IFN-γ and granzyme B were significantly correlated both before and after vaccination. Furthermore, the post-vaccine fold increases in the IFN-γ and granzyme B levels were significantly correlated. The levels of IFN-γ and granzyme B decreased five months after vaccination in more than half of the subjects who exhibited an increase in IFN-γ and granzyme B at two weeks post-vaccination. This is the first study to investigate the correlation between IFN-γ and granzyme B levels following influenza vaccination. Our study suggests that both IFN-γ and granzyme B can be used as markers of cell-mediated immunity.
Keywords: IFN-γ; cell-mediated immunity; granzyme B; influenza; vaccine.