tetano
Editor, Senior Moderator
Viruses
. 2021 Apr 21;13(5):724.
doi: 10.3390/v13050724.
A Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B.1.1.33 Circulating in Brazil
Paola Cristina Resende[SUP] 1 2 [/SUP], Tiago Gr?f[SUP] 1 3 [/SUP], Anna Carolina Dias Paix?o[SUP] 1 2 [/SUP], Luciana Appolinario[SUP] 1 2 [/SUP], Renata Serrano Lopes[SUP] 1 2 [/SUP], Ana Carolina da Fonseca Mendon?a[SUP] 1 2 [/SUP], Alice Sampaio Barreto da Rocha[SUP] 1 2 [/SUP], Fernando Couto Motta[SUP] 1 2 [/SUP], Lidio Gon?alves Lima Neto[SUP] 4 [/SUP], Ricardo Khouri[SUP] 1 3 5 [/SUP], Camila I de Oliveira[SUP] 1 3 5 [/SUP], Pedro Santos-Muccillo[SUP] 1 3 6 [/SUP], Jo?o Felipe Bezerra[SUP] 7 [/SUP], Dalane Loudal Florentino Teixeira[SUP] 8 [/SUP], Irina Riediger[SUP] 9 [/SUP], Maria do Carmo Debur[SUP] 9 [/SUP], Rodrigo Ribeiro-Rodrigues[SUP] 10 11 [/SUP], Anderson Brandao Leite[SUP] 12 [/SUP], Cliomar Alves do Santos[SUP] 13 [/SUP], Tatiana Sch?ffer Gregianini[SUP] 14 [/SUP], Sandra Bianchini Fernandes[SUP] 15 [/SUP], Andr? Felipe Leal Bernardes[SUP] 16 [/SUP], Andrea Cony Cavalcanti[SUP] 17 [/SUP], F?bio Miyajima[SUP] 1 18 [/SUP], Claudio Sachhi[SUP] 19 [/SUP], Tirza Mattos[SUP] 20 [/SUP], Cristiano Fernandes da Costa[SUP] 21 [/SUP], Edson Delatorre[SUP] 1 22 [/SUP], Gabriel L Wallau[SUP] 1 23 [/SUP], Felipe G Naveca[SUP] 1 24 [/SUP], Gonzalo Bello[SUP] 1 25 [/SUP], Marilda Mendon?a Siqueira[SUP] 1 2 [/SUP]
Affiliations
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Brazil was dominated by two lineages designated as B.1.1.28 and B.1.1.33. The two SARS-CoV-2 variants harboring mutations at the receptor-binding domain of the Spike (S) protein, designated as lineages P.1 and P.2, evolved from lineage B.1.1.28 and are rapidly spreading in Brazil. Lineage P.1 is considered a Variant of Concern (VOC) because of the presence of multiple mutations in the S protein (including K417T, E484K, N501Y), while lineage P.2 only harbors mutation S:E484K and is considered a Variant of Interest (VOI). On the other hand, epidemiologically relevant B.1.1.33 deriving lineages have not been described so far. Here we report the identification of a new SARS-CoV-2 VOI within lineage B.1.1.33 that also harbors mutation S:E484K and was detected in Brazil between November 2020 and February 2021. This VOI displayed four non-synonymous lineage-defining mutations (NSP3:A1711V, NSP6:F36L, S:E484K, and NS7b:E33A) and was designated as lineage N.9. The VOI N.9 probably emerged in August 2020 and has spread across different Brazilian states from the Southeast, South, North, and Northeast regions.
Keywords: Brazil; E484K; SARS-CoV-2; genomic epidemiology; variant of Interest.
. 2021 Apr 21;13(5):724.
doi: 10.3390/v13050724.
A Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B.1.1.33 Circulating in Brazil
Paola Cristina Resende[SUP] 1 2 [/SUP], Tiago Gr?f[SUP] 1 3 [/SUP], Anna Carolina Dias Paix?o[SUP] 1 2 [/SUP], Luciana Appolinario[SUP] 1 2 [/SUP], Renata Serrano Lopes[SUP] 1 2 [/SUP], Ana Carolina da Fonseca Mendon?a[SUP] 1 2 [/SUP], Alice Sampaio Barreto da Rocha[SUP] 1 2 [/SUP], Fernando Couto Motta[SUP] 1 2 [/SUP], Lidio Gon?alves Lima Neto[SUP] 4 [/SUP], Ricardo Khouri[SUP] 1 3 5 [/SUP], Camila I de Oliveira[SUP] 1 3 5 [/SUP], Pedro Santos-Muccillo[SUP] 1 3 6 [/SUP], Jo?o Felipe Bezerra[SUP] 7 [/SUP], Dalane Loudal Florentino Teixeira[SUP] 8 [/SUP], Irina Riediger[SUP] 9 [/SUP], Maria do Carmo Debur[SUP] 9 [/SUP], Rodrigo Ribeiro-Rodrigues[SUP] 10 11 [/SUP], Anderson Brandao Leite[SUP] 12 [/SUP], Cliomar Alves do Santos[SUP] 13 [/SUP], Tatiana Sch?ffer Gregianini[SUP] 14 [/SUP], Sandra Bianchini Fernandes[SUP] 15 [/SUP], Andr? Felipe Leal Bernardes[SUP] 16 [/SUP], Andrea Cony Cavalcanti[SUP] 17 [/SUP], F?bio Miyajima[SUP] 1 18 [/SUP], Claudio Sachhi[SUP] 19 [/SUP], Tirza Mattos[SUP] 20 [/SUP], Cristiano Fernandes da Costa[SUP] 21 [/SUP], Edson Delatorre[SUP] 1 22 [/SUP], Gabriel L Wallau[SUP] 1 23 [/SUP], Felipe G Naveca[SUP] 1 24 [/SUP], Gonzalo Bello[SUP] 1 25 [/SUP], Marilda Mendon?a Siqueira[SUP] 1 2 [/SUP]
Affiliations
- PMID: 33919314
- DOI: 10.3390/v13050724
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Brazil was dominated by two lineages designated as B.1.1.28 and B.1.1.33. The two SARS-CoV-2 variants harboring mutations at the receptor-binding domain of the Spike (S) protein, designated as lineages P.1 and P.2, evolved from lineage B.1.1.28 and are rapidly spreading in Brazil. Lineage P.1 is considered a Variant of Concern (VOC) because of the presence of multiple mutations in the S protein (including K417T, E484K, N501Y), while lineage P.2 only harbors mutation S:E484K and is considered a Variant of Interest (VOI). On the other hand, epidemiologically relevant B.1.1.33 deriving lineages have not been described so far. Here we report the identification of a new SARS-CoV-2 VOI within lineage B.1.1.33 that also harbors mutation S:E484K and was detected in Brazil between November 2020 and February 2021. This VOI displayed four non-synonymous lineage-defining mutations (NSP3:A1711V, NSP6:F36L, S:E484K, and NS7b:E33A) and was designated as lineage N.9. The VOI N.9 probably emerged in August 2020 and has spread across different Brazilian states from the Southeast, South, North, and Northeast regions.
Keywords: Brazil; E484K; SARS-CoV-2; genomic epidemiology; variant of Interest.